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1.2.7.1: pyruvate synthase

This is an abbreviated version!
For detailed information about pyruvate synthase, go to the full flat file.

Word Map on EC 1.2.7.1

Reaction

pyruvate
+
CoA
+
oxidized ferredoxin
=
acetyl-CoA
+
CO2
+
reduced ferredoxin
+ 2 H+

Synonyms

2-ketobutyrate synthase, 2-oxobutyrate (methylviologen), 2-oxobutyrate synthase (benzylviologen), 2-oxobutyrate-ferredoxin oxidoreductase, alpha-ketobutyrate synthase, alpha-ketobutyrate-ferredoxin oxidoreductase, AP120, Ape2126/2128, bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase, EC 1.2.7.2, Moth_0064, NifJ1, OFOR, PFO, PFO A, PFOR, Pfor1, PforA, PFR, PFR1, POR, PorEDABG, pyruvate ferredoxin oxidoreductase, pyruvate-ferredoxin oxidoreductase, pyruvate:Fd oxidoreductase, pyruvate:ferredoxin oxidoreductase, pyruvate:ferredoxin oxidoreductase A, synthase, 2-oxobutyrate, TKV_c04340, Tsac_0046, TTE0445

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.7 With an iron-sulfur protein as acceptor
                1.2.7.1 pyruvate synthase

Reference

Reference on EC 1.2.7.1 - pyruvate synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yoon, K.S.; Ishii, M.; Kodama, T.; Igarashi, Y.
Purification and characterization of pyruvate:ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6
Arch. Microbiol.
167
275-279
1997
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6 / IAM 12695
Manually annotated by BRENDA team
Blamey, J.M.; Adams, M.W.W.
Purification and characterization of pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus
Biochim. Biophys. Acta
1161
19-27
1993
Pyrococcus furiosus
Manually annotated by BRENDA team
Kletzin, A.; Adams, M.W.W.
Molecular and phylogenetic chararcterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima
J. Bacteriol.
178
248-257
1996
Thermotoga maritima (O05651 and Q56317 and O05650 and Q56316), Thermotoga maritima, Pyrococcus furiosus (Q51804 and Q51805 and Q51803 and Q51799), Pyrococcus furiosus, Thermotoga maritima DSM 3109 (O05651 and Q56317 and O05650 and Q56316)
Manually annotated by BRENDA team
Townson, S.M.; Upcroft, J.A.; Upcroft, P.
Characterization and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis
Mol. Biochem. Parasitol.
79
183-193
1996
Giardia intestinalis, Giardia intestinalis BRIS/83/HEPU/106
Manually annotated by BRENDA team
Bock, A.K.; Kunow, J.; Glasemacher, J.; Schnheit, P.
Catalytic properties, molecular composition and sequence alignment of pyruvate:ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina barkeri (strain Fusaro)
Eur. J. Biochem.
237
35-44
1996
Methanosarcina barkeri (P80521 and P80522 and P80523 and P80524), Methanosarcina barkeri, Methanosarcina barkeri DSM 804 (P80521 and P80522 and P80523 and P80524)
Manually annotated by BRENDA team
Kunow, J.; Linder, D.; Thauer, R.K.
Pyruvate:ferredoxin oxidoreductase from the sulfate-reducing Archaeoglobus fulgidus: molecular composition, catalytic properties, and sequence alignments
Arch. Microbiol.
163
21-28
1995
Archaeoglobus fulgidus
Manually annotated by BRENDA team
Lin, W.C.; Yang, Y.L.; Whitman, W.B.
The anabolic pyruvate oxidoreductase from Methanococcus maripaludis
Arch. Microbiol.
179
444-456
2003
Methanococcus maripaludis (Q9P9E5 and Q9P9E4 and Q9P9E6 and Q9P9E7 and Q9P9E3), Methanococcus maripaludis DSM Z 2067 (Q9P9E5 and Q9P9E4 and Q9P9E6 and Q9P9E7 and Q9P9E3)
Manually annotated by BRENDA team
Ikeda, T.; Ochiai, T.; Morita, S.; Nishiyama, A.; Yamada, E.; Arai, H.; Ishii, M.; Igarashi, Y.
Anabolic five subunit-type pyruvate:ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6
Biochem. Biophys. Res. Commun.
340
76-82
2006
Hydrogenobacter thermophilus (D3DJK0 and D3DJJ8), Hydrogenobacter thermophilus TK-6 / IAM 12695 (D3DJK0 and D3DJJ8)
Manually annotated by BRENDA team
Nishizawa, Y.; Yabuki, T.; Fukuda, E.; Wakagi, T.
Gene expression and characterization of two 2-oxoacid:ferredoxin oxidoreductases from Aeropyrum pernix K1
FEBS Lett.
579
2319-2322
2005
Aeropyrum pernix (Q9YA13 and Q9YA11)
Manually annotated by BRENDA team
Vornolt, J.; Kunow, J.; Stetter, K.; Thauer, R.
Enzymes and coenzymes of the carbon monoxide dehydrogenase pathway for autotrophic CO2 fixation in Archaeoglobus lithotrophicus and the lack of carbon monoxide dehydrogenase in the heterotrophic A. profundus
Arch. Microbiol.
163
112-118
1995
Archaeoglobus fulgidus, Archaeoglobus profundus, Archaeoglobus lithotrophicus, Archaeoglobus lithotrophicus TF-2, Archaeoglobus profundus DSM 5631
-
Manually annotated by BRENDA team
Labes, A.; Schoenheit, P.
Sugar utilization in the hyperthermophilic, sulfate-reducing archaeon Archaeoglobus fulgidus strain 7324: starch degradation to acetate and CO2 via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming)
Arch. Microbiol.
176
329-338
2001
Archaeoglobus fulgidus, Archaeoglobus fulgidus 7324
Manually annotated by BRENDA team
Zhou, Z.H.; Adams, M.W.
Site-directed mutations of the 4Fe-ferredoxin from the hyperthermophilic archaeon Pyrococcus furiosus: role of the cluster-coordinating aspartate in physiological electron transfer reactions
Biochemistry
36
10892-10900
1997
Pyrococcus furiosus
Manually annotated by BRENDA team
Menon, A.L.; Hendrix, H.; Hutchins, A.; Verhagen, M.F.; Adams, M.W.
The delta-subunit of pyruvate ferredoxin oxidoreductase from Pyrococcus furiosus is a redox-active, iron-sulfur protein: evidence for an ancestral relationship with 8Fe-type ferredoxins
Biochemistry
37
12838-12846
1998
Pyrococcus furiosus
Manually annotated by BRENDA team
Ma, K.; Hutchins, A.; Sung, S.J.; Adams, M.W.
Pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon, Pyrococcus furiosus, functions as a CoA-dependent pyruvate decarboxylase
Proc. Natl. Acad. Sci. USA
94
9608-9613
1997
Pyrococcus furiosus
Manually annotated by BRENDA team
Leitsch, D.; Burgess, A.G.; Dunn, L.A.; Krauer, K.G.; Tan, K.; Duchene, M.; Upcroft, P.; Eckmann, L.; Upcroft, J.A.
Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
J. Antimicrob. Chemother.
66
1756-1765
2011
Giardia intestinalis
Manually annotated by BRENDA team
Pieulle, L.; Stocker, P.; Vinay, M.; Nouailler, M.; Vita, N.; Brasseur, G.; Garcin, E.; Sebban-Kreuzer, C.; Dolla, A.
Study of the thiol/disulfide redox systems of the anaerobe Desulfovibrio vulgaris points out pyruvate:ferredoxin oxidoreductase as a new target for thioredoxin 1
J. Biol. Chem.
286
7812-7821
2011
Desulfovibrio vulgaris
Manually annotated by BRENDA team
Noth, J.; Krawietz, D.; Hemschemeier, A.; Happe, T.
Pyruvate:ferredoxin oxidoreductase is coupled to light-independent hydrogen production in Chlamydomonas reinhardtii
J. Biol. Chem.
288
4368-4377
2013
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii CC124
Manually annotated by BRENDA team
Emelyanov, V.V.; Goldberg, A.V.
Fermentation enzymes of Giardia intestinalis, pyruvate:ferredoxin oxidoreductase and hydrogenase, do not localize to its mitosomes
Microbiology
157
1602-1611
2011
Giardia intestinalis (Q24982), Giardia intestinalis, Giardia intestinalis WB / CC 30957 (Q24982)
Manually annotated by BRENDA team
Meza-Cervantez, P.; Gonzalez-Robles, A.; Cardenas-Guerra, R.E.; Ortega-Lopez, J.; Saavedra, E.; Pineda, E.; Arroyo, R.
Pyruvate:ferredoxin oxidoreductase (PFO) is a surface-associated cell-binding protein in Trichomonas vaginalis and is involved in trichomonal adherence to host cells
Microbiology
157
3469-3482
2011
Trichomonas vaginalis
Manually annotated by BRENDA team
van Lis, R.; Baffert, C.; Coute, Y.; Nitschke, W.; Atteia, A.
Chlamydomonas reinhardtii chloroplasts contain a homodimeric pyruvate:ferredoxin oxidoreductase that functions with FDX1
Plant Physiol.
161
57-71
2013
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii CC124
Manually annotated by BRENDA team
Eram, M.S.; Oduaran, E.; Ma, K..
The bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase from Thermococcus guaymasensis
Archaea
2014
349379
2014
Thermococcus guaymasensis (W8CQR1 and W8CQB2 and W8CQB1 and W8CR61), Thermococcus guaymasensis, Thermococcus guaymasensis DSM 11113 (W8CQR1 and W8CQB2 and W8CQB1 and W8CR61)
Manually annotated by BRENDA team
Bock, A.K.; Schnheit, P.; Teixeira, M.
The iron-sulfur centers of the pyruvate:ferredoxin oxidoreductase from Methanosarcina barkeri (Fusaro)
FEBS Lett.
414
209-212
1997
Methanosarcina barkeri, Methanosarcina barkeri DSM 804
Manually annotated by BRENDA team
Wang, Q.; Wang, Q.; Tong, W.; Bai, X.; Chen, Z.; Zhao, J.; Zhang, J.; Liu, S.
Regulation of enzyme activity of alcohol dehydrogenase through its interactions with pyruvate-ferredoxin oxidoreductase in Thermoanaerobacter tengcongensis
Biochem. Biophys. Res. Commun.
417
1018-1023
2012
Caldanaerobacter subterraneus subsp. tengcongensis (Q8RCI3), Caldanaerobacter subterraneus subsp. tengcongensis, Caldanaerobacter subterraneus subsp. tengcongensis DSM 15242 (Q8RCI3)
Manually annotated by BRENDA team
Blamey, J.M.; Adams, M.W.
Characterization of an ancestral type of pyruvate ferredoxin oxidoreductase from the hyperthermophilic bacterium, Thermotoga maritima
Biochemistry
33
1000-1007
1994
Thermotoga maritima
Manually annotated by BRENDA team
Smith, E.T.; Blamey, J.M.; Adams, M.W.
Pyruvate ferredoxin oxidoreductases of the hyperthermophilic archaeon, Pyrococcus furiosus, and the hyperthermophilic bacterium, Thermotoga maritima, have different catalytic mechanisms
Biochemistry
33
1008-1016
1994
Thermotoga maritima (O05651 and Q56317 and O05650 and Q56316), Thermotoga maritima, Pyrococcus furiosus (Q51804 and Q51805 and Q51803 and Q51799), Pyrococcus furiosus, Thermotoga maritima DSM 3109 (O05651 and Q56317 and O05650 and Q56316)
Manually annotated by BRENDA team
Forget, P.
Purification and characterization of a heat stable ferredoxin isolated from Clostridium thermocellum
Biochimie
64
1009-1014
1983
Acetivibrio thermocellus
Manually annotated by BRENDA team
Zhou, J.; Olson, D.; Lanahan, A.; Tian, L.; Murphy, S.; Lo, J.; Lynd, L.
Physiological roles of pyruvate ferredoxin oxidoreductase and pyruvate formate-lyase in Thermoanaerobacterium saccharolyticum JW/SL-YS485
Biotechnol. Biofuels
8
138
2015
Thermoanaerobacterium saccharolyticum (I3VRD9), Thermoanaerobacterium saccharolyticum, Thermoanaerobacterium saccharolyticum JW/SL-YS485 (I3VRD9), Thermoanaerobacterium saccharolyticum JW/SL-YS485
Manually annotated by BRENDA team
Nohara, K.; Orita, I.; Nakamura, S.; Imanaka, T.; Fukui, T.
Genetic examination and mass balance analysis of pyruvate/amino acid oxidation pathways in the hyperthermophilic archaeon Thermococcus kodakarensis
J. Bacteriol.
196
3831-3839
2014
Thermococcus kodakarensis (Q5JIJ8 and Q5JIJ7 and Q5JIJ6), Thermococcus kodakarensis
Manually annotated by BRENDA team
Imai, T.; Taguchi, K.; Ogawara, Y.; Ohmori, D.; Yamakura, F.; Ikezawa, H.; Urushiyama, A.
Characterization and cloning of an extremely thermostable, Pyrococcus furiosus-type 4Fe ferredoxin from Thermococcus profundus
J. Biochem.
130
649-655
2001
Thermococcus profundus (Q9HHD4), Thermococcus profundus
Manually annotated by BRENDA team
Eram, M.S.; Wong, A.; Oduaran, E.; Ma, K.
Molecular and biochemical characterization of bifunctional pyruvate decarboxylases and pyruvate ferredoxin oxidoreductases from Thermotoga maritima and Thermotoga hypogea
J. Biochem.
158
459-466
2015
Thermotoga maritima (Q56317 and 05650 and Q56316 and O05651), Thermotoga maritima, Pseudothermotoga hypogea (V9NGI4 and V9NFX1 and V9NGQ2 and V9NHA1), Pseudothermotoga hypogea, Thermotoga maritima DSM 3109 (Q56317 and 05650 and Q56316 and O05651)
Manually annotated by BRENDA team
Smith, E.T.; Odom, L.D.; Awramko, J.A.; Chiong, M.; Blamey, J.
Direct electrochemical characterization of hyperthermophilic Thermococcus celer metalloenzymes involved in hydrogen production from pyruvate
J. Biol. Inorg. Chem.
6
227-231
2001
Thermococcus celer
Manually annotated by BRENDA team
Shaw, A.J.; Podkaminer, K.K.; Desai, S.G.; Bardsley, J.S.; Rogers, S.R.; Thorne, P.G.; Hogsett, D.A.; Lynd, L.R.
Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield
Proc. Natl. Acad. Sci. USA
105
13769-13774
2008
Thermoanaerobacterium saccharolyticum
Manually annotated by BRENDA team
Takenaka, M.; Yoon, K.S.; Matsumoto, T.; Ogo, S.
Acetyl-CoA production by encapsulated pyruvate ferredoxin oxidoreductase in alginate hydrogels
Biores. Technol.
227
279-285
2017
Citrobacter sp.
Manually annotated by BRENDA team
Saranyah, K.; Kalva, S.; Mukund, N.; Singh, S.K.; Saleena, L.M.
Homology modeling and in silico site directed mutagenesis of pyruvate ferredoxin oxidoreductase from Clostridium thermocellum
Comb. Chem. High Throughput Screen.
18
975-989
2015
Acetivibrio thermocellus
Manually annotated by BRENDA team
Song, H.O.
Influence of 120 kDa pyruvate:ferredoxin oxidoreductase on pathogenicity of Trichomonas vaginalis
Korean J. Parasitol.
54
71-74
2016
Trichomonas vaginalis
Manually annotated by BRENDA team
Kushkevych, I.V.
Kinetic properties of pyruvate ferredoxin oxidoreductase of intestinal sulfate-reducing bacteria Desulfovibrio piger Vib-7 and Desulfomicrobium sp. Rod-9
Pol. J. Microbiol.
64
107-114
2015
Desulfovibrio piger, Desulfomicrobium sp., Desulfomicrobium sp. Rod-9, Desulfovibrio piger Vib-7
Manually annotated by BRENDA team
Bock, A.; Kunow, J.; Glasemacher, J.; Schnheit, P.
Catalytic properties, molecular composition and sequence alignments of pyruvate ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina barkeri (strain Fusaro)
Eur. J. Biochem.
237
35-44
1996
Methanosarcina barkeri (P80521 and P80522 and P80523 and P80524), Methanosarcina barkeri, Methanosarcina barkeri DSM 804 (P80521 and P80522 and P80523 and P80524)
Manually annotated by BRENDA team
Adams, M.; Holden, J.; Menon, A.; Schut, G.; Grunden, A.; Hou, C.; Hutchins, A.; Jenney F.E., J.; Kim, C.; Ma, K.; Pan, G.; Roy, R.; Sapra, R.; Story, S.; Verhagen, M.
Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
183
716-724
2001
Pyrococcus furiosus
Manually annotated by BRENDA team
Patil, Y.; Junghare, M.; Mller, N.
Fermentation of glycerol by Anaerobium acetethylicum and its potential use in biofuel production
Microb. Biotechnol.
10
203-217
2017
Anaerobium acetethylicum
Manually annotated by BRENDA team
Warren, C.A.; van Opstal, E.; Ballard, T.E.; Kennedy, A.; Wang, X.; Riggins, M.; Olekhnovich, I.; Warthan, M.; Kolling, G.L.; Guerrant, R.L.; Macdonald, T.L.; Hoffman, P.S.
Amixicile, a novel inhibitor of pyruvate ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model
Antimicrob. Agents Chemother.
56
4103-4111
2012
Clostridioides difficile, Clostridioides difficile ATCC 43255
Manually annotated by BRENDA team
Witt, A.; Pozzi, R.; Diesch, S.; Haedicke, O.; Grammel, H.
New light on ancient enzymes - in vitro CO2 fixation by pyruvate synthase of Desulfovibrio africanus and Sulfolobus acidocaldarius
FEBS J.
286
4494-4508
2019
Desulfocurvibacter africanus (P94692), Desulfocurvibacter africanus
Manually annotated by BRENDA team
Katsyv, A.; Schoelmerich, M.C.; Basen, M.; Mueller, V.
The pyruvate ferredoxin oxidoreductase of the thermophilic acetogen, Thermoanaerobacter kivui
FEBS open bio
11
1332-1342
2021
Thermoanaerobacter kivui (A0A097APA2), Thermoanaerobacter kivui
Manually annotated by BRENDA team
Nisa, K.; Ashraf, S.; Siddiqui, M.; Taj, N.; Habib-Ur-Rehma, H.; Bano, A.; Rashid, N.
Purification and characterization of a thermostable pyruvate ferredoxin oxidoreductase/pyruvate decarboxylase from Thermococcus kodakaraensis
Pak. J. Zool.
52
1149-1156
2020
Thermococcus kodakarensis
-
Manually annotated by BRENDA team
Chen, P.Y.; Aman, H.; Can, M.; Ragsdale, S.W.; Drennan, C.L.
Binding site for coenzyme A revealed in the structure of pyruvate ferredoxin oxidoreductase from Moorella thermoacetica
Proc. Natl. Acad. Sci. USA
115
3846-3851
2018
Moorella thermoacetica (Q2RMD6)
Manually annotated by BRENDA team