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1.2.1.3: aldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.3

Reaction

an aldehyde
+
NAD+
+
H2O
=
a carboxylate
+
NADH
+
H+

Synonyms

ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALD6, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 16, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 1B1, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde dehydrogenase 6, aldehyde dehydrogenase 7A1, aldehyde dehydrogenase class 1, aldehyde dehydrogenase type 2, Aldehyde dehydrogenase [NAD+], Aldehyde dehydrogenase, cytosolic, Aldehyde dehydrogenase, microsomal, aldehyde dehydrogenase-2, aldehyde dehydrogenase7, aldehyde:NAD+ oxidoreductase, ALDH, ALDH 2, ALDH I, ALDH II, ALDH-2, ALDH-E1, ALDH-E2, ALDH1, ALDH1-NL, ALDH16, ALDH1A1, Aldh1a2, Aldh1a3, Aldh1a7, Aldh1b1, ALDH2, ALDH2(1), ALDH2(2), ALDH2(3), ALDH22A1, ALDH2B8, ALDH2C4, ALDH3A1, ALDH3A2, Aldh3b1, ALDH3H1, ALDH3I1, ALDH5A, ALDH7, Aldh7a1, ALDH7B4, Aldh8a1, ALDHI, ALDHTt, ALDHX, ALHDII, Allergen Alt a 10, aryl-aldehyde dehydrogenases, BADH, benzaldehyde dehydrogenase, Brassica turgor-responsive/drought-induced gene 26 protein, Bt-Aldh, Btg-26, class 1 aldehyde dehydrogenase, class 2 aldehyde dehydrogenase, class I ALDH, CoA-independent aldehyde dehydrogenase, coniferyl-aldehyde dehydrogenase, Cphy_1178, EC 1.1.1.70, ETA-crystallin, FeaB-K-12, gamma-aminobutyraldehyde dehydrogenase, hALDH2, HsALDH16A1, irreversible NAD+-dependent aldehyde dehydrogenase, K(+)-ACDH, K(+)-activated acetaldehyde dehydrogenase, KGSADH, LsALDH16, m-methylbenzaldehyde dehydrogenase, Matured fruit 60 kDa protein, MF-60, Mg(2+)-ACDH, Mg(2+)-activated acetaldehyde dehydrogenase, mitochondrial aldehyde dehydrogenase, More, NAD+-dependent aldehyde dehydrogenase, NAD+-dependent ALDH, NAD+-linked aldehyde dehydrogenase, NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase, NAD+-specific ALDH, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, Non-lens ALDH1, p-ALDH2, P51, phenylacetaldehyde dehydrogenase, PhnN, phnY, phosphonoacetaldehyde dehydrogenase, phosphonoacetaldehyde oxidase, PM-ALDH9, PnAA dehydrogenase, propionaldehyde dehydrogenase, PuuC, R-aminobutyraldehyde dehydrogenase, RALDH, RALDH(II), RalDH1, Retinal dehydrogenase, retinal dehydrogenase type I, sALDH, salvery aldehyde dehydrogenase, ThnG, TTC0513, Turgor-responsive protein 26G, yALDH, YneI

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.3 aldehyde dehydrogenase (NAD+)

KM Value

KM Value on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.023
(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde
-
membrane-bound isoenzyme ALDH
0.001
(R)-trans-4-hydroxy-2-nonenal
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37°C
0.0007
(S)-trans-4-hydroxy-2-nonenal
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37°C
0.0358
1,N6-ethenoadenine dinucleotide
-
isoenzyme E3
0.00015 - 0.0016
1-formyl-6-methylpyrene
0.000027 - 0.004
1-formyl-8-methylpyrene
0.0009 - 0.004
1-formylpyrene
0.0000032
2,4-dinitrobenzaldehyde
-
enzyme ALDH-2
0.00038 - 0.011
2-formylpyrene
0.000008 - 0.00046
2-naphthaldehyde
0.00024
2-naphthalene carboxylate
-
apparent Km value, diphosphate buffer, pH 8.1, cofactor NADH
0.0053
2-nonenal
-
pH and temperature not specified in the publication
0.0005 - 0.017
3,4-dihydroxyphenyl acetaldehyde
0.0004 - 0.0042
3,4-dihydroxyphenylacetaldehyde
0.00033
3,4-dimethoxybenzaldehyde
-
enzyme ALDH-2
0.022
3-acetylpyridine-NAD+
-
-
0.29 - 0.49
3-hydroxypropionaldehyde
0.12
3-hydroxypropionic acid
-
with NADH as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37°C
3.3
3-oxopropyl phosphonate
wild type enzyme, at pH 7.5 and 30°C
0.00196
3-Pyridinecarboxaldehyde
-
enzyme ALDH-2
0.0001 - 0.0003
4-(dimethylamino)cinnamaldehyde
0.005 - 0.014
4-aminobutyrate
0.014
4-cyanobenzaldehyde
-
-
0.0042
4-Dimethylaminobenzaldehyde
-
recombinant ALDH3A1
0.00004 - 0.00078
4-formylpyrene
3.383
4-hydroxy-2-nonenal
-
at 25°C, pH not specified in the publication
0.155
4-hydroxy-3-methoxybenzaldehyde
-
recombinant ALDH3A1
0.0021 - 0.0403
4-hydroxynonenal
0.000065
4-methoxy-1-naphthaldehyde
-
enzyme ALDH-2
0.019
4-methoxybenzaldehyde
-
recombinant ALDH3A1
0.0002
4-methyoxy-1-naphthaldehyde
-
enzyme ALDH-1
0.0043
4-nitrophenyl acetate
-
-
0.0000063
5-(dimethylamino)-2-naphthaldehyde
-
enzyme ALDH-1
0.0000004 - 0.0000025
5-bromo-1-naphthaldehyde
0.026
5-hydroxyindol acetaldehyde
-
membrane-bound isoenzyme ALDH
0.0189
5-methoxyindole-3-carboxaldehyde
-
enzyme ALDH-2
0.0000004 - 0.000011
5-nitro-1-naphthaldehyde
0.00069
6,7-dimethoxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.0000023
6-(dimethylamino)-2-naphthaldehyde
-
enzyme ALDH-2
0.0017 - 0.02
6-dimethylamino-2-naphthaldehyde
0.00016 - 0.0002
6-methoxy-2-naphthaldehyde
0.0054
6-methoxy-2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
0.00213
7-(dimethylamino)-2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
0.000062
7-(dimethylamino)-coumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.00006
7-acetoxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.15
7-hydroxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.05
7-methoxy-2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
0.00028
7-methoxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.00005 - 80
acetaldehyde
0.017
acetylaldehyde
-
at substrate concentrations 0-0.07 mM
0.009
acrolein
-
wild type isoform ALDH1A1, in 100 mM sodium diphosphate (pH 9.5), at 25°C
0.0093
all-trans-retinal
-
at pH 8.0 and 25°C
0.064 - 0.63
alpha-aminoadipate semialdehyde
0.00093
alpha-phenylpropanal
-
enzyme ALDH-2
0.000018 - 50
benzaldehyde
0.0411 - 0.26
Betaine aldehyde
0.0234
betaNAD+
-
isoenzyme E3
0.00019 - 0.045
Butanal
0.26 - 1.74
Butyraldehyde
0.00055
cinnamaldehyde
-
-
0.006
cinnamic aldehyde
-
recombinant ALDH3A1
0.032
crotonaldehyde
-
-
1.136
D-glyceraldehyde
-
-
0.326
deamino-NAD+
-
-
0.0000029 - 91
decanal
8.51
DL-glyceraldehyde
-
in 50 mM Tris/HCl, at pH 8.0 and 80°C
6.12
DL-glyceraldehyde 3-phosphate
-
in 50 mM Tris/HCl, at pH 8.0 and 80°C
0.005 - 0.02
dodecanal
0.000054
fluorene-2-carboxaldehyde
-
enzyme ALDH-1
0.031 - 0.7
formaldehyde
0.0009 - 0.56
Glutaraldehyde
0.183
glutathione-4-oxonon-2-enal
-
-
0.17 - 7.374
glyceraldehyde
0.097 - 0.372
glyceraldehyde 3-phosphate
0.046
glycoaldehyde
-
isoenzyme 2, pH 7.4
0.005 - 0.69
glycolaldehyde
0.043
Glyoxal
-
-
0.000018 - 0.035
Heptanal
0.00003 - 0.072
hexanal
2.9
hexanaldehyde
at pH 8.0 and 21°C
0.0005
hydrocinnamaldehyde
-
enzyme ALDH-2
0.0007 - 0.001
indole 3-acetaldehyde
0.00015 - 0.002
Indole-3-acetaldehyde
0.01 - 0.02
Indole-3-aldehyde
-
enzyme ALDH-2
0.03 - 0.036
Isobutanal
0.21 - 0.68
Isovaleraldehyde
0.00009
m-methoxybenzaldehyde
-
enzyme ALDH-2
0.000018
m-methylbenzaldehyde
-
enzyme ALDH-2
0.0043 - 0.466
malondialdehyde
0.0086 - 1.876
methylglyoxal
0.043
Monochloroacetaldehyde
-
-
0.11
N-acetyl-4-aminobutyrate
-
enzyme from liver
0.944
N-guanine dinucleotide
-
isoenzyme E3
0.0008 - 0.0285
n-nonanal
0.0003 - 16
NAD+
0.088
NADH
-
at pH 7.0 and 55°C
0.27 - 8.47
NADP+
0.008 - 0.065
Nonanal
0.0008
o-methoxybenzaldehyde
-
enzyme ALDH-2
1.3
o-methylbenzaldehyde
-
enzyme ALDH-2
0.0000063
o-nitrobenzaldehyde
-
enzyme ALDH-2
0.000012 - 0.029
octanal
0.172
oxidized nicotinamide hypoxanthine dinucleotide
-
isoenzyme E3
0.00002
p-(dimethylamino)-benzaldehyde
-
enzyme ALDH-2
0.00006
p-(dimethylamino)benzaldehyde
-
enzyme ALDH-1
0.000005 - 0.00142
p-(dimethylamino)cinnamaldehyde
0.024
p-Carboxybenzaldehyde
-
-
0.000018 - 0.0004
p-Methoxybenzaldehyde
0.000017
p-methylbenzaldehyde
-
enzyme ALDH-2
0.000007 - 2
p-nitrobenzaldehyde
0.0000007
p-nitrocinnamaldehyde
-
enzyme ALDH-2
0.000034 - 0.006
pentanal
2.2
pentanaldehyde
at pH 8.0 and 21°C
0.000004
phenanthrene-9-carboxaldehyde
-
enzyme ALDH-2
0.000029 - 0.027
phenylacetaldehyde
0.0032 - 0.5
phosphonoacetaldehyde
0.000008 - 2.76
propanal
0.0028 - 12
propionaldehyde
0.013
Pyruvic aldehyde
-
-
0.00033
quinoline-3-carboxaldehyde
-
enzyme ALDH-2
0.0028
quinoline-4-carboxaldehyde
-
enzyme ALDH-2
0.69 - 3.54
Succinic semialdehyde
0.18 - 0.199
trans-2-hexenal
0.003 - 0.0322
trans-2-nonenal
0.000035 - 0.0004
trans-cinnamaldehyde
0.14 - 0.24
Valeraldehyde
additional information
additional information
-