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1.2.1.48: long-chain-aldehyde dehydrogenase

This is an abbreviated version!
For detailed information about long-chain-aldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.48

Reaction

a long-chain aldehyde
+
NAD+
 +
H2O
=
a long-chain carboxylate
 +
NADH
 +
H+

Synonyms

ALDH, ALDH10, ALDH3A2, Aldh3b1, ALDH3B2, ALDH3B3, Bt-Aldh, dehydrogenase, long-chain aliphatic aldehyde, FAldDH, FALDH, fatty aldehyde dehydrogenase, fatty aldehyde:NAD+ oxidoreductase, long-chain aldehyde dehydrogenase, long-chain fatty aldehyde dehydrogenase, long-chain-aldehyde dehydrogenase, membrane-bound fatty aldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.48 long-chain-aldehyde dehydrogenase

Inhibitors

Inhibitors on EC 1.2.1.48 - long-chain-aldehyde dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ag+
-
1 mM causes complete inhibition
alpha,p-dibromoacetophenone
-
0.03 mM causes 100% inhibition
Chloral hydrate
-
25 mM causes 29% inhibition
Disulfiram
-
0.065 mM causes 100% inhibition
EDTA
2 mM, 63% residual activity; 63% relative activity
Fe3+
-
1 mM causes complete inhibition
Hg2+
-
1 mM causes complete inhibition
iodoacetamide
-
10 mM causes 96% inhibition
iodoacetate
Mg2+
14% relative activity with 2 mM MgCl2 compared to the activity without metal ions; 2 mM, 14% residual activity
Mn2+
-
1 mM causes 37% inhibition
N-ethylmaleimide
p-chloromercuribenzoate
p-hydroxyacetophenone
-
0.25 mM causes 46% inhibition
Pb2+
-
1 mM causes complete inhibition
potassium cyanide
-
1 mM causes 33% inhibition
Triton X-100
-
at a final concentration of 0.01%