1.2.1.79: succinate-semialdehyde dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.2.1.79
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1.2.1.79
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ssadhs
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nad+
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dehydrogenases
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tricarboxylic
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cyanobacterium
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2-oxoglutarate
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adduct
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moss
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tca
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syntrichia
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shunt
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synechococcus
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medicine
- 1.2.1.79
- ssadhs
- nad+
- dehydrogenases
-
tricarboxylic
- cyanobacterium
- 2-oxoglutarate
- adduct
-
moss
- tca
-
syntrichia
-
shunt
- synechococcus
- medicine
Reaction
Synonyms
AbSSADH, ALDH21, all3556, ApSSADH, gabD, GabD1, NADP+-dependent SSADH, NADP+-dependent succinic semialdehyde dehydrogenase, NADP-dependent succinic semialdehyde dehydrogenase, PpSSALDH, slr0370, Sp2771, SpSSADH, SSADH, SSADH-II, SSALDH, SSO1842, succinic semialdehy de dehydrogenase, succinic semialdehyde dehydrogenase, SYNPCC7002_A2771, SySSADH
ECTree
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Reaction
Reaction on EC 1.2.1.79 - succinate-semialdehyde dehydrogenase (NADP+)
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succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+
proposed reaction mechanism of AbSSADH via thiohemiacetal intermediate and thioester intermediate. Formation of Cys289 thiolate is necessary for the activity of AbSSADH. Based on two independent methods of pKa measurement, the pKa of Cys289 is 7.4-7.9. The rate-limiting step of the overall reaction of AbSSADH are the thioester intermediate hydrolysis and product liberation steps
succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+
the thiol-group of Cys residue in aldehyde dehydrogenase will attack NADP+ to form the adduct is the first step in the catalytic mechanism. The key step is the formation of thiohemiacetal tetrahedral intermediate, which then is converted to thioester intermediate by transferring the hydride to NAD(P)+, catalytic reaction kinetic analysis
succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+
two arginine residues at positions 121 and 457 are both essential for the catalytic activity of ALDH21 and for the binding of SSAL