1.2.3.1: aldehyde oxidase
This is an abbreviated version!
For detailed information about aldehyde oxidase, go to the full flat file.
Word Map on EC 1.2.3.1
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1.2.3.1
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xanthine
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molybdenum
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allopurinol
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oxidases
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menadione
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benzaldehyde
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abscisic
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n-oxide
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n-heterocyclic
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moco
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phthalazine
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raloxifene
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molybdenum-containing
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xanthinuria
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hydralazine
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oxidase-mediated
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drug-drug
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molybdoenzymes
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sulphite
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o6-benzylguanine
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molybdopterin
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flavin-containing
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disulfiram
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n1-methylnicotinamide
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oxypurinol
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nutrition
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medicine
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hypouricemia
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amidoxime
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oxidase-catalyzed
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pharmacology
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synthesis
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degradation
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cyp2a6
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nitroreduction
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imidacloprid
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neonicotinoids
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phenanthridine
- 1.2.3.1
- xanthine
- molybdenum
- allopurinol
- oxidases
- menadione
- benzaldehyde
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abscisic
- n-oxide
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n-heterocyclic
- moco
- phthalazine
- raloxifene
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molybdenum-containing
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xanthinuria
- hydralazine
-
oxidase-mediated
-
drug-drug
-
molybdoenzymes
- sulphite
- o6-benzylguanine
- molybdopterin
-
flavin-containing
- disulfiram
- n1-methylnicotinamide
- oxypurinol
- nutrition
- medicine
-
hypouricemia
-
amidoxime
-
oxidase-catalyzed
- pharmacology
- synthesis
- degradation
- cyp2a6
-
nitroreduction
- imidacloprid
-
neonicotinoids
- phenanthridine
Reaction
Synonyms
Aao4, AHO2, aldehyde oxidase 1, aldehyde oxidase 2, aldehyde oxidase 3, aldehyde oxidase 3-like 1, aldehyde oxidase 4, aldehyde-oxygen oxidoreductase, aldehyde:oxygen oxidoreductase, ALOD, AlOx, antennae-specific aldehyde oxidase, AO, AO-alpha, AO-beta, AO-delta, AO-gamma, AO-kappa, AO1, AO2, AO3, AO4, AOH, AOH1, AOH2, AOH3, AOMM, AOR, AOX, AOX1, AOX2, AOX3, AOX4, AtraAOX2, EC 1.2.3.11, FOD, formate oxidase, IAO1, mAOX3, mouse liver aldehyde oxidase 3, quinoline oxidase, Retinal oxidase, retinene oxidase
ECTree
1.2.3.1 aldehyde oxidaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.2.3.1 - aldehyde oxidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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preadipocytes have a very low expression of AOX1, in 2 days differentiated cells AOX1 is induced and is not further upregulated in 3, 7 and 9 days differentiated cells. AOX1 mRNA is nearly four-fold higher in 2 days differentiated cells when compared to preadipocytes and doubles from days 2 to 6
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isoform AOX1 mRNA is higher in visceral compared to subcutaneous adipose tissue, Aox1 protein is detected in both fat depots
isoform AO1 is expressed in the developing rice grains at 1, 7, and 21 days after flowering
richest source of AOH2 mRNA in the adult mouse is the inner ear
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hepatoma cell line, induction of enzyme isoform AOX1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin
mRNA is highly expressed in the lymphoid organ and intestinal tissues
mRNA is highly expressed in the lymphoid organ and intestinal tissues
only tissue examined with singificant levels of transcript
specific expression of enzyme in chemosensory organs, with strongest expression in antennae
in kidney proximal tubular epithelial cells, ABCA1 and AOX1 are coexpressed
during the early stages of seed development, the aldehyde oxidase activity in seeds is almost exclusively restricted to the seed coat
very large amounts of AOH2 are predicted to be present during the early stages of development and specifically in the zygote
additional information
AOX1 appears to be strongly expressed in antennae of both sexes, whereby intensities are clearly higher in male than in female antennae. It is predominantly expressed at the end of the pupal stage and during adult life. AOX1 is restricted to the sensilla side of the antennal branch
AOX2 appears to be strongly expressed in antennae of both sexes, whereby intensities are clearly higher in male than in female antennae. It is predominantly expressed at the end of the pupal stage and during adult life. AOX2 is restricted to the sensilla side of the antennal branch. AOX2 is associated in males with the bombykalsensitive sensilla
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AOX1 appears to be strongly expressed in antennae of both sexes, whereby intensities are clearly higher in male than in female antennae. It is predominantly expressed at the end of the pupal stage and during adult life. AOX1 is restricted to the sensilla side of the antennal branch
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AOX2 appears to be strongly expressed in antennae of both sexes, whereby intensities are clearly higher in male than in female antennae. It is predominantly expressed at the end of the pupal stage and during adult life. AOX2 is restricted to the sensilla side of the antennal branch. AOX2 is associated in males with the bombykalsensitive sensilla
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specific expression of enzyme in chemosensory organs, with strongest expression in antennae
AOH2 and AOH3 mRNAs are expressed in the brain at much lower levels than AOX1 and AOH1
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presence of the AOX1 transcript in the glial cell population of the spinal cord
AOX1 mRNA is particularly abundant in the epithelial layer
drastic drought imposed on rosette leaves results in a 19.5fold enhancement of Aao4 transcript
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enzyme activity in wild-type, no activity in Moco sulfurase mutant flacca
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390376, 390388, 390390, 390396, 390399, 390401, 390402, 654034, 654035, 675324, 677111, 692052, 698231, 699237, 740139
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strong AOX1 expression in normal liver, and in cirrhosis. Hepatocellular carcinomas show either a complete loss or reduced expression of AOX1
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male liver has about 7fold higher content of enzyme than that in female, gender specific regulation in the hepatic tissue
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enzyme isoform AOX1 and ite homologue AOH1 are induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin
AOH2 is also present. Aldehyde oxidase activity shows higher levels in male than female adult mice
the AOH1 transcript is already detectable in newborn mice
the AOX1 transcript takes time to appear and is measurable only in the fully developed animal
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390376, 390380, 390385, 390388, 390389, 390391, 390393, 390394, 390397, 390398, 390399, 390400, 390401, 390402, 390403, 390404, 390411, 390412, 390413, 390414, 390416, 390417, 390418, 390423, 673058, 698231
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390370, 390374, 390380, 390388, 390399, 390415, 672548, 673058, 691162, 693075, 695270, 711490, 712399, 726542, 762959
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induction of enzyme by high-fat diet, but not by free fatty acids or leptin
distribution of the activity is uneven, being seen mainly in the pericentral rather than the periportal area
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postnatal day 1, 7 and 14 rats show little or no liver aldehyde oxidase activity. Activity is markedly increased in liver cytosol from rats after postnatal day 14 and is then maintained up to 6 weeks
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enzyme activity in wild-type, no activity in Moco sulfurase mutant flacca
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enzymic activity in young nodules, preferential expression of enzyme in in lateral meristemaitc zone. Strong expression of isoforms I and II, low expression of isoform III
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enzymic activity in mature nodules, preferential expression of enzyme in meristematic and invasion zones. Strong expression of isoform I, low expression of isoforms II and III
in mature dry seeds, aldehyde oxidase activity and expression of is restricted to the embryonic tissues
additional information
detectable amounts of enzyme also in eye, kidney, thymus, testis, duodenum, heart and esophagus
additional information
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detectable amounts of enzyme also in eye, kidney, thymus, testis, duodenum, heart and esophagus
additional information
completely devoid of liver aldehyde oxidase activity
additional information
completely devoid of liver aldehyde oxidase activity
additional information
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isoforms AOX3 and 4 are detected broadly in all tested tissues
additional information
in adrenocortical cells, ABCA1 and AOX1 are coexpressed. Absent from skeletal muscle, small intestine, MCF-7, PC3, CaCo-2, and HT-29 cells
additional information
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in adrenocortical cells, ABCA1 and AOX1 are coexpressed. Absent from skeletal muscle, small intestine, MCF-7, PC3, CaCo-2, and HT-29 cells
additional information
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AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
additional information
AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
additional information
AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
additional information
AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
additional information
AOH2 is abundant in the Harderian gland. AOH3 is restricted to the Bowman's gland
