1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) This is an abbreviated version! For detailed information about glyceraldehyde-3-phosphate dehydrogenase (phosphorylating), go to the full flat file .
Reaction
D-glyceraldehyde 3-phosphate +
phosphate +
NAD+ =
3-phospho-D-glyceroyl phosphate +
NADH +
H+
Synonyms 3-phosphoglyceraldehyde dehydrogenase, A4-GAPDH, A4-glyceraldehyde-3-phosphate dehydrogenase, AB-GAPDH, AnBn-GAPDH, AsGAPDH, At3g04120, BARS-38, CbbG, CgGAP, Clo1313_2095, complement-C3-binding protein, CP 17/CP 18, Ctherm_Gapdh, cytosolic NAD-dependent glyceraldehyde 3-P dehydrogenase, cytosolic phosphorylating glyceraldehyde-3-phosphate dehydrogenase, D-glyceraldehyde-3-phosphate dehydrogenase, D-glyceraldehyde-3-phosphate: NAD+ oxidoreductase (phosphorylating), dehydrogenase, glyceraldehyde phosphate, dihydrogenase, glyceraldehyde phosphate, EcGAPDH, EcGAPDH1, FgGAPDH, FhGAPDH, G3PD, G3PDH, Ga3P dehydrogenase, Ga3PDHase, GADPH, GAP, GAP1, gap2, GapA, GapB, GAPC, GapC-1, GapC1, GapC2, GAPCp, GAPCp1, GAPCp2, GAPD, GAPDH, GAPDH type 1, GAPDH1, GAPDH2, GAPDH3, GAPDHS, GAPDS, GAPN, GBS GAPDH, glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase-S, glyceraldehyde phosphate dehydrogenase (NAD), glyceraldehyde-3 phosphate dehydrogenase, glyceraldehyde-3-P-dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NAD), glyceraldehyde-3-phosphate dehydrogenase 1, glyceraldehyde-3-phosphate dehydrogenase, type I, glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein, glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS, glyceraldehyde-3-phosphate dehydrogenases, GPD, GPD2, Gra3PDH, GraP-DH, H.c-C3BP, hGAPDH, HsGAPDH, kmGAPDH1p, Larval antigen OVB95, Major larval surface antigen, Mtb-GAPDH, NAD+-dependent GAPDH, NAD+-dependent glyceraldehyde 3-phosphate dehydrogenase, NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase, NAD+-G-3-P dehydrogenase, NAD+-GAPDH, NAD-dependent Ga3PDHase, NAD-dependent glyceraldehyde 3-phosphate dehydrogenase, NAD-dependent glyceraldehyde phosphate dehydrogenase, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase, NAD-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, NAD-dependent phosphorylating glyceraldehyde-3-phosphate dehydrogenase, NAD-G3PDH, NAD-GAPDH, NADH-glyceraldehyde phosphate dehydrogenase, P-37, p-GAPDH, PfGAPDH, phosphoglyceraldehyde dehydrogenase, phosphorylating NAD+-dependent GAPDH, Plasmin receptor, Plasminogen-binding protein, plastidial glyceraldehyde-3-phosphate dehydrogenase, pmGAPDH, PyGapdh, rmGAPDH, Rv1436, somatic GAPD, somatic glyceraldehyde 3-phosphate dehydrogenase, sperm-specific GAPDS, sperm-specific glyceraldehyde 3-phosphate dehydrogenase, sperm-specific glyceraldehyde-3-phosphate dehydrogenase, TaeNAD-GAPDH, TagapC, TDH1, TDH2, TDH3, TLAb, triose phosphate dehydrogenase, UDG, uracil-DNA glycosylase, vGPD
ECTree
Source Tissue
Source Tissue on EC 1.2.1.12 - glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
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primary culture
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infected with Japanese encephalitis virus
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human juvenile costal chondrocyte cell
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lung, microvascular
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287900 , 287910 , 287932 , 287945 , 287950 , 657393 , 673629 , 685025 , 688250 , 695298 , 712640 , 725592 brenda
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in both fetal and senior cells, considerable GAPDH is present in intracellular domains characterized by significantly reduced catalysis. Human cells contain significant intracellular levels of enzymatically inactive GAPDH which is age-independent
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moderate expression
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KB cell line ATCC CCL17
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ventricular myocytes isolated from adult Sprague-Dawley rats
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striatal
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normal human ovarian surface epithelial cell line
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a multimeric high-molecular-weight glyceraldehyde-3-phosphate dehydrogenase, the isozyme is secreted. Low levels of non-serum-specific isozyme GAPDH. The serum-specific high-molecular weight isozyme is also secreted from cancer cells
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GAPDHS displays significantly higher expression in uveal melanoma (UM) than in normal controls
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weak expression
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strong est expression
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purified from erythrocytes
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rod outer segment
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strong expression
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weak expression
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moderate expression
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poor expression
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moderate expression
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weak expression
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moderate expression
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infected with Japanese encephalitis virus
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expressing Bcl-2, overproduction of the Bcl-2 protein does not change the non-native GAPDH localization in the growing HeLa-Bcl-2 cells
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immunodetection of GAPDH and its adducts with apurinic/apyrimidinic DNA in cell extracts
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staining of HeLa cells with mAbs 6C5 reveals the predominant accumulation of the non-native forms of GAPDH, i.e. dimers, monomers, the denatured forms of GAPDH, in the nucleus during normal growth
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strong expression
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moderate expression
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expression slowly decreases in the dark and is stable in sucrose-treated leaves
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poor expression
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predominant expression
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microvascular endothelial cell
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flight muscle, located at or near the Z-band cross-striations
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isoenzyme 2 is body-wall muscle specific activity located within the actin-containing I and A zones of the nematodes sarcomers
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skeletal muscle
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Hippoglossus sp.
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skeletal muscle
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poor expression
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predominant expression
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287900 , 287904 , 287926 , 287933 , 287953 , 287957 , 287959 , 287965 , 287967 , 287969 , 287972 , 287978 , 287981 , 288344 , 654080 , 654437 , 670846 , 672402 , 673706 , 685292 , 686305 , 686481 , 686849 , 687602 , 689409 , 696421 , 698989 brenda
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of back and hind legs
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tail muscle
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skeletal muscle
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nitrogen fixing
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in castor oil seed, the NAD-GAPDH activity slightly increases and total protein levels do not significantly change in the first half of seed development but both abruptly decreases in the second part of development, when triacylglycerol synthesis and storage begin
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NAD-GAPDH activity gradually increases along wheat seed development, but protein levels and phosphorylation status exhibit only slight changes
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for structural comparison
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GAPDS exists in sperms bound to the fibrous sheath of the flagellum
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ejaculated sperm cells, localization of the GAPDHS protein in the sperm head, immunologic analysis, in the principal piece and acrosomal part of the sperm cells, overview
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sperm-specific glyceraldehyde 3-phosphate dehydrogenase, restricted enzyme expression during spermatogenesis
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epididymal spermatozoa, localization of the GAPDHS protein in the sperm head, immunologic analysis, in the principal piece and acrosomal part of the sperm cells, overview
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sperm-specific glyceraldehyde 3-phosphate dehydrogenase, restricted enzyme expression during spermatogenesis
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epididymal spermatozoa, localization of the GAPDHS protein in the sperm head, immunologic analysis, in the principal piece and acrosomal part of the sperm cells, overview
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strong expression
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poor expression
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additional information
ubiquitously expressed in all stages of the organism
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isoenzyme 1 is present in all cells
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additional information
astrocytes express SRR in the subiculum of human hippocampal formation
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additional information
sperm-specific enzyme GAPDHS is highly expressed in melanoma cells
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additional information
mRNA is detected ubiquitously in all tissues examined
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mRNA is detected ubiquitously in all tissues examined
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additional information
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mRNA is detected ubiquitously in all tissues examined
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additional information
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COS7L cells are used for transfection
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