1.2.1.75: malonyl-CoA reductase (malonate semialdehyde-forming)
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For detailed information about malonyl-CoA reductase (malonate semialdehyde-forming), go to the full flat file.
Reaction
Synonyms
bi-functional malonyl-CoA reductase, malonate semialdehyde reductase, malonate-semialdehyde dehydrogenase, malonyl CoA reductase (malonate semialdehyde-forming), malonyl-CoA reductase, MCR, More, MSAR
ECTree
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Cofactor
Cofactor on EC 1.2.1.75 - malonyl-CoA reductase (malonate semialdehyde-forming)
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NADPH
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NADPH
the NADPH cofactor bound in MCR N-terminal domain is stabilized by hydrogen bonds with the side chains of Arg55, Arg59, Asp84, Asn151, Tyr744 and Lys195, and the main chains of Asn34, Leu35, Gly85, Asn111, Gly113 and Ile224, and by interaction with C-terminal resdiues by hydrogen bonds with the side chains of Ser88, Arg611, Arg612, Asp646, Tyr744 and Lys748, and the main chains of Ser588, Ala589, Ile591, Arg611, Arg612, Val647, Asn673 and Val776, cofactor binding site structure, overview