1.2.1.5: aldehyde dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about aldehyde dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.2.1.5
-
1.2.1.5
-
aldhs
-
retinoic
-
disulfiram
-
alcohol-induced
-
benzaldehyde
-
nadp+-dependent
-
retinaldehyde
-
cyanamide
-
meta-cleavage
-
aldh2*2
-
phosphotransacetylase
-
1.2.1.3
-
hangover
-
alcohol-related
-
medicine
-
energy production
-
synthesis
-
analysis
-
degradation
- 1.2.1.5
-
aldhs
-
retinoic
- disulfiram
-
alcohol-induced
- benzaldehyde
-
nadp+-dependent
- retinaldehyde
- cyanamide
-
meta-cleavage
-
aldh2*2
- phosphotransacetylase
-
1.2.1.3
-
hangover
-
alcohol-related
- medicine
- energy production
- synthesis
- analysis
- degradation
Reaction
Synonyms
acetaldehyde dehydrogenase, ALD4, aldehyde dehydrogenase, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde: NAD(P)+ oxidoreductase, ALDH, ALDH1, ALDH13, ALDH17, ALDH1a, ALDH1A1, Aldh1a3, ALDH1b, ALDH2, ALDH2a, ALDH2b, ALDH3, ALDH3A1, Aldh3b1, ALDH3F1, ALDH3H1, ALDH3I1, ALDH7B7, ALDH9, ALDHC, ALDHIII, BcALDH, BCP54, chromosomally encoded box pathway ALDH, class 3 aldehyde dehydrogenase, Corneal 15.8 kDa protein, Corneal protein 54, dehydrogenase, aldehyde (nicotinamide adenine dinucleotide (phosphate)), HTC-ALDH, K-ACDH, MI dehydrogenase, More, myo-inositol dehydrogenase, NAD(P)(+)-dependent aldehyde dehydrogenase, NAD(P)+-dependent aldehyde dehydrogenase, NAD+-dependent Ald4, nicotinprotein aldehyde dehydrogenase, OsALDH2-1, OsALDH2-2, OsALDH2-3, OsALDH2-4, OsALDH2-5, OsALDH22, OsALDH3-1, OsALDH3-2, OsALDH3-3, OsALDH3-4, OsALDH3-5, OsALDH5, OsALDH7, PEG-ALDH, PuuC, ST0064, succinic semialdehyde dehydrogenase, Transparentin, Tumor-associated aldehyde dehydrogenase, ybcD
ECTree
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]Advanced search results
results (
results (Reference
top
Reference on EC 1.2.1.5 - aldehyde dehydrogenase [NAD(P)+]
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Izaguirre, G.; Pietruszko, R.; Cho, S.; MacKerell, A.D., Jr.
Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs
J. Biomol. Struct. Dyn.
19
429-447
2001
Homo sapiens
Downes, J.E.; Holmes, R.S.
Purification and properties of murine corneal aldehyde dehydrogenase
Biochem. Mol. Biol. Int.
30
525-535
1993
Mus musculus
Choi, S.D.; Joo, C.N.
Purification and characterization of the bovine cerebral mitochondrial aldehyde dehydrogenase
Korean Biochem. J.
24
224-230
1991
Bos taurus
-
King, G.; Holmes, R.S.
Human corneal aldehyde dehydrogenase: purification, kinetic characterisation and phenotypic variation
Biochem. Mol. Biol. Int.
31
49-63
1993
Homo sapiens
Wang, X.; Mann, C.J.; Bai, Y.; Ni, L.; Weiner, H.
Molecular cloning, characterization, and potential roles of cytosolic and mitochondrial aldehyde dehydrogenases in ethanol metabolism in Saccharomyces cerevisiae
J. Bacteriol.
180
822-830
1998
Saccharomyces cerevisiae
Sreerama, L.; Sladek, N.E.
Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance
Biochem. Pharmacol.
45
2487-2505
1993
Homo sapiens
Senior, d.J.; Tasi, C.S.
Purification and characterization of aldehyde dehydrogenase from rat liver mitochondria
Arch. Biochem. Biophys.
262
211-220
1988
Rattus norvegicus
Evces, S.; Lindahl, R.
Characterization of rat cornea aldehyde dehydrogenase
Arch. Biochem. Biophys.
274
518-524
1989
Rattus norvegicus
Jeng, J.; Weiner, H.
Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli
Arch. Biochem. Biophys.
289
214-222
1991
Rattus norvegicus
Rietveld, E.C.; de Zwart, M.; Cox, P.G.F.; Seutter-Berlage, F.
Substituent effects during the rat liver aldehyde dehydrogenase catalyzed oxidation of aromatic aldehydes
Biochim. Biophys. Acta
914
162-169
1987
Rattus norvegicus, Saccharomyces cerevisiae
Lindahl, R.; Baggett, D.W.; Winters, A.L.
Characterization of aldehyde dehydrogenase from HTC rat hepatoma cells
Biochim. Biophys. Acta
843
180-185
1985
Rattus norvegicus
Eckfeldt, J.H.; Yonetani, T.
Isozymes of aldehyde dehydrogenase from horse liver
Methods Enzymol.
89
474-479
1982
Equus caballus
Tamaki, N.; Hama, T.
Aldehyde dehydrogenase from bakers yeast
Methods Enzymol.
89
469-473
1982
Saccharomyces cerevisiae
Tamaki, N.; Nakamura, M.; Kimura, K.; Hama, T.
Purification and properties of aldehyde dehydrogenase from Saccharomyces cerevisiae
J. Biochem.
82
73-79
1977
Saccharomyces cerevisiae
Bostian, K.A.; Betts, G.F.
Kinetics and reaction mechanism of potassium-activated aldehyde dehydrogenase from Saccharomyces cerevisiae
Biochem. J.
173
787-798
1978
Saccharomyces cerevisiae
Eckfeldt, J.; Mope, L.; Takio, K.; Yonetani, T.
Horse liver aldehyde dehydrogenase. Purification and characterization of two isozymes
J. Biol. Chem.
251
236-240
1976
Equus caballus
Perozich, J.; Kuo, I.; Wang, B.C.; Boesch, J.S.; Hempel, J.
Shifting the NAD/NADP preference in class 3 aldehyde dehydrogenase
Eur. J. Biochem.
267
6197-6203
2000
Rattus norvegicus
Schraeder, T.; Zernt, G.; Andreesen, J.R.
NAD(P)-dependent aldehyde dehydrogenase induced during growth of Ralstonia eutropha strain Bo on tetrahydrofurfuryl alcohol
J. Bacteriol.
183
7408-7411
2001
Cupriavidus necator, Cupriavidus necator Bo
Yamanaka, Y.; Kazuoka, T.; Yoshida, M.; Yamanaka, K.; Oikawa, T.; Soda, K.
Thermostable aldehyde dehydrogenase from psychrophile, Cytophaga sp. KUC-1: enzymological characteristics and functional properties
Biochem. Biophys. Res. Commun.
298
632-637
2002
Cytophaga sp. (Q8KZT4)
Boubekeur, S.; Camougrand, N.; Bunoust, O.; Rigoulet, M.; Guerin, B.
Participation of acetaldehyde dehydrogenases in ethanol and pyruvate metabolism of the yeast Saccharomyces cerevisiae
Eur. J. Biochem.
268
5057-5065
2001
Saccharomyces cerevisiae
Oikawa, T.; Kazuoka, T.; Soda, K.
Paradoxical thermostable enzymes from psychrophile: molecular characterization and potentiality for biotechnological application
J. Mol. Catal. B
23
65-70
2003
Cytophaga sp.
-
Ohta, T.; Tani, A.; Kimbara, K.; Kawai, F.
A novel nicotinoprotein aldehyde dehydrogenase involved in polyethylene glycol degradation
Appl. Microbiol. Biotechnol.
68
639-646
2005
Sphingopyxis macrogoltabida, Sphingopyxis macrogoltabida 103
Maestre, O.; Garcia-Martinez, T.; Peinado, R.A.; Mauricio, J.C.
Effects of ADH2 overexpression in Saccharomyces bayanus during alcoholic fermentation
Appl. Environ. Microbiol.
74
702-707
2008
Lacticaseibacillus casei BL23
Glatt, H.; Rost, K.; Frank, H.; Seidel, A.; Kollock, R.
Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1
Arch. Biochem. Biophys.
477
196-205
2008
Homo sapiens (P30838)
Ho, K.K.; Mukhopadhyay, A.; Li, Y.F.; Mukhopadhyay, S.; Weiner, H.
A point mutation produced a class 3 aldehyde dehydrogenase with increased protective ability against the killing effect of cyclophosphamide
Biochem. Pharmacol.
76
690-696
2008
Homo sapiens (P30838), Homo sapiens
Quash, G.; Fournet, G.; Courvoisier, C.; Martinez, R.M.; Chantepie, J.; Paret, M.J.; Pharaboz, J.; Joly-Pharaboz, M.O.; Gore, J.; Andre, J.; Reichert, U.
Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture
Eur. J. Med. Chem.
43
906-916
2008
Homo sapiens (P30838), Homo sapiens
Bajns J., Boulanger MJ.
Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400
J. Mol. Biol.
379
597-608
2008
Paraburkholderia xenovorans (Q13WK4), Paraburkholderia xenovorans LB400 (Q13WK4)
Szoecs, K.; Lassegue, B.; Wenzel, P.; Wendt, M.; Daiber, A.; Oelze, M.; Meinertz, T.; Muenzel, T.; Baldus, S.
Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation
J. Mol. Cell. Cardiol.
42
1111-1118
2007
Saccharomyces cerevisiae, Rattus norvegicus (P11884)
Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
Pharmacol. Rev.
59
125-150
2007
Homo sapiens (P30838), Homo sapiens (P43353), Homo sapiens (P47895)
Alnouti, Y.; Klaassen, C.D.
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice
Toxicol. Sci.
101
51-64
2008
Mus musculus (P47739), Mus musculus (Q80VQ0), Mus musculus (Q9JHW9)
Marchitti, S.A.; Brocker, C.; Stagos, D.; Vasiliou, V.
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Expert. Opin. Drug Metab. Toxicol.
4
697-720
2008
Homo sapiens
Gao, C.; Han, B.
Evolutionary and expression study of the aldehyde dehydrogenase (ALDH) gene superfamily in rice (Oryza sativa)
Gene
431
86-94
2009
Oryza sativa, Oryza sativa (Q0DZ46), Oryza sativa (Q53NG8), Oryza sativa (Q69P84), Oryza sativa (Q6H627), Oryza sativa (Q7XR89), Oryza sativa (Q9FRX7), Oryza sativa (Q9LRE9), Oryza sativa (Q9LRI6)
Koenig, U.; Amatschek, S.; Mildner, M.; Eckhart, L.; Tschachler, E.
Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes
Biochem. Biophys. Res. Commun.
400
207-211
2010
Homo sapiens (P47895)
Stagos, D.; Chen, Y.; Cantore, M.; Jester, J.V.; Vasiliou, V.
Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization
Brain Res. Bull.
81
211-218
2010
Mus musculus (Q9JHW9)
Liu, T.; Hao, L.; Wang, R.; Liu, B.
Molecular characterization of a thermostable aldehyde dehydrogenase (ALDH) from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7
Extremophiles
17
181-190
2013
Sulfurisphaera tokodaii (Q976X5), Sulfurisphaera tokodaii 7 (Q976X5)
Ngo, H.P.; Hong, S.H.; Oh, D.K.; Kang, L.W.
Expression, crystallization and preliminary X-ray crystallographic analysis of aldehyde dehydrogenase (ALDH) from Bacillus cereus
Acta Crystallogr. Sect. F
69
528-531
2013
Bacillus cereus (A0A150BLG9), Bacillus cereus ATCC 10876 (A0A150BLG9)
Zhou, S.; Catherine, C.; Rathnasingh, C.; Somasundar, A.; Park, S.
Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans
Biotechnol. Bioeng.
110
3177-3187
2013
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
Gonzalez-Segura, L.; Ho, K.K.; Perez-Miller, S.; Weiner, H.; Hurley, T.D.
Catalytic contribution of threonine 244 in human ALDH2
Chem. Biol. Interact.
202
32-40
2013
Homo sapiens
Zhou, M.L.; Zhang, Q.; Zhou, M.; Qi, L.P.; Yang, X.B.; Zhang, K.X.; Pang, J.F.; Zhu, X.M.; Shao, J.R.; Tang, Y.X.; Wu, Y.M.
Aldehyde dehydrogenase protein superfamily in maize
Funct. Integr. Genomics
12
683-691
2012
Zea mays
Lo, H.F.; Chen, Y.J.
Gene cloning and biochemical characterization of a NAD(P)+ -dependent aldehyde dehydrogenase from Bacillus licheniformis
Mol. Biotechnol.
46
157-167
2010
Bacillus licheniformis, Bacillus licheniformis ATCC 14580
Alam, M.F.; Laskar, A.A.; Choudhary, H.H.; Younus, H.
Human salivary aldehyde dehydrogenase: purification, kinetic characterization and effect of ethanol, hydrogen peroxide and sodium dodecyl sulfate on the activity of the enzyme
Cell Biochem. Biophys.
74
307-315
2016
Homo sapiens (P30838)
Hong, S.H.; Ngo, H.P.; Nam, H.K.; Kim, K.R.; Kang, L.W.; Oh, D.K.
Alternative biotransformation of retinal to retinoic acid or retinol by an aldehyde dehydrogenase from Bacillus cereus
Appl. Environ. Microbiol.
82
3940-3946
2016
Bacillus cereus (A0A150BLG9), Bacillus cereus, Bacillus cereus ATCC 10876 (A0A150BLG9)
Mali, V.R.; Deshpande, M.; Pan, G.; Thandavarayan, R.A.; Palaniyandi, S.S.
Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes
Cell. Signal.
28
1-6
2016
Rattus norvegicus
Gonzalez-Segura, L.; Riveros-Rosas, H.; Julian-Sanchez, A.; Munoz-Clares, R.A.
Residues that influence coenzyme preference in the aldehyde dehydrogenases
Chem. Biol. Interact.
234
59-74
2015
Sulfurisphaera tokodaii (Q976X5), Sulfurisphaera tokodaii DSM 16993 (Q976X5)
Tomita, H.; Tanaka, K.; Tanaka, T.; Hara, A.
Aldehyde dehydrogenase 1A1 in stem cells and cancer
Oncotarget
7
11018-11032
2016
Homo sapiens
Jimenez-Lopez, J.
Narrow-leafed lupin (Lupinus angustifolius L.) functional identification and characterization of the aldehyde dehydrogenase (ALDH) gene superfamily
Plant Gene
6
67-76
2016
Lupinus angustifolius
-
Aquino Neto, S.; Forti, J.; Zucolotto, V.; Ciancaglini, P.; de Andrade, A.
Development of nanostructured bioanodes containing dendrimers and dehydrogenases enzymes for application in ethanol biofuel cells
Biosens. Bioelectron.
26
2922-2926
2011
Saccharomyces cerevisiae
Zhang, Y.; Wang, M.; Lin, H.
A regulatory cysteine residue mediates reversible inactivation of NAD+-dependent aldehyde dehydrogenases to promote oxidative stress response
ACS Chem. Biol.
15
28-32
2020
Saccharomyces cerevisiae (P46367), Saccharomyces cerevisiae ATCC 204508 (P46367)
Ma, Z.; Jiang, L.; Li, G.; Liang, D.; Li, L.; Liu, L.; Jiang, C.
Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity
Bioorg. Chem.
101
103971
2020
Homo sapiens (P30838)
Kolawole, A.N.; Akinladejo, V.T.; Elekofehinti, O.O.; Akinmoladun, A.C.; Kolawole, A.O.
Experimental and computational modeling of interaction of kolaviron-kolaflavanone with aldehyde dehydrogenase
Bioorg. Chem.
78
68-79
2018
Saccharomyces cerevisiae
Jung, K.; Hong, S.H.; Ngo, H.P.; Ho, T.H.; Ahn, Y.J.; Oh, D.K.; Kang, L.W.
Crystal structures of an atypical aldehyde dehydrogenase having bidirectional oxidizing and reducing activities
Int. J. Biol. Macromol.
105
816-824
2017
Bacillus cereus (A0A150BLG9), Bacillus cereus
Buchman, C.D.; Hurley, T.D.
Inhibition of the aldehyde dehydrogenase 1/2 family by psoralen and coumarin derivatives
J. Med. Chem.
60
2439-2455
2017
Homo sapiens (P30838)
Wang, B.; Chen, X.; Wang, Z.; Xiong, W.; Xu, T.; Zhao, X.; Cao, Y.; Guo, Y.; Li, L.; Chen, S.; Huang, S.; Wang, X.; Fang, M.; Shen, Z.
Aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD+ reduction
Oncotarget
8
67043-67055
2017
Homo sapiens (P30838)
html completed
