1.21.4.1: D-proline reductase

This is an abbreviated version!
For detailed information about D-proline reductase, go to the full flat file.

Reaction

Synonyms

5-aminopentanoate:lipoate oxidoreductase (cyclizing), D-proline reductase, D-proline reductase (dithiol), EC 1.4.1.6, EC 1.4.4.1, lipoate-linked proline reductase, PrdB

ECTree

     1 Oxidoreductases

         1.21 Catalysing the reaction X-H + Y-H = X-Y

             1.21.4 With a disulfide as acceptor

                1.21.4.1 D-proline reductase

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Results	in table
5	Activating Compound
684	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Cofactor
2	Expression
3	General Information
2	General Stability
23	Inhibitors
6	Localization
12	Metals/Ions
11	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
16	Organism
6	Pathway
1	pH Optimum
1	pH Stability
10	Purification (Commentary)
1	Reaction
5	Reaction Type
16	Reference
6	Specific Activity [micromol/min/mg]
3	Storage Stability
28	Substrates and Products (Substrate)
8	Subunits
9	Synonyms
1	Systematic Name

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 1.21.4.1 - D-proline reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-allohydroxyproline + dihydrolipoate

5-amino-4-hydroxypentanoic acid + lipoate

Acetoanaerobium sticklandii

-

barely detectable activity

2121

-

-

ir

D-proline + 1,3-dimercaptopropanol

5-aminopentanoic acid + ?

2 entries

D-proline + 6,8-dimercaptooctanoate

5-aminopentanoic acid + ?

Acetoanaerobium sticklandii

-

-

2121

-

-

ir

D-proline + beta-mercaptoethanol

?

Acetoanaerobium sticklandii

-

-

2121

-

-

ir

D-proline + dihydrolipoate

delta-aminovaleric acid + lipoate

2 entries

D-proline + dithiol (reduced)

5-aminopentanoic acid + oxidized dithiol

5 entries

D-proline + dithiothreitol

5-amino pentanoic acid + ?

7 entries

D-proline + DL-lipoic acid

5-aminopentanoic acid + ?

Acetoanaerobium sticklandii

-

-

2121

-

-

ir

D-proline + NADH

5-aminopentanoic acid + NAD+

4 entries

D-proline + NADH + H+

5-aminovalerate + NAD+

Acetoanaerobium sticklandii

-

-

704292

-

-

r

D-proline + 1,3-dimercaptopropanol

5-aminopentanoic acid + ?

Acetoanaerobium sticklandii

-

-

2121

-

-

ir

D-proline + 1,3-dimercaptopropanol

5-aminopentanoic acid + ?

Acetoanaerobium sticklandii

-

oxidation of 1,3-dimercaptopropanol cannot be replaced by molecular hydrogen, NADH+ or a number of other reducing agents

2121

-

-

ir

D-proline + dihydrolipoate

delta-aminovaleric acid + lipoate

Acetoanaerobium sticklandii

-

-

2121

-

-

ir

D-proline + dihydrolipoate

delta-aminovaleric acid + lipoate

Clostridium sporogenes

-

-

2121

-

-

ir

D-proline + dithiol (reduced)

5-aminopentanoic acid + oxidized dithiol

Acetoanaerobium sticklandii

-

-

484934

-

484934

?

D-proline + dithiol (reduced)

5-aminopentanoic acid + oxidized dithiol

Acetoanaerobium sticklandii

-

-

2121

-

2121

ir

D-proline + dithiol (reduced)

5-aminopentanoic acid + oxidized dithiol

Acetoanaerobium sticklandii

-

-

484928

-

484928

ir

D-proline + dithiol (reduced)

5-aminopentanoic acid + oxidized dithiol

Acetoanaerobium sticklandii

-

-

484929

-

-

ir

D-proline + dithiol (reduced)

5-aminopentanoic acid + oxidized dithiol

Acetoanaerobium sticklandii DSM 519

-

-

484934

-

484934

?

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii

-

dithiothreitol as artificial electron donor

484929, 484930, 484932

-

-

ir

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii

-

dithiothreitol as artificial electron donor

484934

-

484934

ir

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii

-

Stickland reaction

484935

-

-

?

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii

-

Stickland reaction

484932

-

-

ir

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii

-

Stickland reaction

484934

-

484934

ir

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii DSM 519

-

dithiothreitol as artificial electron donor

484934

-

484934

ir

D-proline + dithiothreitol

5-amino pentanoic acid + ?

Acetoanaerobium sticklandii DSM 519

-

Stickland reaction

484934

-

484934

ir

D-proline + NADH

5-aminopentanoic acid + NAD+

Acetoanaerobium sticklandii

-

-

484930, 484931

-

-

?

D-proline + NADH

5-aminopentanoic acid + NAD+

Acetoanaerobium sticklandii

-

NADH is more effective than dithiols in crude preparations

484934

-

-

?

D-proline + NADH

5-aminopentanoic acid + NAD+

Acetoanaerobium sticklandii

-

NADH-dependent reduction of D-proline, NADH is the normal physiological electron donor, but the purified enzyme is inactive in presence of NADH in vitro

484929

-

-

?

D-proline + NADH

5-aminopentanoic acid + NAD+

Acetoanaerobium sticklandii DSM 519

-

NADH is more effective than dithiols in crude preparations

484934

-

-

?