1.2.1.79: succinate-semialdehyde dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.2.1.79
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1.2.1.79
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ssadhs
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nad+
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dehydrogenases
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tricarboxylic
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cyanobacterium
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2-oxoglutarate
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adduct
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moss
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tca
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syntrichia
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shunt
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synechococcus
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medicine
- 1.2.1.79
- ssadhs
- nad+
- dehydrogenases
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tricarboxylic
- cyanobacterium
- 2-oxoglutarate
- adduct
-
moss
- tca
-
syntrichia
-
shunt
- synechococcus
- medicine
Reaction
Synonyms
AbSSADH, ALDH21, all3556, ApSSADH, gabD, GabD1, NADP+-dependent SSADH, NADP+-dependent succinic semialdehyde dehydrogenase, NADP-dependent succinic semialdehyde dehydrogenase, PpSSALDH, slr0370, Sp2771, SpSSADH, SSADH, SSADH-II, SSALDH, SSO1842, succinic semialdehy de dehydrogenase, succinic semialdehyde dehydrogenase, SYNPCC7002_A2771, SySSADH
ECTree
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KM Value
KM Value on EC 1.2.1.79 - succinate-semialdehyde dehydrogenase (NADP+)
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0.551
Glutaric semialdehyde
recombinant wild-type enzyme, pH 8.2, 25°C, with NADP+
5.37
NAD+
recombinant wild-type enzyme, pH 8.2, 25°C, with succinate semialdehyde
8.44
NAD+
recombinant mutant R228A, pH 8.2, 25°C, with succinate semialdehyde
0.0092
steady-state parameter, 50 microM NADP+ and 10 mM Mg2+, at pH 7.5 and 37°C
0.024
NADP+
recombinant wild-type enzyme, pH 8.2, 25°C, with succinate semialdehyde
0.0613
NADP+
steady-state parameter, 50 microM NADP+, at pH 7.5 and 37°C
0.375
NADP+
recombinant mutant R228A, pH 8.2, 25°C, with succinate semialdehyde
0.00395
succinate semialdehyde
recombinant enzyme, pH 7.0, 30°C
0.01
succinate semialdehyde
pH 9.7, 45°C, recombinant detagged enzyme
0.01694
succinate semialdehyde
in 100 mM sodium phosphate buffer, pH 8.0, 30°C
0.127
succinate semialdehyde
recombinant mutant R228A, pH 8.2, 25°C, with NADP+
0.127
succinate semialdehyde
recombinant mutant Y296A, pH 8.2, 25°C, with NADP+
0.135
succinate semialdehyde
recombinant mutant R457A, pH 8.2, 25°C, with NADP+
0.181
succinate semialdehyde
recombinant wild-type enzyme, pH 8.2, 25°C, with NADP+
0.268
succinate semialdehyde
recombinant mutant R121A, pH 8.2, 25°C, with NADP+
1.49
succinate semialdehyde
recombinant mutant N175A, pH 8.2, 25°C, with NADP+
0.003
steady-state parameter, 200 microM succinic semialdehyde and 10 mM Mg2+, at pH 7.5 and 37°C
0.0133
Succinic semialdehyde
steady-state parameter, 200 microM succinic semialdehyde, at pH 7.5 and 37°C
additional information
Michaelis-Menten kinetics
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additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
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Michaelis-Menten kinetics
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additional information
additional information
enzyme does not obey Michaelis-Menten kinetics
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additional information
additional information
the Km-value of succinate semialdehyde estimated to be far less than 0.05 mM
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additional information
additional information
steady-state kinetic analysis. Pre-steady-state kinetics show burst kinetics for NADPH formation in SSADH, indicating that the rate-limiting step is associated with steps that occur after the hydride transfer. Detection of burst kinetics of NADPH production by pre-steady-state analysis indicates that the rate-limiting step of the AbSSADH reaction occurs after the hydride transfer step
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additional information
additional information
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steady-state kinetic analysis. Pre-steady-state kinetics show burst kinetics for NADPH formation in SSADH, indicating that the rate-limiting step is associated with steps that occur after the hydride transfer. Detection of burst kinetics of NADPH production by pre-steady-state analysis indicates that the rate-limiting step of the AbSSADH reaction occurs after the hydride transfer step
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