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1.2.7.11: 2-oxoacid oxidoreductase (ferredoxin)

This is an abbreviated version!
For detailed information about 2-oxoacid oxidoreductase (ferredoxin), go to the full flat file.

Word Map on EC 1.2.7.11

Reaction

a 2-oxocarboxylate
+
CoA
+ 2 oxidized ferredoxin =
an acyl-CoA
+
CO2
+ 2 reduced ferredoxin + 2 H+

Synonyms

2-ketoacid:ferredoxin oxidoreductase, 2-oxoacid: ferredoxin oxidoreductase, 2-oxoacid:ferredoxin oxidoreductase, 2-oxoacid:ferredoxin oxidoreductases, Ape1473/1472, KOR, OFOR, OFOR1, OFOR2, PFOR, Saci_2306, Saci_2307, StOFOR, StOFOR1, StOFOR2

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.7 With an iron-sulfur protein as acceptor
                1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)

Inhibitors

Inhibitors on EC 1.2.7.11 - 2-oxoacid oxidoreductase (ferredoxin)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-fluoro-7-nitrobenzofurazan
-
0.001 mM inhibitor with 0.01 mM enzyme decreases the activity by about 20% and 0.003 mM inhibitor with 0.01 mM enzyme decreases the activity by around 50%. Inactivation is prevented by CoA
CoA
-
substrate inhibition
KCl
-
10–20% inhibition is observed with 50 mM KCl, while with higher concentrations (maximum, 0.6 M), 46–65% activation is reached, and further increased concentrations of KCl are inhibitory, enzyme Ape1473/1472