1.2.1.76: succinate-semialdehyde dehydrogenase (acylating)
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Synonyms
Tneu_0421
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Systematic Name
Systematic Name on EC 1.2.1.76 - succinate-semialdehyde dehydrogenase (acylating)
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succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].