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1.2.1.59: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)

This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating), go to the full flat file.

Word Map on EC 1.2.1.59

Reaction

D-glyceraldehyde 3-phosphate
+
phosphate
+
NAD(P)+
=
3-phospho-D-glyceroyl phosphate
+
NAD(P)H
+
H+

Synonyms

cgap, chloroplast glyceraldehyde-3-phosphate dehydrogenase, CjGAPDH, Dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide (phosphate)), GAP, GapA, GapB, GAPC, GAPDH, GAPDH2, GBS GAPDH, glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)), NAD(NADP)-dependent glyceraldehyde-3-phosphate dehydrogenase, NAD(P)-dependent G3P dehydrogenase, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent glyceraldehyde 3-phosphate dehydrogenase, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent glyceraldehydephosphate dehydrogenase, pcal_0632, phosphorylating glyceraldehyde-3-phosphate dehydrogenase, STK_13560, Triosephosphate dehydrogenase (NAD(P)), Tsac_2486

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)

Inhibitors

Inhibitors on EC 1.2.1.59 - glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-phospho-D-glyceroyl phosphate
-
ATP
-
activates NADP+-dependent activity, inhibits NAD+-dependent activity
D-glyceraldehyde 3-phosphate
-
GuHCl
the enzyme retains more than 50% activity after 72 h of incubation in the presence of 4 M GuHCl, and 15% at 6 M GuHCl
protein CP12
the enzyme GapDH interacts with the intrinsically disordered protein CP12, when oxidized but not when reduced, in chloroplasts forming a stable complex. In this bienzyme complex, the activity of ADK3 is unchanged while the NADPH-dependent activity of GAPDH is significantly inhibited. CP12 acts as a chaperone for GAPDH. The NADH-dependent activity of the chloroplast GAPDH is not affected by incubation at 4°C, for between 1 and 14 h, with either oxidized ADK3 (OxADK3) or ADK3-DELTACP12 at a ratio of 2 :1 (dimeric ADK : tetrameric GAPDH). When incubated with ADK3, about 63% of the NADPH-dependent activity of GAPDH disappear and this activity is recovered by DTT. Enzyme-ADK3 interaction analysis, overview
-
Urea
the enzyme retains more than 50% activity after 72 h of incubation in the presence of 6 M urea, and 40% at 8 M urea
additional information
-