1.21.4.3: sarcosine reductase
This is an abbreviated version!
For detailed information about sarcosine reductase, go to the full flat file.
Reaction
ECTree
Advanced search results
Reaction
Reaction on EC 1.21.4.3 - sarcosine reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
acetyl phosphate + methylamine + thioredoxin disulfide + H2O = N-methylglycine + phosphate + thioredoxin
The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.4 (betaine reductase)
-
-
-