1.2.1.13: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), go to the full flat file.

Word Map on EC 1.2.1.13

1.2.1.13

chloroplast

gapdhs

phosphoribulokinase

nadp-linked

4.1.1.39

calvin

2.7.1.19

2.7.2.3

1,3-bisphosphoglycerate

nad-specific

calvin-benson

triose-p

sedoheptulose

ribulose-5-phosphate

medicine

Reaction

Synonyms

A2B2-GAPDH, A2B2-glyceraldehyde-3-phosphate dehydrogenase, A4 glyceraldehyde 3-phosphate dehydrogenase, A4-GAPDH, At1g12900, At3g26650, D-glyceraldehyde-3-phosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate phosphorylating), GapA, GapA-1, GAPA1, GAPA2, GapB, GAPC, GAPD, GAPDH, GAPDH (A4), glyceraldehyde 3-phosphate dehydrogenase (NADP), glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate phosphorylating), glyceraldehyde-3-dehydrogenase, glyceraldehyde-3-P dehydrogenase, glyceraldehyde-3-phosphate dehhydrogenase (NADP+) (phoshphorylating), glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+), glyceraldehyde-P dehydrogenase, GraP-DH, NAD(P)-GAPDH, NADP(H)-glyceraldehyde-3-phosphate dehydrogenase, NADP+-dependent G-3-P dehydrogenase, NADP+-dependent gapB, NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase, NADP+-GAPDH, NADP-dependent GAPDH, NADP-dependent glyceradehdye-3-phosphate dehydrogenase, NADP-dependent glyceraldehyde 3-phosphate dehydrogenase, NADP-dependent glyceraldehyde phosphate dehydrogenase, NADP-dependent glyceraldehydephosphate dehydrogenase, NADP-G3PDH, NADP-GAPDH, NADP-glyceraldehyde phosphate dehydrogenase, NADP-glyceraldehyde-3-phosphate dehydrogenase, NADP-GPD, NADP-triose phosphate dehydrogenase, NADPH-D-GA3P, NADPH-glyceraldehyde-3-phosphate dehydrogenase, NAPD-linked glyceraldehyde-3-P dehydrogenase, Ov-GAPDH, phosphorylating GAP dehydrogenase, phosphorylating glyceraldehyde-3-phosphate dehydrogenase, photosynthetic GAPDH, SSO0528, triosephosphate dehydrogenase (NADP+)

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

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Results	in table
53	Activating Compound
81	AA Sequence
5	Application
1	CAS Registry Number
25	Cloned(Commentary)
121	Cofactor
12	Crystallization (Commentary)
15	Disease/ Diagnostics
4	Expression
16	General Information
1	General Stability
2	IC50 Value
24	Inhibitors
7	Ki Value [mM]
117	KM Value [mM]
45	Localization
1	Metals/Ions
75	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
135	Organism
2	Oxidation Stability
6	Pathway
153	PDB ID
16	pH Optimum
1	pH Range
2	pI Value
37	Protein Variants
36	Purification (Commentary)
2	Reaction
15	Reaction Type
114	Reference
52	Source Tissue
45	Specific Activity [micromol/min/mg]
2	Storage Stability
80	Substrates and Products (Substrate)
51	Subunits
122	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
15	Temperature Stability [°C]
41	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.2.1.13 - glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

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3-phospho-D-glyceroyl phosphate

Sulfurisphaera tokodaii

725013

6-Hydroxydopamine

Oryctolagus cuniculus

676125

chloroplast protein CP12

Chlamydomonas reinhardtii

the chloroplast protein CP12 behaves as a negative regulator of GAPDH activity

673549

CP-12

Chlamydomonas reinhardtii

724306

Cu2+

Pisum sativum

inhibition is reversed by EDTA

288036

cystamine

Spinacia oleracea

inhibitory when the enzyme is activated by effectors

288034

DL-glyceraldehyde 3-phosphate

Sulfurisphaera tokodaii

725013

GAPDH segregator

2 entries

H2O2

Synechococcus elongatus PCC 7942 = FACHB-805

rapid reversible deactivation of untreated and GSH-treated enzyme preparation, GSH reverses the inhibition

288008

iodoacetamide

2 entries

iodoacetate

Spinacia oleracea

preincubation with glyceraldehyde-phosphate, 10fold molar excess over iodoacetate, prevents inactivation

288022

NAD+

3 entries

NADH

Sulfurisphaera tokodaii

strong inhibition with excess co-substrate s observed and no activity is observed with over 2 mM NADH

725013

NADP+

Sulfurisphaera tokodaii

NADPH

NaHS

sulfite

non-competitive inhibitor with respect to both NADPH and 3-phosphoglycerate

288025

thioredoxin

Spinacia oleracea

a regulatory disulfide between Cys359 and Cys358 of the C-terminal extension of GapB does form in presence of oxidized thioredoxin. This covalent modification is required for the NAD+-dependent association into higher oligomers and inhibition of the NADPH-dependent activity

656096

additional information

Asterionella formosa

the activity of the GAPDH-CP12 complex is not affected by addition of bovine serum albumin, Rubisco, EC 4.1.1.39, or phosphoribulokinase, PRK EC 2.7.1.19. Incubation of GAPDH alone with NADPH, DTT or NADP has no effect on its activity

743366