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1.20.1.1: phosphonate dehydrogenase

This is an abbreviated version!
For detailed information about phosphonate dehydrogenase, go to the full flat file.

Word Map on EC 1.20.1.1

Reaction

phosphonate
+
NAD+
+
H2O
=
phosphate
+
NADH
+
H+

Synonyms

NAD-dependent phosphite dehydrogenase, NAD:phosphite oxidoreductase, phosphite dehydrogenase, PTDH, PtxD

ECTree

     1 Oxidoreductases
         1.20 Acting on phosphorus or arsenic in donors
             1.20.1 With NAD+ or NADP+ as acceptor
                1.20.1.1 phosphonate dehydrogenase

Temperature Stability

Temperature Stability on EC 1.20.1.1 - phosphonate dehydrogenase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
39
-
wild-type, melting temperature
40
stable below
40.5
-
rapid inactivation, half life less than 10 min, 1 mM NAD+ partially protects against thermal inactivation, E175A/A176R double mutant is readily protected against inactivation by addition of 1 mM NADP+ for at least 15 min
55
complete inactivation
59.3
-
mutant Q137R/I150F/Q215L/R275Q/L276Q/A319E/V315A/Q132R/V71I/E130K/I313L/A325V, melting temperature