1.2.1.99: 4-(gamma-glutamylamino)butanal dehydrogenase
This is an abbreviated version!
For detailed information about 4-(gamma-glutamylamino)butanal dehydrogenase, go to the full flat file.
Reaction
Synonyms
ALDH, gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [NAD(P)+], NAD+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase, PuuC
ECTree
1.2.1.99 4-(gamma-glutamylamino)butanal dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.2.1.99 - 4-(gamma-glutamylamino)butanal dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-furaldehyde + NAD+ + H2O
furan-2-carboxylate + NADH + 2 H+
-
22% of the activity with 3-hydroxypropionaldehyde
-
-
?
3-hydroxypropionaldehyde + NADP+ + H2O
3-hydroxypropanoate + NADPH + 2 H+
activity is decreased by 73% when NAD+ is replaced with NADP+. The reduction of 3-hydroxypropionate to 3-hydroxypropionaldehyde is not catalyzed with NADPH as cofactor
-
-
ir
4-(gamma-L-glutamylamino)butanal + NAD+ + H2O
4-(gamma-L-glutamylamino)butanoate + NADH + H+
-
-
-
?
gamma-glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O
4-(glutamylamino) butanoate + NADH + 2 H+
the enzyme is involved in degradation of putrescine
-
-
?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
-
-
-
?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
activity for the reduction of 3-hydroxypropionate to 3-hydroxypropionaldehyde is only 4% of that for the corresponding oxidation reaction, indicating that this enzyme catalyzes oxidation reactions under most physiological conditions
-
-
r
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
-
-
-
-
?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
-
the enzyme might play a role in putresine and propionate metabolism
-
-
?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
-
3-hydroxypropionaldehyde i.e. 3-HPA, 3-hydroxypropionic acid i.e. 3-HP, PuuC overexpression enhances the glycerol carbon flux towards 3-hydroxypropionaldehyde
-
-
?
3-hydroxypropionaldehyde + NAD+ + H2O
3-hydroxypropanoate + NADH + 2 H+
-
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
35% of the activity with 3-hydroxypropionaldehyde
-
-
?
isovaleraldehyde + NAD+ + H2O
3-methylbutanoate + NADH + 2 H+
-
-
-
?
isovaleraldehyde + NAD+ + H2O
3-methylbutanoate + NADH + 2 H+
-
-
-
-
?
valeraldehyde + NAD+ + H2O
pentanoate + NADH + H+
most preferred substrate
-
-
?
valeraldehyde + NAD+ + H2O
pentanoate + NADH + H+
-
most preferred substrate
-
-
?
additional information
?
-
enzyme additionally displays the activity of EC 1.2.1.24, succinate-semialdehyde dehydrogenase (NAD+)
-
-
?
additional information
?
-
-
development and evaluation recombinant Klebsiella pneumoniae, for the production of 3-hydroxypropionic acid from glycerol, therefor PuuC together with a coenzyme B12-dependent glycerol dehydratase are overexpressed while two major oxidoreductases, DhaT and YqhD, are disrupted eliminating the production of 1,3-propanediol out of 3-hydroxypropionaldehyde
-
-
?
