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1.2.7.8: indolepyruvate ferredoxin oxidoreductase

This is an abbreviated version!
For detailed information about indolepyruvate ferredoxin oxidoreductase, go to the full flat file.

Word Map on EC 1.2.7.8

Reaction

(indol-3-yl)pyruvate
+
CoA
+ 2 oxidized ferredoxin =
S-2-(indol-3-yl)acetyl-CoA
+
CO2
+ 2 reduced ferredoxin + 2 H+

Synonyms

3-(indol-3-yl)pyruvate synthase (ferredoxin), arylpyruvate-ferredoxin oxidoreductase, hydroxyphenylpyruvate oxidase, indolepyruvate oxidase, indolepyruvate-ferredoxin oxidoreductase, indolepyruvate:Fd oxidoreductase, IOR, phenylpyruvate oxidase, VOR

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.7 With an iron-sulfur protein as acceptor
                1.2.7.8 indolepyruvate ferredoxin oxidoreductase

Systematic Name

Systematic Name on EC 1.2.7.8 - indolepyruvate ferredoxin oxidoreductase

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SYSTEMATIC NAME
IUBMB Comments
3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)
Contains thiamine diphosphate and [4Fe-4S] clusters. Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and p-hydroxyphenylpyruvate as substrates. This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).