1.2.3.3: pyruvate oxidase
This is an abbreviated version!
For detailed information about pyruvate oxidase, go to the full flat file.
Word Map on EC 1.2.3.3
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1.2.3.3
-
streptococcus
-
thiamin
-
plantarum
-
sanguinis
-
pneumococcus
-
lipid-activated
-
acetohydroxy
-
diphosphate-dependent
-
phosphotransacetylase
-
synthesis
-
oralis
-
analysis
-
medicine
- 1.2.3.3
- streptococcus
- thiamin
- plantarum
- sanguinis
-
pneumococcus
-
lipid-activated
-
acetohydroxy
-
diphosphate-dependent
- phosphotransacetylase
- synthesis
- oralis
- analysis
- medicine
Reaction
Synonyms
acetyl phosphate-producing pyruvate oxidase, phosphate-dependent pyruvate oxidase, POD, POX, POX-2, poxB, PoxF, PyOD, PyrOx, pyruvate oxidase, pyruvate:oxygen-2-oxidoreductase (phosphorylating), pyruvic oxidase, SpxB, SpxB protein
ECTree
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Systematic Name
Systematic Name on EC 1.2.3.3 - pyruvate oxidase
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pyruvate:oxygen 2-oxidoreductase (phosphorylating)
A flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin. FADH2 is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate [2].