1.2.1.3: aldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALD6, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 16, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 1B1, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde dehydrogenase 6, aldehyde dehydrogenase 7A1, aldehyde dehydrogenase class 1, aldehyde dehydrogenase type 2, Aldehyde dehydrogenase [NAD+], Aldehyde dehydrogenase, cytosolic, Aldehyde dehydrogenase, microsomal, aldehyde dehydrogenase-2, aldehyde dehydrogenase7, aldehyde:NAD+ oxidoreductase, ALDH, ALDH 2, ALDH I, ALDH II, ALDH-2, ALDH-E1, ALDH-E2, ALDH1, ALDH1-NL, ALDH16, ALDH1A1, Aldh1a2, Aldh1a3, Aldh1a7, Aldh1b1, ALDH2, ALDH2(1), ALDH2(2), ALDH2(3), ALDH22A1, ALDH2B8, ALDH2C4, ALDH3A1, ALDH3A2, Aldh3b1, ALDH3H1, ALDH3I1, ALDH5A, ALDH7, Aldh7a1, ALDH7B4, Aldh8a1, ALDHI, ALDHTt, ALDHX, ALHDII, Allergen Alt a 10, aryl-aldehyde dehydrogenases, BADH, benzaldehyde dehydrogenase, Brassica turgor-responsive/drought-induced gene 26 protein, Bt-Aldh, Btg-26, class 1 aldehyde dehydrogenase, class 2 aldehyde dehydrogenase, class I ALDH, CoA-independent aldehyde dehydrogenase, coniferyl-aldehyde dehydrogenase, Cphy_1178, EC 1.1.1.70, ETA-crystallin, FeaB-K-12, gamma-aminobutyraldehyde dehydrogenase, hALDH2, HsALDH16A1, irreversible NAD+-dependent aldehyde dehydrogenase, K(+)-ACDH, K(+)-activated acetaldehyde dehydrogenase, KGSADH, LsALDH16, m-methylbenzaldehyde dehydrogenase, Matured fruit 60 kDa protein, MF-60, Mg(2+)-ACDH, Mg(2+)-activated acetaldehyde dehydrogenase, mitochondrial aldehyde dehydrogenase, More, NAD+-dependent aldehyde dehydrogenase, NAD+-dependent ALDH, NAD+-linked aldehyde dehydrogenase, NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase, NAD+-specific ALDH, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, Non-lens ALDH1, p-ALDH2, P51, phenylacetaldehyde dehydrogenase, PhnN, phnY, phosphonoacetaldehyde dehydrogenase, phosphonoacetaldehyde oxidase, PM-ALDH9, PnAA dehydrogenase, propionaldehyde dehydrogenase, PuuC, R-aminobutyraldehyde dehydrogenase, RALDH, RALDH(II), RalDH1, Retinal dehydrogenase, retinal dehydrogenase type I, sALDH, salvery aldehyde dehydrogenase, ThnG, TTC0513, Turgor-responsive protein 26G, yALDH, YneI

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.3 aldehyde dehydrogenase (NAD+)

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Results	in table
40	Activating Compound
20819	AA Sequence
16	Application
1	CAS Registry Number
70	Cloned(Commentary)
187	Cofactor
13	Crystallization (Commentary)
10146	Disease/ Diagnostics
16	Expression
43	General Information
6	General Stability
32	IC50 Value
286	Inhibitors
58	kcat/KM [mM/s]
29	Ki Value [mM]
553	KM Value [mM]
106	Localization
36	Metals/Ions
118	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
11	Organic Solvent Stability
261	Organism
1	Oxidation Stability
53	Pathway
513	PDB ID
49	pH Optimum
12	pH Range
13	pH Stability
8	pI Value
2	Posttranslational Modification
92	Protein Variants
86	Purification (Commentary)
7	Reaction
26	Reaction Type
213	Reference
235	Source Tissue
112	Specific Activity [micromol/min/mg]
12	Storage Stability
674	Substrates and Products (Substrate)
80	Subunits
331	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
3	Temperature Range [°C]
26	Temperature Stability [°C]
174	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2E)-4-hydroxy-2-nonenal + NAD+ + H2O

(2E)-4-hydroxy-2-nonenoic acid + NADH + H+

2 entries

(E)-2-nonenal + NAD+ + H2O

(E)-non-2-enoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxamide + H2O + O2

?

Homo sapiens

P05091

i.e. GDC-0834, a Bruton's tyrosine kinase inhibitor, a potential treatment of rheumatoid arthritis. GDC-0834

740355

compound is extensively metabolized by amide hydrolysis by both aldehyde oxidase and carboxylesterase

-

?

(R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O

(2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+

2 entries

(S)-trans-4-hydroxy-2-nonenal + NAD+ + H2O

(2E,4S)-4-hydroxynon-2-enoic acid + NADH + H+

Rattus norvegicus

P11884, P51650

-

691775

-

-

?

1,3-dihydroxyacetone + NAD+ + H2O

? + NADH + H+

Sulfurisphaera tokodaii

-

53.93% activity compared to acetaldehyde

722210

-

-

?

1-formyl-6-methylpyrene + NAD+

6-methylpyrene 1-carboxylate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

1-formyl-6-methylpyrene + NAD+ + H2O

6-methylpyrene-1-carboxylic acid + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

1-formyl-8-methylpyrene + NAD+ + H2O

8-methylpyrene-1-carboxylic acid + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

1-formyl-8-methylpyrene + NADP+

8-methylpyrene 1-carboxylate + NADPH + H+

Homo sapiens

P05091

-

684721

-

-

?

1-formylpyrene + NAD+

pyrene 1-carboxylate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

1-formylpyrene + NAD+ + H2O

pyrene-1-carboxylic acid + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

1-naphthaldehyde + NAD+ + H2O

1-naphthoic acid + NADH

Sphingomonas sp.

Q402C7

46.9% activity compared to p-tolualdehyde

671512

-

-

?

1-naphthaldehyde + NAD+ + H2O

1-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

2,4-dinitrobenzaldehyde + NAD+ + H2O

2,4-dinitrobenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

2-chlorobenzaldehyde + NAD+ + H2O

2-chlorobenzoate + NADH + H+

Geobacillus thermodenitrificans

-

28.35% activity compared to formaldehyde

712957

-

-

?

2-formylpyrene + NAD+

pyrene 2-carboxylate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

2-formylpyrene + NAD+ + H2O

pyrene-2-carboxylic acid + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

2-furaldehyde + NAD+ + H2O

2-furanoic acid + NADH + H+

2 entries

2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O

2-hydroxy-3-nitrobenzoic acid + NADH + H+

2 entries

2-naphthaldehyde + NAD+ + H2O

2-naphthalene carboxylate + NADH + H+

Homo sapiens

-

-

695926

-

-

?

2-naphthaldehyde + NAD+ + H2O

2-naphthoate + NADH

Homo sapiens

-

-

348694

-

-

?

2-naphthaldehyde + NAD+ + H2O

2-naphthoic acid + NADH

Sphingomonas sp.

Q402C7

48.8% activity compared to p-tolualdehyde

671512

-

-

?

2-naphthaldehyde + NAD+ + H2O

2-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

2-nonenal + NAD+ + H2O

(E)-non-2-enoate + NADH + H+

Homo sapiens

-

-

712435

-

-

?

2-phthalaldehyde + NAD+ + H2O

phthalate + NADH + H+

Geobacillus thermodenitrificans

-

10.81% activity compared to formaldehyde

712957

-

-

?

2-quinolinone-4-carboxaldehyde + NAD+ + H2O

2-quinolinone-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

3,4,5-trimethoxybenzaldehyde + NAD+ + H2O

3,4,5-trimethoxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

3,4-dihydroxybenzaldehyde + NAD+ + H2O

3,4-dihydroxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

3,4-dihydroxymandelic aldehyde + NAD+ + H2O

3,4-dihydroxymandelate + NADH

Rattus norvegicus

-

-

348715

-

-

?

3,4-dihydroxyphenyl acetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetate + NADH

Rattus norvegicus

-

-

348715

-

-

?

3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetate + NADH + H+

4 entries

3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetic acid + NADH + H+

Rattus norvegicus

-

-

740883

-

-

?

3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O

3,4-dihydroxyphenylglycolate + NADH + H+

Homo sapiens

P05091, P30837, Q9H2A2

-

689379

-

-

?

3,4-dimethoxy-5-hydroxybenzaldehyde + NAD+ + H2O

3,4-dimethoxy-5-hydroxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

3,4-dimethoxybenzaldehyde + NAD+ + H2O

3,4-dimethoxybenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

3,4-dimethoxybenzaldehyde + NAD+ + H2O

3,4-dimethoxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

3-hydroxy-4-methoxybenzaldehyde + NAD+ + H2O

3-hydroxy-4-methoxybenzoate + NADH + H+

Cavia porcellus

-

-

676317

-

-

?

3-hydroxypropaldehyde + NAD+ + H2O

3-hydroxypropionate + NADH + H+

Klebsiella pneumoniae

-

-

724645

-

-

?

3-hydroxypropanal + NAD+ + H2O

3-hydroxypropionate + NADH + H+

2 entries

3-hydroxypropanoate + NADH + 2 H+

3-hydroxypropionaldehyde + NAD+ + H2O

Escherichia coli

-

-

690591

-

-

r

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropanoate + NADH + 2 H+

2 entries

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

6 entries

3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O

3-methoxy-4-hydroxyphenylacetate + NADH + H+

Ovis aries

-

-

348699

-

-

?

3-nitrobenzaldehyde + NAD+ + H2O

3-nitrobenzoate + NADH + H+

Sulfurisphaera tokodaii

-

32.98% activity compared to acetaldehyde

722210

-

-

?

3-oxopropyl phosphonate + NAD+ + H2O

?

Sinorhizobium meliloti

Q92UV7

-

743680

-

-

?

3-oxopropylphosphonate + NAD+ + H2O

?

Sinorhizobium meliloti

Q92UV7

-

729577

-

-

?

3-pyridinecarboxaldehyde + NAD+ + H2O

3-pyridinecarboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

4-aminobutyraldehyde + NAD+ + H2O

4-aminobutyrate + NADH

Homo sapiens

-

-

348692, 348693, 348701

-

-

?

4-carboxybenzaldehyde + NAD+ + H2O

4-carboxybenzoate + NADH

Rattus norvegicus

-

-

348717

-

-

?

4-chlorobenzaldehyde + NAD+ + H2O

4-chlorobenzoate + NADH

Rattus norvegicus

-

-

348717

-

-

?

4-chlorophenylacetaldehyde + NAD+ + H2O

4-chlorophenylacetate + NADH + H+

Escherichia coli

-

-

739888

-

-

?

4-cyanobenzaldehyde + NAD+ + H2O

4-cyanobenzoate + NADH

Rattus norvegicus

-

-

348682

-

-

?

4-dimethylamino-1-naphthaldehyde + NAD+ + H2O

4-dimethylamino-1-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

4-dimethylaminobenzaldehyde + NAD+ + H2O

4-dimethylaminobenzoate + NADH + H+

Homo sapiens

-

-

700321

-

-

?

4-fluorophenylacetaldehyde + NAD+ + H2O

4-fluorophenylacetate + NADH + H+

Escherichia coli

-

-

739888

-

-

?

4-formylpyrene + NAD+

pyrene 4-carboxylate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

4-formylpyrene + NAD+ + H2O

pyrene-4-carboxylic acid + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxy-2-nonenoate + NADH + H+

2 entries

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxynon-2-enoate + NADH + H+

Oryctolagus cuniculus

-

-

711635

-

-

?

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxynon-2-enoic acid + NADH

2 entries

4-hydroxy-3,5-dimethoxybenzaldehyde + NAD+ + H2O

4-hydroxy-3,5-dimethoxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O

4-hydroxy-3-methoxybenzoate + NADH + H+

Homo sapiens

-

-

700321

-

-

?

4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O

4-hydroxy-3-methoxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

4-hydroxybenzaldehyde + NAD+ + H2O

4-hydroxybenzoic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

4-hydroxynon-2-enal + NAD+

4-hydroxynon-2-enoic acid + NADH

Homo sapiens

-

-

673059

-

-

?

4-hydroxynonenal + NAD+ + H2O

4-hydroxynonanoate + NADH

Oryctolagus cuniculus

-

-

655317

-

-

?

4-hydroxynonenal + NAD+ + H2O

4-hydroxynonanoate + NADH + H+

Homo sapiens

-

-

655317

-

-

?

4-hydroxynonenal + NAD+ + H2O

? + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O

4-hydroxyphenyl-3-methoxyglycolate + NADH

Sus scrofa

-

-

348704

-

-

?

4-hydroxyphenylglycolaldehyde + NAD+ + H2O

4-hydroxyphenylglycolate + NADH

Sus scrofa

-

-

348704

-

-

?

4-methoxy-1-naphthaldehyde + NAD+ + H2O

4-methoxy-1-naphthoate + NADH

Homo sapiens

-

-

348694

-

-

?

4-methoxy-1-naphthaldehyde + NAD+ + H2O

4-methoxy-1-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

4-methoxybenzaldehyde + NAD+ + H2O

4-methoxybenzoate + NADH + H+

Homo sapiens

-

-

700321

-

-

?

4-nitro-1-naphthaldehyde + NAD+ + H2O

4-nitro-1-naphthoate + NADH

Homo sapiens

-

-

348694

-

-

?

4-nitrophenyl acetate + H2O

4-nitrophenol + acetate

Bos taurus

-

-

348708

-

-

r

4-oxonon-2-enal + NAD+ + H2O

4-oxonon-2-enoic acid + NADH

Homo sapiens

-

-

673059

-

-

?

5-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O

5-(dimethylamino)-2-naphthoate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

5-bromo-1-naphthaldehyde + NAD+ + H2O

5-bromo-1-naphthoate + NADH

Homo sapiens

-

-

348694

-

-

?

5-hydroxyindol acetaldehyde + NAD+ + H2O

5-hydroxyindol acetate + NADH + H+

Rattus norvegicus

-

-

348715

-

-

?

5-methoxyindole-3-carboxaldehyde + NAD+ + H2O

5-methoxyindole-3-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

5-nitro-1-naphthaldehyde + NAD+ + H2O

5-nitro-1-naphthoate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

6,7-dimethoxycoumarin-3-carboxaldehyde + NAD+ + H2O

6,7-dimethoxycoumarin-3-carboxylate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

6,7-dimethoxycoumarin-4-carboxaldehyde + NAD+ + H2O

6,7-dimethoxycoumarin-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

6-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O

6-(dimethylamino)-2-naphthoate + NADH

Homo sapiens

-

-

348694

-

-

?

6-dimethylamino-2-naphthaldehyde + NAD+ + H2O

6-dimethylamino-2-naphthalene carboxylate + NADH + H+

Homo sapiens

-

activity assay

695926

-

-

?

6-dimethylamino-2-naphthaldehyde + NAD+ + H2O

6-dimethylamino-2-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

6-methoxy-2-naphthaldehyde + NAD+ + H2O

6-methoxy-2-naphthalene carboxylate + NADH + H+

Homo sapiens

-

activity assay

695926

-

-

?

6-methoxy-2-naphthaldehyde + NAD+ + H2O

6-methoxy-2-naphthoate + NADH + H+

2 entries

6-methoxy-2-naphthaldehyde + NAD+ + H2O

6-methoxy-2-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

6-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O

6-methoxy-2-quinolinone-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

7-(dimethylamino)-2-quinolinone-4-carboxaldehyde + NAD+ + H2O

7-(dimethylamino)-2-quinolinone-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

7-(dimethylamino)-coumarin-3-carboxaldehyde + NAD+ + H2O

7-(dimethylamino)-coumarin-3-carboxylate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

7-(dimethylamino)coumarin-4-carboxaldehyde + NAD+ + H2O

7-(dimethylamino)coumarin-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

7-acetoxycoumarin-3-carboxaldehyde + NAD+ + H2O

7-acetoxycoumarin-3-carboxylate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

7-acetoxycoumarin-4-carboxaldehyde + NAD+ + H2O

7-acetoxycoumarin-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

7-hydroxycoumarin-3-carboxaldehyde + NAD+ + H2O

7-hydroxycoumarin-3-carboxylate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

7-hydroxycoumarin-4-carboxaldehyde + NAD+ + H2O

7-hydroxycoumarin-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

7-methoxy-1-naphthaldehyde + NAD+ + H2O

7-methoxy-1-naphthoic acid + NADH + H+

3 entries

7-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O

7-methoxy-2-quinolinone-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

7-methoxycoumarin-3-carboxaldehyde + NAD+ + H2O

7-methoxycoumarin-3-carboxylate + NADH + H+

Homo sapiens

-

-

348694

-

-

r

7-methoxycoumarin-4-carboxaldehyde + NAD+ + H2O

7-methoxycoumarin-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

9-cis retinal + NAD+ + H2O

9-cis retinoic acid + NADH

Homo sapiens

-

-

691044

-

-

?

9-cis-retinal + NAD+ + H2O

9-cis-retinoic acid + NADH + H+

Homo sapiens

-

-

691867

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

54 entries

acetaldehyde + NADP+ + H2O

acetate + NADPH + H+

Sulfurisphaera tokodaii

-

low activity with NADP+

722210

-

-

?

acetate + NADH + H+

acetaldehyde + NAD+ + H2O

4 entries

acrolein + NAD+ + H2O

? + NADH + H+

Homo sapiens

-

-

726464

-

-

?

aldophosphamide + NAD+ + H2O

? + NADH + H+

Homo sapiens

-

-

691867

-

-

?

all-trans retinal + NAD+ + H2O

all-trans retinoic acid + NADH

Homo sapiens

-

-

691044

-

-

?

all-trans-retinal + NAD+ + H2O

all-trans-retinoic acid + NADH + H+

Homo sapiens

-

-

691867, 741427

-

-

?

alpha-aminoadipate semialdehyde + NAD+ + H2O

alpha-aminoadipate + NADH + H+

2 entries

alpha-aminoadipate semialdehyde + NAD+ + H2O

alpha-aminoadipic acid + NADH + H+

Homo sapiens

-

-

712435

-

-

?

alpha-phenylpropanal + NAD+ + H2O

alpha-phenylpropionate + NADH

Homo sapiens

-

-

348694

-

-

?

an aldehyde + NAD+ + H2O

an acid + NADH + H+

Homo sapiens

-

-

696996, 697280, 697845

-

-

?

anisaldehyde + NAD+ + H2O

? + NADH

Rattus norvegicus

-

-

348717

-

-

?

benzaldehyde + NAD(P)+ + H2O

benzoate + NAD(P)H + H+

Pseudomonas putida

-

-

680440

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

27 entries

benzaldehyde + NADP+

benzoate + NADPH

Rattus norvegicus

-

-

348791

-

-

?

benzaldehyde + NADP+ + H2O

benzoate + NADPH + H+

Escherichia coli

-

-

690591

-

-

?

betaine aldehyde + NAD+ + H2O

betaine + NADH

Homo sapiens

-

-

348692, 348693

-

-

?

betaine aldehyde + NAD+ + H2O

betaine + NADH + H+

Homo sapiens

-

-

712435

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

8 entries

butyraldehyde + NAD+ + H2O

butanoate + NADH + H+

Klebsiella pneumoniae

-

the activity on butyraldehyde is about 95% of that on valeraldehyde

711536

-

-

?

butyraldehyde + NAD+ + H2O

butanoic acid + NADH + H+

Escherichia coli

-

-

690591

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

7 entries

chloral + NAD+ + H2O

trichloroacetate + NADH + H+

Sulfurisphaera tokodaii

-

2.67% activity compared to acetaldehyde

722210

-

-

?

chloroacetaldehyde + NAD+ + H2O

chloroacetate + NADH + H+

4 entries

cinnamaldehyde + NAD+ + H2O

cinnamate + NADH + H+

2 entries

cinnamic aldehyde + NAD+ + H2O

cinnamic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

citral + NAD+ + H2O

(2E)-3,7-dimethylocta-2,6-dienoic acid + NADH

Ipomoea batatas

-

-

348722

-

-

?

crotonaldehyde + NAD+ + H2O

crotonate + NADH

Rattus norvegicus

-

-

348682

-

-

?

cyclohexanaldehyde + NAD+ + H2O

cyclohexanoate + NADH

Sus scrofa

-

-

348704

-

-

?

D-glucose + NAD+ + H2O

D-glucuronic acid + NADH

Ovis aries

-

-

348712

-

-

?

D-glyceraldehyde + NAD+ + H2O

D-glycerate + NADH + H+

2 entries

dansyl-aminoacetaldehyde + ?

dansylglycine + ?

Homo sapiens

-

the fluorescent substrate is used to monitor aldehyde dehydrogenase activity in fluorescence-activated cell sorting

672780, 672818

-

-

?

decanal + NAD+ + H2O

decanaote + NADH

Escherichia coli

P76217

-

655643

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

7 entries

decanaldehyde + NAD+ + H2O

decanoate + NADH + H+

Geobacillus thermodenitrificans

-

50.3% activity compared to formaldehyde

712957

-

-

?

DL-glyceraldehyde + NAD+ + H2O

DL-glycerate + NADH + H+

2 entries

DL-glyceraldehyde 3-phosphate + NAD+ + H2O

DL-glycerate 3-phosphate + NADH + H+

Sulfurisphaera tokodaii

-

52.7% activity compared to acetaldehyde

722210

-

-

?

dodecanal + NAD+ + H2O

dodecanoate + NADH

Oryctolagus cuniculus

-

n-dodecylaldehyde

348706

-

-

?

dodecanal + NAD+ + H2O

dodecanoate + NADH + H+

2 entries

dodecanaldehyde + NAD+ + H2O

dodecanoate + NADH + H+

Geobacillus thermodenitrificans

-

42.02% activity compared to formaldehyde

712957

-

-

?

eicosanoic aldehyde + NAD+ + H2O

eicosanoate + NADH + H+

Geobacillus thermodenitrificans

-

8.79% activity compared to formaldehyde

712957

-

-

?

fluorene-2-carboxaldehyde + NAD+ + H2O

fluorene-2-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

formaldehyde + NAD+

formate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

9 entries

formaldehyde + NAD+ + H2O

formate + NADH + H+

6 entries

glutaraldehyde + NAD+ + H2O

glutarate + NADH

Rattus norvegicus

-

-

348695, 348715

-

-

?

glutathione-4-oxonon-2-enal + NAD+ + H2O

glutathione-4-oxonon-2-enoic acid + NADH

Homo sapiens

-

-

673059

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH

4 entries

glyceraldehyde + NAD+ + H2O

glycerate + NADH + H+

2 entries

glyceraldehyde 3-phosphate + NAD+ + H2O

?

Sinorhizobium meliloti

Q92UV7

-

743680

-

-

?

glyceraldehyde 3-phosphate + NAD+ + H2O

glycerate 3-phosphate + NADH

Bos taurus

-

-

348708

-

-

?

glyceraldehyde-3-phosphate + NAD+ + H2O

?

Sinorhizobium meliloti

Q92UV7

-

729577

-

-

?

glyceryl trinitrate + NADH + H+

1,2-glyceryl dinitrate + nitrite + NAD+

Homo sapiens

-

-

697845, 698765

-

-

?

glyceryl trinitrate + NADH + H+

1,3-glyceryl dinitrate + nitrite + NAD+

Homo sapiens

-

-

698765

-

-

?

glycolaldehyde + NAD+ + H2O

glycolate + NADH

4 entries

glycolaldehyde + NAD+ + H2O

glycolate + NADH + H+

Sulfurisphaera tokodaii

-

75.43% activity compared to acetaldehyde

722210

-

-

?

glyoxal + NAD+ + H2O

oxalate + NADH

Rattus norvegicus

-

-

348682

-

-

?

heptanal + NAD+ + H2O

heptanoate + NADH

3 entries

hexadecanal + NAD+ + H2O

hexadecanoate + NADH + H+

Geobacillus thermodenitrificans

-

15.77% activity compared to formaldehyde

712957

-

-

?

hexaldehyde + NAD+ + H2O

hexanoate + NADH + H+

Geobacillus thermodenitrificans

-

76.21% activity compared to formaldehyde

712957

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

15 entries

hexanaldehyde + NAD+ + H2O

hexanoate + NADH + H+

Lachnoclostridium phytofermentans

A9KN57

-

741416

-

-

?

hydrocinnamaldehyde + NAD+ + H2O

hydrocinnamate + NADH

Homo sapiens

-

-

348694

-

-

?

indole-3-acetaldehyde + NAD+ + H2O

indole-3-acetate + NADH + H+

2 entries

indole-3-aldehyde + NAD+ + H2O

indole-3-carboxylate + NADH

2 entries

isobutanal + NAD+ + H2O

isobutyrate + NADH

Rattus norvegicus

-

-

348682, 348707

-

-

?

isovaleraldehyde + NAD+ + H2O

isovalerate + NADH + H+

2 entries

m-chlorobenzaldehyde + NAD+ + H2O

m-chlorobenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

44.7% activity compared to p-tolualdehyde

671512

-

-

?

m-fluorobenzaldehyde + NAD+ + H2O

m-fluorobenzoic acid + NADH + H+

2 entries

m-hydroxybenzaldehyde + NAD+ + H2O

m-hydroxybenzoate + NADH + H+

Homo sapiens

-

-

348694

-

-

?

m-hydroxybenzaldehyde + NAD+ + H2O

m-hydroxybenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

23.6% activity compared to p-tolualdehyde

671512

-

-

?

m-methoxybenzaldehyde + NAD+ + H2O

m-methoxybenzoate + NADH + H+

2 entries

m-methoxybenzaldehyde + NAD+ + H2O

m-methoxybenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

88.5% activity compared to p-tolualdehyde

671512

-

-

?

m-methylbenzaldehyde + NAD+ + H2O

m-methylbenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

m-nitrobenzaldehyde + NAD+ + H2O

m-nitrobenzoate + NADH

2 entries

m-nitrobenzaldehyde + NAD+ + H2O

m-nitrobenzoic acid + NADH

Sphingomonas sp.

Q402C7

46.8% activity compared to p-tolualdehyde

671512

-

-

?

m-tolualdehyde + NAD+ + H2O

m-methylbenzoic acid + NADH

Sphingomonas sp.

Q402C7

70.8% activity compared to p-tolualdehyde

671512

-

-

?

malondialdehyde + NAD+ + H2O

?

4 entries

malondialdehyde + NAD+ + H2O

? + NADH

3 entries

malondialdehyde + NAD+ + H2O

? + NADH + H+

Homo sapiens

-

-

726464

-

-

?

methylglyoxal + NAD+ + H2O

methylglyoxalate + NADH

Homo sapiens

-

-

348693

-

-

?

monochloroacetaldehyde + NAD+ + H2O

monochloroacetate + NADH

Rattus norvegicus

-

-

348682

-

-

?

N-acetyl-4-aminobutyraldehyde + NAD+ + H2O

N-acetyl-4-aminobutyrate + NADH

Homo sapiens

-

-

348692

-

-

?

n-nonanal + NAD+ + H2O

n-nonanoate + NADH + H+

3 entries

nitroglycerin + NAD+ + H2O

1,2-glyceryl dinitrate + NO + NADH + H+

Homo sapiens

-

-

712497

-

-

?

nonanal + NAD+ + H2O

nonanoate + NADH + H+

2 entries

o-chlorobenzaldehyde + NAD+ + H2O

o-chlorobenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

3.4% activity compared to p-tolualdehyde

671512

-

-

?

o-fluorobenzaldehyde + NAD+ + H2O

o-fluorobenzoic acid + NADH + H+

2 entries

o-hydroxybenzaldehyde + NAD+ + H2O

o-hydroxybenzoate + NADH + H+

Homo sapiens

-

-

348694

-

-

?

o-hydroxybenzaldehyde + NAD+ + H2O

o-hydroxybenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

65.2% activity compared to p-tolualdehyde

671512

-

-

?

o-methoxybenzaldehyde + NAD+ + H2O

o-methoxybenzoate + NADH + H+

Homo sapiens

-

-

348694

-

-

?

o-methoxybenzaldehyde + NAD+ + H2O

o-methoxybenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

2.6% activity compared to p-tolualdehyde

671512

-

-

?

o-methylbenzaldehyde + NAD+ + H2O

o-methylbenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

o-nitrobenzaldehyde + NAD+ + H2O

o-nitrobenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

o-nitrobenzaldehyde + NAD+ + H2O

o-nitrobenzoic acid + NADH

Sphingomonas sp.

Q402C7

17.8% activity compared to p-tolualdehyde

671512

-

-

?

o-tolualdehyde + NAD+ + H2O

o-methylbenzoic acid + NADH

Sphingomonas sp.

Q402C7

3.7% activity compared to p-tolualdehyde

671512

-

-

?

octadecanal + NAD+ + H2O

octadecanoate + NADH + H+

Geobacillus thermodenitrificans

-

12% activity compared to formaldehyde

712957

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

6 entries

octanal + NAD+ + H2O

octanoate + NADH + H+

2 entries

octyl aldehyde + NAD+ + H2O

octanoate + NADH + H+

Geobacillus thermodenitrificans

-

72.27% activity compared to formaldehyde

712957

-

-

?

p-(dimethylamino)-benzaldehyde + NAD+ + H2O

p-(dimethylamino)benzoate + NADH

Homo sapiens

-

-

348694

-

-

?

p-(dimethylamino)cinnamaldehyde + NAD+ + H2O

p-(dimethylamino)cinnamate + NADH

2 entries

p-carboxybenzaldehyde + NAD+ + H2O

p-carboxybenzoate + NADH

Rattus norvegicus

-

-

348682

-

-

?

p-chlorobenzaldehyde + NAD+ + H2O

p-chlorobenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

79.6% activity compared to p-tolualdehyde

671512

-

-

?

p-fluorobenzaldehyde + NAD+ + H2O

p-fluorobenzoic acid + NADH + H+

2 entries

p-hydroxybenzaldehyde + NAD+ + H2O

p-hydroxybenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

4.2% activity compared to p-tolualdehyde

671512

-

-

?

p-hydroxyphenylacetaldehyde + NAD+ + H2O

p-hydroxyphenylacetate + NADH

2 entries

p-methoxybenzaldehyde + NAD+ + H2O

p-methoxybenzoate + NADH + H+

3 entries

p-methoxybenzaldehyde + NAD+ + H2O

p-methoxybenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

6.2% activity compared to p-tolualdehyde

671512

-

-

?

p-methylbenzaldehyde + NAD+ + H2O

p-methylbenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoate + NADH

5 entries

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoic acid + NADH

Sphingomonas sp.

Q402C7

69% activity compared to p-tolualdehyde

671512

-

-

?

p-nitrocinnamaldehyde + NAD+ + H2O

p-nitrocinnamate + NADH

Homo sapiens

-

-

348694

-

-

?

p-nitrophenyl acetate + H2O

p-nitrophenol + acetate

Rattus norvegicus

-

esterase activity of the various isoenzymes is less than 7% of the activity with propanal and NAD+

348791

-

-

?

p-tolualdehyde + NAD+ + H2O

p-methylbenzoic acid + NADH

Sphingomonas sp.

Q402C7

highest activity

671512

-

-

?

pentanal + NAD+ + H2O

pentanoate + NADH

3 entries

pentanaldehyde + NAD+ + H2O

pentanoate + NADH + H+

Lachnoclostridium phytofermentans

A9KN57

-

741416

-

-

?

phenanthrene-9-carboxaldehyde + NAD+ + H2O

phenanthrene-9-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

6 entries

phosphonoacetaldehyde + NAD+

?

Sinorhizobium meliloti

-

-

719938

-

-

?

phosphonoacetaldehyde + NAD+ + H2O

phosphonoacetate + NADH + H+

Sinorhizobium meliloti

Q92UV7

-

729577, 743680

-

-

?

pimelic semialdehyde + NAD+ + H2O

?

2 entries

pivaldehyde + NAD+ + H2O

pivalate + NADH

Sus scrofa

-

-

348704

-

-

?

propanal + 1,N6-ethenoadenine dinucleotide + H2O

propionate + ?

Homo sapiens

-

isoenzyme E3

348696

-

-

?

propanal + 3-acetylpyridine-adenine dinucleotide + H2O

propionate + ?

Homo sapiens

-

isoenzyme E3

348696

-

-

?

propanal + 3-acetylpyridine-NAD+ + H2O

propionate + 3-acetylpyridine-NADH

Rattus norvegicus

-

-

348682

-

-

?

propanal + 3-thionicotinamide-adenine dinucleotide + H2O

propionate + ?

Homo sapiens

-

isoenzyme E3

348696

-

-

?

propanal + deamino-NAD+ + H2O

propionate + deamino-NADH

Rattus norvegicus

-

-

348682

-

-

?

propanal + N-guanine dinucleotide + H2O

propionate + ?

Homo sapiens

-

isoenzyme E3

348696

-

-

?

propanal + NAD+ + H2O

propanoate + NADH + H+

5 entries

propanal + NAD+ + H2O

propanoic acid + NADH + H+

Homo sapiens

-

activity assay

697845

-

-

?

propanal + NAD+ + H2O

propionate + NADH

15 entries

propanal + NAD+ + H2O

propionate + NADH + H+

5 entries

propanal + oxidized nicotinamide hypoxanthine dinucleotide + H2O

propionate + reduced nicotinamide hypoxanthine dinucleotide

Homo sapiens

-

isoenzyme E3

348696

-

-

?

propanal + [5-(3-acetylpyridino)pentyl]diphosphoadenosine + H2O

propanoate + ?

Equus caballus

-

-

348697

-

-

?

propionaldehyde + NAD+

propionate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

propionaldehyde + NAD+ + H2O

propanoate + NADH + H+

4 entries

propionaldehyde + NAD+ + H2O

propanoic acid + NADH + H+

Escherichia coli

-

-

690591

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH

Homo sapiens

-

-

654655, 711740, 711836

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

13 entries

protocatechaldehyde + NAD+ + H2O

protocatechuic acid + NADH

Sphingomonas sp.

Q402C7

4.5% activity compared to p-tolualdehyde

671512

-

-

?

pyridine 3-aldehyde + NAD+ + H2O

pyridine-3-carboxylate + NADH

Sus scrofa

-

-

348704

-

-

?

pyridine-3-aldehyde adenine dinucleotide + NAD+ + H2O

pyridine-3-carboxylate adenine dinucleotide + NADH

Ovis aries

-

-

348712

-

-

?

pyruvic aldehyde + NAD+ + H2O

pyruvate + NADH

Rattus norvegicus

-

-

348682

-

-

?

quinoline-3-carboxaldehyde + NAD+ + H2O

quinoline-3-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

quinoline-4-carboxaldehyde + NAD+ + H2O

quinoline-4-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

retinal + NAD+ + H2O

retinoic acid + NADH + H+

Homo sapiens

P05091, P30837, Q9H2A2

-

689379

-

-

?

retinol + NAD+ + H2O

retinoic acid + NADH + H+

Oryzias latipes

-

-

711790

-

-

?

succinic semialdehyde + NAD+ + H2O

succinate + NADH

2 entries

syringaldehyde + NAD+ + H2O

syringic acid + NADH

Sphingomonas sp.

Q402C7

65.1% activity compared to p-tolualdehyde

671512

-

-

?

tetradecanal + NAD+ + H2O

tetradecanoate + NADH

2 entries

tetradecyl aldehyde + NAD+ + H2O

tetradecanoate + NADH + H+

Geobacillus thermodenitrificans

-

11.71% activity compared to formaldehyde

712957

-

-

?

trans-2-hexenal + NAD+ + H2O

(E)-hex-2-enoate + NADH + H+

2 entries

trans-2-nonenal + NAD+ + H2O

(E)-non-2-enoate + NADH + H+

Arabidopsis thaliana

Q70DU8

-

740105

-

-

?

trans-cinnamaldehyde + NAD+ + H2O

trans-cinnamate + NADH

2 entries

valeraldehyde + NAD+ + H2O

valerate + NADH + H+

3 entries

vanillin + NAD+ + H2O

vanillic acid + NADH + H+

2 entries

additional information

?

-

47 entries

(2E)-4-hydroxy-2-nonenal + NAD+ + H2O

(2E)-4-hydroxy-2-nonenoic acid + NADH + H+

Bos taurus

-

-

693311

-

-

?

(2E)-4-hydroxy-2-nonenal + NAD+ + H2O

(2E)-4-hydroxy-2-nonenoic acid + NADH + H+

Rattus norvegicus

-

-

693311

-

-

?

(R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O

(2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+

Rattus norvegicus

P11884, P51650

-

691775

-

-

?

(R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O

(2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+

Rattus norvegicus

P11884, P51650

ALDH5A enantioselectively oxidizes (R)-trans-4-hydroxy-2-nonenal

691775

-

-

?

2-furaldehyde + NAD+ + H2O

2-furanoic acid + NADH + H+

Escherichia coli

-

-

690591

-

-

?

2-furaldehyde + NAD+ + H2O

2-furanoic acid + NADH + H+

Klebsiella pneumoniae

-

the activity on 2-furaldehyde is 22% of that on 3-hydroxypropionaldehyde

711536

-

-

?

2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O

2-hydroxy-3-nitrobenzoic acid + NADH + H+

Homo sapiens

-

-

697280

-

-

?

2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O

2-hydroxy-3-nitrobenzoic acid + NADH + H+

Homo sapiens

P05091

-

692780

-

-

?

3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetate + NADH + H+

Homo sapiens

-

-

348705, 689379

-

-

?

3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetate + NADH + H+

Homo sapiens

P05091, P30837, Q9H2A2

-

689379

-

-

?

3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetate + NADH + H+

Ovis aries

-

-

348699

-

-

?

3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O

3,4-dihydroxyphenylacetate + NADH + H+

Rattus norvegicus

-

-

713089

-

-

?

3-hydroxypropanal + NAD+ + H2O

3-hydroxypropionate + NADH + H+

Klebsiella pneumoniae

-

-

748257

-

-

?

3-hydroxypropanal + NAD+ + H2O

3-hydroxypropionate + NADH + H+

Klebsiella pneumoniae DSM 2026

-

-

748257

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropanoate + NADH + 2 H+

Escherichia coli

-

-

690591

-

-

r

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropanoate + NADH + 2 H+

Klebsiella pneumoniae

-

the activity on 3-hydroxypropionaldehyde is about 70% of that on valeraldehyde

711536

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

Escherichia coli

-

-

762811

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

Klebsiella pneumoniae

-

-

763211

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

Klebsiella pneumoniae

A6T8Z5

specific substrate

740167

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

Klebsiella pneumoniae MCG 78578

A6T8Z5

specific substrate

740167

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

Klebsiella pneumoniae subsp. pneumoniae

A6T782

-

762856

-

-

?

3-hydroxypropionaldehyde + NAD+ + H2O

3-hydroxypropionic acid + NADH + H+

Klebsiella pneumoniae subsp. pneumoniae ATCC 700721

A6T782

-

762856

-

-

?

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxy-2-nonenoate + NADH + H+

Homo sapiens

-

low affinity for substrate binding and poor catalytic efficiency

711836

-

-

?

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxy-2-nonenoate + NADH + H+

Mus musculus

P47738

-

693766

-

-

?

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxynon-2-enoic acid + NADH

Mus musculus

P47738, Q3UNF5, Q9CZS1, Q9DBF1

-

711635

-

-

?

4-hydroxy-2-nonenal + NAD+ + H2O

4-hydroxynon-2-enoic acid + NADH

Mus musculus

P47738, Q3UNF5, Q9CZS1, Q9DBF1

poor substrate of isoform ALDH3A1

711635

-

-

?

6-methoxy-2-naphthaldehyde + NAD+ + H2O

6-methoxy-2-naphthoate + NADH + H+

Homo sapiens

-

-

689316, 697802

-

-

?

6-methoxy-2-naphthaldehyde + NAD+ + H2O

6-methoxy-2-naphthoate + NADH + H+

Homo sapiens

-

activity assay

686331, 697567, 697569

-

-

?

7-methoxy-1-naphthaldehyde + NAD+ + H2O

7-methoxy-1-naphthoic acid + NADH + H+

Bos taurus

-

-

693311

-

-

?

7-methoxy-1-naphthaldehyde + NAD+ + H2O

7-methoxy-1-naphthoic acid + NADH + H+

Homo sapiens

-

-

700321

-

-

?

7-methoxy-1-naphthaldehyde + NAD+ + H2O

7-methoxy-1-naphthoic acid + NADH + H+

Rattus norvegicus

-

-

693311

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Acanthopagrus schlegelii

-

-

655237

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Acetivibrio thermocellus

-

-

738540

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Acetivibrio thermocellus DSM 1313

-

-

738540

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Arabidopsis thaliana

-

-

711583, 724222

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Bacillus cereus

-

-

723877

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Bacillus cereus ATCC 10876

-

-

723877

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Bos taurus

-

-

348708, 348723

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Ctenopharyngodon idella

-

-

348687

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Culex quinquefasciatus

-

-

348684

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Danio rerio

-

-

673291

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Equus caballus

-

-

348718

-

-

ir

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Escherichia coli

-

-

690591

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Euglena gracilis

-

-

675118

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Geobacillus thermodenitrificans

-

77.68% activity compared to formaldehyde

712957

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Geobacillus thermodenitrificans NG80-2

-

77.68% activity compared to formaldehyde

712957

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

-

348688, 348690, 348692, 348693, 348694, 348705, 348710, 348720, 654424, 684721

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

-

686531, 689379

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

P05091, P30837, Q9H2A2

-

689379

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

-

691603, 691867, 691973, 692542, 692781, 693946, 694110, 710796, 711691, 711836, 712497, 741427

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

-

348718

-

-

ir

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

P05091

-

672038, 672209

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

-

672209

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

P05091

-

673291, 692988, 712375

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

preferred substrate

655948

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

-

activity assay

698765

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Homo sapiens

P05091, P30837, Q9H2A2

preferred substrate of isozyme ALDH2

689379

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Ipomoea batatas

-

-

348722

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Klebsiella pneumoniae

-

the activity on acetaldehyde is about 50% of that on valeraldehyde

711536

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Klebsiella pneumoniae DSM 2026

-

the activity on acetaldehyde is about 50% of that on valeraldehyde

711536

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Lachnoclostridium phytofermentans

A9KN57

-

741416

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Mus musculus

-

-

692281

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Mus musculus

O35945, P47738, P47740, Q8BH00, Q9CZS1

-

690142

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Natronomonas pharaonis

A0A1U7EWW7

-

736074

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Nocardia sp.

-

-

348679

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Nocardia sp. 239

-

-

348679

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Oryctolagus cuniculus

-

activity with cytosolic enzyme, no activity with microsomal enzyme

348706

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Oryza sativa

Q9FPK6

-

713308

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Oryzias latipes

-

-

711790

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Ovis aries

-

-

348699, 348704, 348712, 348713

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Ovis aries

-

-

348718

-

-

ir

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Pseudomonas aeruginosa

-

-

348681, 348689, 348725

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Pseudomonas aeruginosa IH 35342

-

-

348689

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Rattus norvegicus

-

-

348682, 348690, 348695, 348700, 348707, 348715, 348717, 348791, 692281, 692337, 692623, 695139, 711651

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Rattus norvegicus

P11884, P51650

-

691775

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Rattus norvegicus

-

mutations in Aldh2 strongly segregate with the phenotypes of low and high alcohol consumption and with kinetic differences in ALDH2, suggesting that pharmacogenetic differences affect voluntary alcohol consumption. Bases mutated in the coding region suggest that aldh2(2) in low drinkers is ancestral to the coding changes of either aldh2(1) or aldh2(3), which segregate with higher ethanol consumption

656901

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Rattus norvegicus

P11884

rats with an mutated allele for aldehyde dehydrogenase (ALDH2-2) show a low alcohol consumption phenotype. Homozygous ALDH2-2 rats derived from high-drinker F0 females showed a remarkly higher ethanol consumption than homozygous animals derived from low-drinker females. Mitochondria of F2 rats derived from high alcohol-consuming females were more active in oxidizing substrates that generate NADH for complex I

673505

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Saccharomyces cerevisiae

-

-

348724, 692623, 723973

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Saccharomyces cerevisiae

-

activity assay

698039

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Sulfurisphaera tokodaii

-

100% activity with acetaldehyde and NAD+

722210

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Sulfurisphaera tokodaii 7

-

100% activity with acetaldehyde and NAD+

722210

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Sus scrofa

-

-

348704

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Thermoanaerobacterium saccharolyticum

-

-

738540

-

-

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Thermoanaerobacterium saccharolyticum JW/SL-YS485

-

-

738540

-

-

?

acetate + NADH + H+

acetaldehyde + NAD+ + H2O

Acetivibrio thermocellus

-

-

738540

-

-

?

acetate + NADH + H+

acetaldehyde + NAD+ + H2O

Acetivibrio thermocellus DSM 1313

-

-

738540

-

-

?

acetate + NADH + H+

acetaldehyde + NAD+ + H2O

Thermoanaerobacterium saccharolyticum

-

-

738540

-

-

?

acetate + NADH + H+

acetaldehyde + NAD+ + H2O

Thermoanaerobacterium saccharolyticum JW/SL-YS485

-

-

738540

-

-

?

alpha-aminoadipate semialdehyde + NAD+ + H2O

alpha-aminoadipate + NADH + H+

Homo sapiens

-

-

744371

-

-

?

alpha-aminoadipate semialdehyde + NAD+ + H2O

alpha-aminoadipate + NADH + H+

Homo sapiens

P49419

-

740072

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Ctenopharyngodon idella

-

-

348687

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Culex quinquefasciatus

-

-

348684

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Euglena gracilis

-

-

675118

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Geobacillus thermodenitrificans

-

72.38% activity compared to formaldehyde

712957

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Geobacillus thermodenitrificans NG80-2

-

72.38% activity compared to formaldehyde

712957

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

-

-

348694, 684721

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

P05091

-

684721

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

-

-

700321, 711836

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

P05091

-

672038, 690896

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

-

-

690896

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

P05091

-

692780

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Homo sapiens

-

low affinity for benzaldehyde

712435

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Ipomoea batatas

-

-

348722

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Klebsiella pneumoniae

-

-

748257

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Klebsiella pneumoniae

-

the activity on benzaldehyde is 35% of that on 3-hydroxypropionaldehyde

711536

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Klebsiella pneumoniae DSM 2026

-

-

748257

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Klebsiella pneumoniae DSM 2026

-

the activity on benzaldehyde is 35% of that on 3-hydroxypropionaldehyde

711536

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Nocardia sp.

-

-

348679

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Nocardia sp. 239

-

-

348679

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Ovis aries

-

-

348712

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Phanerodontia chrysosporium

-

best substrate, isoform ALDH1 shows 2fold greater catalytic activity against benzaldehyde than against other substrates, while isoform ALDH2 shows no substrate preferences

711095

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Rattus norvegicus

-

-

348695, 348707, 348717, 348791, 677208

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Rattus norvegicus

-

promotion-associated enzyme, no activity with phenobarbital-inducible enzyme

348680

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Sphingomonas sp.

Q402C7

73.9% activity compared to p-tolualdehyde

671512

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Sphingomonas sp. 14DN-61

Q402C7

73.9% activity compared to p-tolualdehyde

671512

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Sulfurisphaera tokodaii

-

35.5% activity compared to acetaldehyde

722210

-

-

?

benzaldehyde + NAD+ + H2O

benzoate + NADH + H+

Sulfurisphaera tokodaii 7

-

35.5% activity compared to acetaldehyde

722210

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Oryctolagus cuniculus

-

n-butanal

348706

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Ovis aries

-

-

348699, 348704, 348711, 348712, 348713

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Pseudomonas aeruginosa

-

-

348681, 348725

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Rattus norvegicus

-

-

348682, 348695, 348707

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Rattus norvegicus

-

n-butanal

348717

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Rhodococcus erythropolis

Q4F895

-

671542

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Rhodococcus erythropolis UPV-1

Q4F895

-

671542

-

-

?

butanal + NAD+ + H2O

butyrate + NADH + H+

Sus scrofa

-

-

348704

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Geobacillus thermodenitrificans

-

71.65% activity compared to formaldehyde

712957

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Geobacillus thermodenitrificans NG80-2

-

71.65% activity compared to formaldehyde

712957

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Lachnoclostridium phytofermentans

A9KN57

-

741416

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Sulfurisphaera tokodaii

-

48.15% activity compared to acetaldehyde

722210

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Sulfurisphaera tokodaii 7

-

48.15% activity compared to acetaldehyde

722210

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Vitis labrusca

K9N4H5

-

741147

-

-

?

butyraldehyde + NAD+ + H2O

butyrate + NADH + H+

Vitis quinquangularis

K9N4H5

-

741147

-

-

?

chloroacetaldehyde + NAD+ + H2O

chloroacetate + NADH + H+

Homo sapiens

-

-

655948

-

-

?

chloroacetaldehyde + NAD+ + H2O

chloroacetate + NADH + H+

Homo sapiens

P05091

-

672209

-

-

?

chloroacetaldehyde + NAD+ + H2O

chloroacetate + NADH + H+

Homo sapiens

-

activity is twice as fast as with acetaldehyde, native enzyme and mutant enzyme E487K

348690

-

-

?

chloroacetaldehyde + NAD+ + H2O

chloroacetate + NADH + H+

Rattus norvegicus

-

activity is twice as fast as with acetaldehyde, native enzyme and mutant enzyme E487K

348690

-

-

?

cinnamaldehyde + NAD+ + H2O

cinnamate + NADH + H+

Sphingomonas sp.

Q402C7

15.5% activity compared to p-tolualdehyde

671512

-

-

?

cinnamaldehyde + NAD+ + H2O

cinnamate + NADH + H+

Sphingomonas sp. 14DN-61

Q402C7

15.5% activity compared to p-tolualdehyde

671512

-

-

?

D-glyceraldehyde + NAD+ + H2O

D-glycerate + NADH + H+

Rattus norvegicus

-

-

348707

-

-

r

D-glyceraldehyde + NAD+ + H2O

D-glycerate + NADH + H+

Sulfurisphaera tokodaii

-

50.25% activity compared to acetaldehyde

722210

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Homo sapiens

-

-

348694

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Ipomoea batatas

-

n-decylaldehyde

348722

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Oryctolagus cuniculus

-

n-decylaldehyde

348706

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Ovis aries

-

-

348699, 348704

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Pseudomonas aeruginosa

-

-

348681, 348725

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Rattus norvegicus

-

-

348691, 348716

-

-

?

decanal + NAD+ + H2O

decanoate + NADH

Sus scrofa

-

-

348704

-

-

?

DL-glyceraldehyde + NAD+ + H2O

DL-glycerate + NADH + H+

Sulfurisphaera tokodaii

-

77.27% activity compared to acetaldehyde

722210

-

-

?

DL-glyceraldehyde + NAD+ + H2O

DL-glycerate + NADH + H+

Sulfurisphaera tokodaii

-

low activity with NADP+

722210

-

-

?

dodecanal + NAD+ + H2O

dodecanoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

dodecanal + NAD+ + H2O

dodecanoate + NADH + H+

Arabidopsis thaliana

-

best substrate

724222

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Homo sapiens

-

activity with enzyme ALDH-2, no activity with enzyme ALDH-1

348694

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Nocardia sp.

-

-

348679

-

-

ir

formaldehyde + NAD+ + H2O

formate + NADH

Nocardia sp. 239

-

-

348679

-

-

ir

formaldehyde + NAD+ + H2O

formate + NADH

Oryctolagus cuniculus

-

activity with cytosolic enzyme, no activity with microsomal enzyme

348706

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Ovis aries

-

-

348712

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Rattus norvegicus

-

-

348682, 348695, 711651

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Rattus norvegicus

-

no activity

348717

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Rhodococcus erythropolis

Q4F895

-

671542

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH

Rhodococcus erythropolis UPV-1

Q4F895

-

671542

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH + H+

Geobacillus thermodenitrificans

-

100% activity

712957

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH + H+

Homo sapiens

-

-

712497, 713544, 684721

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH + H+

Homo sapiens

P05091

-

684721, 712375

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH + H+

Saccharomyces cerevisiae

P54115

-

763375

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH + H+

Saccharomyces cerevisiae ATCC 204508

P54115

-

763375

-

-

?

formaldehyde + NAD+ + H2O

formate + NADH + H+

Sulfurisphaera tokodaii

-

7.77% activity compared to acetaldehyde

722210

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH

Bos taurus

-

-

348708, 348723

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH

Homo sapiens

-

-

348683, 348721

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH

Ovis aries

-

-

348702

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH

Rattus norvegicus

-

-

348700, 348707

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH + H+

Homo sapiens

-

-

712435, 726464

-

-

?

glyceraldehyde + NAD+ + H2O

glycerate + NADH + H+

Oryza sativa

Q9FPK6

-

713308

-

-

?

glycolaldehyde + NAD+ + H2O

glycolate + NADH

Bos taurus

-

-

348708

-

-

?

glycolaldehyde + NAD+ + H2O

glycolate + NADH

Halobacterium salinarum

-

the aldehyde dehydrogenase is a halophilic enzyme with the highest activity at 1 M NaCl

675670

-

-

?

glycolaldehyde + NAD+ + H2O

glycolate + NADH

Homo sapiens

-

-

348683, 348692, 348693, 348705

-

-

?

glycolaldehyde + NAD+ + H2O

glycolate + NADH

Rattus norvegicus

-

-

348682, 348695

-

-

?

heptanal + NAD+ + H2O

heptanoate + NADH

Homo sapiens

-

-

348694

-

-

?

heptanal + NAD+ + H2O

heptanoate + NADH

Oryctolagus cuniculus

-

n-heptanal

348706

-

-

?

heptanal + NAD+ + H2O

heptanoate + NADH

Rattus norvegicus

-

-

348682

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Arabidopsis thaliana

Q70DU8

-

740105

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Homo sapiens

-

-

348694, 655317, 711836

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Homo sapiens

-

high specificity

712435

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Ipomoea batatas

-

n-hexanal

348722

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Loktanella sp.

-

-

763362

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Oryctolagus cuniculus

-

-

655317

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Oryctolagus cuniculus

-

n-hexanal

348706

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Pseudomonas aeruginosa

-

-

348681, 348725

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Rattus norvegicus

-

-

348695, 348707, 348717, 677208

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Rhodococcus erythropolis

Q4F895

-

671542

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Rhodococcus erythropolis UPV-1

Q4F895

-

671542

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Thermus thermophilus

Q72KD3

-

763724

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Thermus thermophilus ATCC BAA-163

Q72KD3

-

763724

-

-

?

hexanal + NAD+ + H2O

hexanoate + NADH + H+

Thermus thermophilus DSM 7039

Q72KD3

-

763724

-

-

?

indole-3-acetaldehyde + NAD+ + H2O

indole-3-acetate + NADH + H+

Homo sapiens

-

-

348694, 348705

-

-

?

indole-3-acetaldehyde + NAD+ + H2O

indole-3-acetate + NADH + H+

Ovis aries

-

-

348699

-

-

?

indole-3-aldehyde + NAD+ + H2O

indole-3-carboxylate + NADH

Homo sapiens

-

-

348694

-

-

?

indole-3-aldehyde + NAD+ + H2O

indole-3-carboxylate + NADH

Sus scrofa

-

-

348704

-

-

?

isovaleraldehyde + NAD+ + H2O

isovalerate + NADH + H+

Escherichia coli

-

-

690591

-

-

?

isovaleraldehyde + NAD+ + H2O

isovalerate + NADH + H+

Klebsiella pneumoniae

-

the activity on isovaleraldehyde is about 80% of that on valeraldehyde

711536

-

-

?

m-fluorobenzaldehyde + NAD+ + H2O

m-fluorobenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

52.6% activity compared to p-tolualdehyde

671512

-

-

?

m-fluorobenzaldehyde + NAD+ + H2O

m-fluorobenzoic acid + NADH + H+

Sphingomonas sp. 14DN-61

Q402C7

52.6% activity compared to p-tolualdehyde

671512

-

-

?

m-methoxybenzaldehyde + NAD+ + H2O

m-methoxybenzoate + NADH + H+

Homo sapiens

-

-

348694

-

-

?

m-methoxybenzaldehyde + NAD+ + H2O

m-methoxybenzoate + NADH + H+

Rattus norvegicus

-

-

348695

-

-

?

m-nitrobenzaldehyde + NAD+ + H2O

m-nitrobenzoate + NADH

Ovis aries

-

-

348712

-

-

?

m-nitrobenzaldehyde + NAD+ + H2O

m-nitrobenzoate + NADH

Rattus norvegicus

-

-

348717

-

-

?

malondialdehyde + NAD+ + H2O

?

Homo sapiens

-

low affinity for substrate binding and poor catalytic efficiency

711836

-

-

?

malondialdehyde + NAD+ + H2O

?

Mus musculus

P47738, Q3UNF5, Q9CZS1, Q9DBF1

-

711635

-

-

?

malondialdehyde + NAD+ + H2O

?

Oryctolagus cuniculus

-

poor substrate of isoform ALDH3A1

711635

-

-

?

malondialdehyde + NAD+ + H2O

?

Oryza sativa

Q9FPK6

-

713308

-

-

?

malondialdehyde + NAD+ + H2O

? + NADH

Bos taurus

-

-

348708

-

-

?

malondialdehyde + NAD+ + H2O

? + NADH

Homo sapiens

-

-

655317

-

-

?

malondialdehyde + NAD+ + H2O

? + NADH

Oryctolagus cuniculus

-

-

655317

-

-

?

n-nonanal + NAD+ + H2O

n-nonanoate + NADH + H+

Homo sapiens

-

-

711836

-

-

?

n-nonanal + NAD+ + H2O

n-nonanoate + NADH + H+

Homo sapiens

-

high specificity

712435

-

-

?

n-nonanal + NAD+ + H2O

n-nonanoate + NADH + H+

Oryctolagus cuniculus

-

-

348706

-

-

?

nonanal + NAD+ + H2O

nonanoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

nonanal + NAD+ + H2O

nonanoate + NADH + H+

Arabidopsis thaliana

Q70DU8

-

740105

-

-

?

o-fluorobenzaldehyde + NAD+ + H2O

o-fluorobenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

81.6% activity compared to p-tolualdehyde

671512

-

-

?

o-fluorobenzaldehyde + NAD+ + H2O

o-fluorobenzoic acid + NADH + H+

Sphingomonas sp. 14DN-61

Q402C7

81.6% activity compared to p-tolualdehyde

671512

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

Acanthopagrus schlegelii

-

-

655237

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

Homo sapiens

-

-

348694

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

Oryctolagus cuniculus

-

n-octylaldehyde

348706

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

Pseudomonas aeruginosa

-

-

348725

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

Rhodococcus erythropolis

Q4F895

-

671542

-

-

?

octanal + NAD+ + H2O

octanoate + NADH

Rhodococcus erythropolis UPV-1

Q4F895

-

671542

-

-

?

octanal + NAD+ + H2O

octanoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

octanal + NAD+ + H2O

octanoate + NADH + H+

Homo sapiens

-

high specificity

712435

-

-

?

p-(dimethylamino)cinnamaldehyde + NAD+ + H2O

p-(dimethylamino)cinnamate + NADH

Homo sapiens

-

-

348694

-

-

?

p-(dimethylamino)cinnamaldehyde + NAD+ + H2O

p-(dimethylamino)cinnamate + NADH

Rattus norvegicus

-

-

348695

-

-

?

p-fluorobenzaldehyde + NAD+ + H2O

p-fluorobenzoic acid + NADH + H+

Sphingomonas sp.

Q402C7

65.5%activity compared to p-tolualdehyde

671512

-

-

?

p-fluorobenzaldehyde + NAD+ + H2O

p-fluorobenzoic acid + NADH + H+

Sphingomonas sp. 14DN-61

Q402C7

65.5%activity compared to p-tolualdehyde

671512

-

-

?

p-hydroxyphenylacetaldehyde + NAD+ + H2O

p-hydroxyphenylacetate + NADH

Ovis aries

-

-

348699, 348704

-

-

?

p-hydroxyphenylacetaldehyde + NAD+ + H2O

p-hydroxyphenylacetate + NADH

Sus scrofa

-

-

348703, 348704

-

-

?

p-methoxybenzaldehyde + NAD+ + H2O

p-methoxybenzoate + NADH + H+

Homo sapiens

-

-

348694

-

-

?

p-methoxybenzaldehyde + NAD+ + H2O

p-methoxybenzoate + NADH + H+

Ovis aries

-

-

348712

-

-

?

p-methoxybenzaldehyde + NAD+ + H2O

p-methoxybenzoate + NADH + H+

Rattus norvegicus

-

-

348717

-

-

?

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoate + NADH

Bos taurus

-

-

348708

-

-

?

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoate + NADH

Homo sapiens

-

-

348694

-

-

?

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoate + NADH

Ovis aries

-

-

348704, 348712

-

-

?

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoate + NADH

Rattus norvegicus

-

-

348695, 348715

-

-

?

p-nitrobenzaldehyde + NAD+ + H2O

p-nitrobenzoate + NADH

Sus scrofa

-

-

348703, 348704

-

-

?

pentanal + NAD+ + H2O

pentanoate + NADH

Homo sapiens

-

-

348694

-

-

?

pentanal + NAD+ + H2O

pentanoate + NADH

Oryctolagus cuniculus

-

n-pentanal

348706

-

-

?

pentanal + NAD+ + H2O

pentanoate + NADH

Rattus norvegicus

-

-

348682, 348707

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

Bos taurus

-

-

348708

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

Escherichia coli

-

best substrate

739888

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

Geobacillus thermodenitrificans

-

37.86% activity compared to formaldehyde

712957

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

Homo sapiens

-

-

348694

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

Rattus norvegicus

-

-

348680, 348682, 348717, 348791

-

-

?

phenylacetaldehyde + NAD+ + H2O

phenylacetate + NADH + H+

Sulfurisphaera tokodaii

-

4.21% activity compared to acetaldehyde

722210

-

-

?

pimelic semialdehyde + NAD+ + H2O

?

Sphingopyxis macrogoltabida

-

-

710936

-

-

?

pimelic semialdehyde + NAD+ + H2O

?

Sphingopyxis macrogoltabida TFA

-

-

710936

-

-

?

propanal + NAD+ + H2O

propanoate + NADH + H+

Acanthopagrus schlegelii

-

-

655237

-

-

?

propanal + NAD+ + H2O

propanoate + NADH + H+

Homo sapiens

-

-

740442

-

-

?

propanal + NAD+ + H2O

propanoate + NADH + H+

Rhodococcus erythropolis

Q4F895

-

671542

-

-

?

propanal + NAD+ + H2O

propanoate + NADH + H+

Rhodococcus erythropolis UPV-1

Q4F895

-

671542

-

-

?

propanal + NAD+ + H2O

propanoate + NADH + H+

Saccharomyces cerevisiae

-

-

654551

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Bos taurus

-

-

348708

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Ctenopharyngodon idella

-

-

348687

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Danio rerio

-

-

673291

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Euglena gracilis

-

-

675118

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Homo sapiens

-

-

348686, 348690, 348693, 348694, 348705, 348720

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Homo sapiens

P05091

-

672038, 672209

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Homo sapiens

-

-

672209

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Homo sapiens

P05091

-

673291

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Nocardia sp.

-

-

348679

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Nocardia sp. 239

-

-

348679

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Oryctolagus cuniculus

-

-

348706, 655317

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Ovis aries

-

-

348699, 348702, 348704, 348711, 348712, 348713

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Pseudomonas aeruginosa

-

-

348725

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Rattus norvegicus

-

-

348680, 348682, 348690, 348695, 348707, 348715, 348717, 656837, 677208

-

-

?

propanal + NAD+ + H2O

propionate + NADH

Sus scrofa

-

-

348704

-

-

?

propanal + NAD+ + H2O

propionate + NADH + H+

Homo sapiens

-

-

712435

-

-

?

propanal + NAD+ + H2O

propionate + NADH + H+

Rattus norvegicus

-

-

348791

-

-

?

propanal + NAD+ + H2O

propionate + NADH + H+

Thermus thermophilus

Q72KD3

-

763724

-

-

?

propanal + NAD+ + H2O

propionate + NADH + H+

Thermus thermophilus ATCC BAA-163

Q72KD3

-

763724

-

-

?

propanal + NAD+ + H2O

propionate + NADH + H+

Thermus thermophilus DSM 7039

Q72KD3

-

763724

-

-

?

propionaldehyde + NAD+ + H2O

propanoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

propionaldehyde + NAD+ + H2O

propanoate + NADH + H+

Lachnoclostridium phytofermentans

A9KN57

-

741416

-

-

?

propionaldehyde + NAD+ + H2O

propanoate + NADH + H+

Vitis labrusca

K9N4H5

-

741147

-

-

?

propionaldehyde + NAD+ + H2O

propanoate + NADH + H+

Vitis quinquangularis

K9N4H5

-

741147

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Bacillus licheniformis

-

-

724399

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Bos taurus

-

-

693311

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Homo sapiens

-

-

712497, 713544, 725451, 726464, 684721

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Homo sapiens

P05091

-

684721, 724716

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Homo sapiens

-

-

724716

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Homo sapiens

P05091, P30837

-

763348

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Klebsiella pneumoniae

-

the activity on propionaldehyde is about 55% of that on valeraldehyde

711536

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Klebsiella pneumoniae DSM 2026

-

the activity on propionaldehyde is about 55% of that on valeraldehyde

711536

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Rattus norvegicus

-

-

692337, 693311

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Rattus norvegicus

P11884

-

712069

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Saccharomyces cerevisiae

-

-

724645

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Sulfurisphaera tokodaii

-

56.22% activity compared to acetaldehyde

722210

-

-

?

propionaldehyde + NAD+ + H2O

propionate + NADH + H+

Sulfurisphaera tokodaii 7

-

56.22% activity compared to acetaldehyde

722210

-

-

?

succinic semialdehyde + NAD+ + H2O

succinate + NADH

Bos taurus

-

-

348708

-

-

?

succinic semialdehyde + NAD+ + H2O

succinate + NADH

Escherichia coli

P76217

-

655643

-

-

?

tetradecanal + NAD+ + H2O

tetradecanoate + NADH

Geobacillus thermoleovorans

-

high activity

697840

-

-

?

tetradecanal + NAD+ + H2O

tetradecanoate + NADH

Geobacillus thermoleovorans B23

-

high activity

697840

-

-

?

trans-2-hexenal + NAD+ + H2O

(E)-hex-2-enoate + NADH + H+

Arabidopsis thaliana

-

-

724222

-

-

?

trans-2-hexenal + NAD+ + H2O

(E)-hex-2-enoate + NADH + H+

Arabidopsis thaliana

Q70DU8

-

740105

-

-

?

trans-cinnamaldehyde + NAD+ + H2O

trans-cinnamate + NADH

Homo sapiens

-

-

348694

-

-

?

trans-cinnamaldehyde + NAD+ + H2O

trans-cinnamate + NADH

Sus scrofa

-

-

348704

-

-

?

valeraldehyde + NAD+ + H2O

valerate + NADH + H+

Escherichia coli

-

-

690591

-

-

?

valeraldehyde + NAD+ + H2O

valerate + NADH + H+

Klebsiella pneumoniae

-

most preferred substrate, 100% activity

711536

-

-

?

valeraldehyde + NAD+ + H2O

valerate + NADH + H+

Klebsiella pneumoniae DSM 2026

-

most preferred substrate, 100% activity

711536

-

-

?

vanillin + NAD+ + H2O

vanillic acid + NADH + H+

Phanerodontia chrysosporium

-

-

711095

-

-

?

vanillin + NAD+ + H2O

vanillic acid + NADH + H+

Sphingomonas sp.

Q402C7

62.3% activity compared to p-tolualdehyde

671512

-

-

?

additional information

?

-

Acanthopagrus schlegelii

-

no activity with benzaldehyde

655237

-

-

?

additional information

?

-

Arabidopsis thaliana

Q70DU8

no activity with NADP+

740105

-

-

?

additional information

?

-

Arabidopsis thaliana

-

no activity with NADP+

740105

-

-

?

additional information

?

-

Arabidopsis thaliana

-

no activity with NADP+. Saturated aldehydes are preferred over unsaturated aldehydes, irrespective of chain length

724222

-

-

?

additional information

?

-

Bos taurus

-

the enzyme also catalyzes esterase reaction with p-nitrophenylacetate + H2O

348708

-

-

?

additional information

?

-

Ctenopharyngodon idella

-

enzyme also posseses esterase activity

348687

-

-

?

additional information

?

-

Culex quinquefasciatus

-

the enzyme may play a role in insecticide resistance

348684

-

-

?

additional information

?

-

Escherichia coli

-

no activity towards 3-hydroxypropionic acid in the presence of NADPH and formaldehyde

690591

-

-

?

additional information

?

-

Escherichia coli

-

the enzyme shows 11% activity with NADP+ compared to NAD+. No activity with phenazine methosulfate

739888

-

-

?

additional information

?

-

Geobacillus thermodenitrificans

-

no activity towards NADP+, tetracosaldehyde, 2-hydroxylbenzaldehyde, ethanol, hexadecanol, acetate, and hexadecanoic acid

712957

-

-

?

additional information

?

-

Geobacillus thermodenitrificans

-

the ALDH has no reductive activity on acetate or hexadecanoic acid

712957

-

-

?

additional information

?

-

Geobacillus thermodenitrificans NG80-2

-

no activity towards NADP+, tetracosaldehyde, 2-hydroxylbenzaldehyde, ethanol, hexadecanol, acetate, and hexadecanoic acid

712957

-

-

?

additional information

?

-

Geobacillus thermodenitrificans NG80-2

-

the ALDH has no reductive activity on acetate or hexadecanoic acid

712957

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation

655317

-

-

?

additional information

?

-

Homo sapiens

-

no activity with formaldehyde

684721

-

-

?

additional information

?

-

Homo sapiens

P05091

no activity with formaldehyde

684721

-

-

?

additional information

?

-

Homo sapiens

-

involved in detoxication of a variety of aldehydes of plant origin, as well as those formed during food processing, or applied as food additives

695926

-

-

?

additional information

?

-

Homo sapiens

-

ALDH2 is a direct downstream substrate of epsilon protein kinase C

711691

-

-

?

additional information

?

-

Homo sapiens

P05091

ALDH2 denitrates nitroglycerin to 1,2-glyceryl dinitrate and nitrite but also catalyzes reduction of nitroglycerin to NO. In addition to aldehyde oxidation, ALDH2 catalyzes ester hydrolysis. The esterase activity is stimulated by NAD+, but the cofactor is not essential for the reaction

712375

-

-

?

additional information

?

-

Homo sapiens

-

no activity with NADP+ and unsaturated aldehydes like trans-2-hexenal, trans-2-nonenal, and trans-2 dodecenal

711836

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme shows esterase activity with 4-nitrophenyl acetate

711836

-

-

?

additional information

?

-

Homo sapiens

P05091

the enzyme shows esterase activity with 4-nitrophenyl acetate

712375

-

-

?

additional information

?

-

Homo sapiens

-

no activity with aromatic aldehydes such as benzaldehyde, nitrobenzaldehyde, methoxybenzaldehyde, or phenylacetaldehyde

726464

-

-

?

additional information

?

-

Homo sapiens

Q8IZ83

no activity with hexanal, propanal, nonanal, acetaldehyde and aminoadipate semialdehyde

763362

-

-

-

additional information

?

-

Homo sapiens

-

no activity with hexanal, propanal, nonanal, acetaldehyde and aminoadipate semialdehyde

763362

-

-

-

additional information

?

-

Klebsiella pneumoniae

-

no appreciable activity is observed on formaldehyde

711536

-

-

?

additional information

?

-

Klebsiella pneumoniae

A6T8Z5

no activity with propionaldehyde, butyraldehyde, valeraldehyde, isovaleraldehyde, and furaldehyde

740167

-

-

?

additional information

?

-

Klebsiella pneumoniae DSM 2026

-

no appreciable activity is observed on formaldehyde

711536

-

-

?

additional information

?

-

Klebsiella pneumoniae MCG 78578

A6T8Z5

no activity with propionaldehyde, butyraldehyde, valeraldehyde, isovaleraldehyde, and furaldehyde

740167

-

-

?

additional information

?

-

Loktanella sp.

-

enzyme LsALDH16 also exhibits esterase activity with 4-nitrophenylacetate (pNPA) as substrate in the absence of NAD+, kinetics, overview

763362

-

-

-

additional information

?

-

Mus musculus

-

Aldh3a1 metabolizes toxic aldehydes produced by light-induced lipid peroxidation

698380

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation

655317

-

-

?

additional information

?

-

Ovis aries

-

-

348713

-

-

?

additional information

?

-

Ovis aries

-

the enzyme also catalyzes esterase reaction with p-nitrophenylacetate + H2O

348702

-

-

?

additional information

?

-

Ovis aries

-

enzyme also catalyzes esterase reaction with p-nitrophenyl pivalate + H2O

348702

-

-

?

additional information

?

-

Pseudomonas aeruginosa

-

constitutive enzyme

348725

-

-

?

additional information

?

-

Pseudomonas putida

-

the enzyme is only marginally active with acetaldehyde, while longer-chain aliphatic aldehydes are poor substrates

680440

-

-

?

additional information

?

-

Rattus norvegicus

-

the microsomal membrane-bound enzyme is expected to catalyze the oxidation of such water-insoluble aldehydes produced on the surface of the microsomal membrane. The enzyme may also be involved in the conversion of fatty acids to alpha,omega-dicarboxylic acids

348716

-

-

?

additional information

?

-

Rattus norvegicus

-

the majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation

656837

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

enzyme ALD2 and ALD3 are stress-induced and glucose-repressed

348685

-

-

?

additional information

?

-

Saccharomyces cerevisiae

P54115

to assess the degree of formaldehyde degradation, luminescence measurements in Vibrio fischeri for formaldehyde toxicity are conducted

763375

-

-

-

additional information

?

-

Saccharomyces cerevisiae

-

to assess the degree of formaldehyde degradation, luminescence measurements in Vibrio fischeri for formaldehyde toxicity are conducted

763375

-

-

-

additional information

?

-

Saccharomyces cerevisiae ATCC 204508

P54115

to assess the degree of formaldehyde degradation, luminescence measurements in Vibrio fischeri for formaldehyde toxicity are conducted

763375

-

-

-

additional information

?

-

Sphingopyxis macrogoltabida

-

no activity is detected when NADP+ is used as the oxidant instead of NAD+

710936

-

-

?

additional information

?

-

Sphingopyxis macrogoltabida TFA

-

no activity is detected when NADP+ is used as the oxidant instead of NAD+

710936

-

-

?

additional information

?

-

Sulfurisphaera tokodaii

-

no activity with methanol, ethanol and isopropanol

722210

-

-

?

additional information

?

-

Sulfurisphaera tokodaii 7

-

no activity with methanol, ethanol and isopropanol

722210

-

-

?