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1.2.1.85: 2-hydroxymuconate-6-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about 2-hydroxymuconate-6-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.85

Reaction

2-hydroxymuconate-6-semialdehyde
+
NAD+
 +
H2O
=
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate
 +
NADH
 + 2 H+

Synonyms

2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, 5C-2HMS dehydrogenase, HMS dehydrogenase, NAD+-dependent 2-hydroxy-muconic 6-semialdehyde dehydrogenase, NahI, praB, XylG

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase

KM Value

KM Value on EC 1.2.1.85 - 2-hydroxymuconate-6-semialdehyde dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0093
2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate
-
in 100 mM Tris-HCl, pH 8.5, at 25°C
0.0013 - 0.017
2-hydroxymuconate-6-semialdehyde
1.3
3-Chlorobenzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.17
3-Fluorobenzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.94
3-Methoxybenzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.63
3-methylbenzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.81
3-Nitrobenzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.53
4-methylbenzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.46
benzaldehyde
-
in 100 mM glycine-NaOH (pH 9.2), at 25°C
0.33
NAD+
-
in the presence of benzaldehyde, 100 mM glycine-NaOH (pH 9.2), at 25°C
additional information
additional information
Michaelis-Menten kinetics
-