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1.2.1.10: acetaldehyde dehydrogenase (acetylating)

This is an abbreviated version!
For detailed information about acetaldehyde dehydrogenase (acetylating), go to the full flat file.

Word Map on EC 1.2.1.10

Reaction

acetaldehyde
+
CoA
+
NAD+
=
acetyl-CoA
+
NADH
+
H+

Synonyms

4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase, ACDH, acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating], acetaldehyde-alcohol dehydrogenase, acetyl-CoA reductase, acylating acetaldehyde dehydrogenase, AdhE, ADHES77, aldehyde dehydrogenase, aldehyde dehydrogenase (acylating), aldehyde/alcohol dehydrogenase, ALDH, BAD, bi-functional alcohol/aldehyde dehydrogenase, bifunctional acetaldehyde-alcohol dehydrogenase, BphJ, CoA-acylating aldehyde dehydrogenase, CoA-dependent aldehyde dehydrogenase, coenzyme A linked aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, DmpF, DmpFG, MhpF, More, NAD+/CoA-dependent aldehyde dehydrogenase, nonphosphorylating acylating aldehyde dehydrogenase, PduP, Teth514_0627, Teth514_1942, Tsac_0416, TTHB247

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.10 acetaldehyde dehydrogenase (acetylating)

Reference

Reference on EC 1.2.1.10 - acetaldehyde dehydrogenase (acetylating)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hillmer, P.; Gottschalk, G.
Solubilization and partial characterization of particulate dehydrogenases from Clostridium kluyveri
Biochim. Biophys. Acta
334
12-23
1974
Clostridium kluyveri
-
Manually annotated by BRENDA team
Burdette, D.; Zeikus, J.G.
Purification of acetaldehyde dehydrogenase and alcohol dehydrogenases from Thermoanaerobacter ethanolicus 39E and characterization of the secondary-alcohol dehydrogenase (2 degrees Adh) as a bifunctional alcohol dehydrogenase-acetyl-CoA reductive thioesterase
Biochem. J.
302
163-170
1994
Thermoanaerobacter ethanolicus, Thermoanaerobacter ethanolicus 39E
Manually annotated by BRENDA team
Jones, P.W.; Turner, J.M.
Interrelationships between the enzymes of ethanolamine metabolism in Escherichia coli
J. Gen. Microbiol.
130
299-308
1984
Escherichia coli
Manually annotated by BRENDA team
Kessler, D.; Leibrecht, I.; Knappe, J.
Pyruvate-formate-lyase-deactivase and acetyl-CoA reductase activities of Escherichia coli reside on a polymeric protein particle encoded by adhE
FEBS Lett.
281
59-63
1991
Escherichia coli
Manually annotated by BRENDA team
Shone, C.C.; Fromm, H.J.
Steady-state and pre-steady-state kinetics of coenzyme A linked aldehyde dehydrogenase from Escherichia coli
Biochemistry
20
7494-7501
1981
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Hosoi, N.; Ozaki, C.; Kitamoto, Y.; Ichikawa, Y.
Purification and properties of aldehyde dehydrogenase (acylating) from propionibacterium freudenreichii
J. Ferment. Technol.
57
418-427
1979
Propionibacterium freudenreichii
-
Manually annotated by BRENDA team
Kazahaya, T.; Kawai, K.; Yashima, S.; Sasaki, Y.
Aerobic dissimilation of glucose by heterolactic bacteria. III. Aldehyde dehydrogenase and alcohol dehydrogenase of Leuconostoc mesenteroides
J. Gen. Appl. Microbiol.
18
43-55
1972
Leuconostoc mesenteroides
-
Manually annotated by BRENDA team
Burton, R.M.; Stadtman, E.R.
The oxidation of acetaldehyde to acetyl coenzyme A
J. Biol. Chem.
202
873-890
1953
Clostridium kluyveri
Manually annotated by BRENDA team
Hillmer, P.; Gottschalk, G.
Particulate nature of enzymes involved in the fermentation of ethanol and acetate by Clostridium kluyveri
FEBS Lett.
21
351-354
1972
Clostridium kluyveri
Manually annotated by BRENDA team
Rudolph, F.B.; Purich, D.L.; Fromm, H.J.
Coenzyme A-linked aldehyde dehydrogenase from Escherichia coli. I. Partial purification, properties, and kinetic studies of the enzyme
J. Biol. Chem.
243
5539-5545
1968
Escherichia coli
Manually annotated by BRENDA team
Clark, D.P.; Cronan, J.E., Jr.
Acetaldehyde coenzyme A dehydrogenase of Escherichia coli
J. Bacteriol.
144
179-184
1980
Escherichia coli
Manually annotated by BRENDA team
Yan, R.T.; Chen, J.S.
Coenzyme A-acylating aldehyde dehydrogenase from Clostridium beijerinckii NRRL B592
Appl. Environ. Microbiol.
56
2591-2599
1990
Clostridium beijerinckii, Clostridium beijerinckii NRRL B592
Manually annotated by BRENDA team
Powlowski, J.; Sahlman, L.; Shingler, V.
Purification and properties of the physically associated meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600
J. Bacteriol.
175
377-385
1993
Pseudomonas sp., Pseudomonas sp. CF 600
Manually annotated by BRENDA team
Smith, L.T.; Kaplan, N.O.
Purification, properties, and kinetic mechanism of coenzyme A-linked aldehyde dehydrogenase from Clostridium kluyveri
Arch. Biochem. Biophys.
203
663-675
1980
Clostridium kluyveri
Manually annotated by BRENDA team
Sanchez, L.B.
Aldehyde dehydrogenase (CoA-acetylating) and the mechanism of ethanol formation in the amitochondriate protist, Giardia lamblia
Arch. Biochem. Biophys.
354
57-64
1998
Giardia intestinalis, Giardia intestinalis WB / CC 30957
Manually annotated by BRENDA team
Manjasetty, B.A.; Croteau, N.; Powlowski, J.; Vrielink, A.
Crystallization and preliminary x-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase-aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600
Acta Crystallogr. Sect. D
57
582-585
2001
Pseudomonas sp., Pseudomonas sp. CF 600
Manually annotated by BRENDA team
Platt, A.; Shingler, V.; Taylor, S.C.; Williams, P.A.
The 4-hydroxy-2-oxovalerate aldolase and acetaldehyde dehydrogenase (acylating) encoded by the nahM and nahO genes of the naphthalene catabolic plasmid pWW60-22 provide further evidence of conservation of meta-cleavage pathway gene sequences
Microbiology
141
223-233
1995
Pseudomonas sp., Pseudomonas sp. NCIMB9816
-
Manually annotated by BRENDA team
Manjasetty, B.A.; Powlowski, J.; Vrielink, A.
Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate
Proc. Natl. Acad. Sci. USA
100
6992-6997
2003
Pseudomonas sp., Pseudomonas sp. CF 600
Manually annotated by BRENDA team
Koo, O.K.; Jeong, D.W.; Lee, J.M.; Kim, M.J.; Lee, J.H.; Chang, H.C.; Kim, J.H.; Lee, H.J.
Cloning and characterization of the bifunctional alcohol/acetaldehyde dehydrogenase gene (adhE) in Leuconostoc mesenteroides isolated from kimchi
Biotechnol. Lett.
27
505-510
2005
Leuconostoc mesenteroides (Q5RLY6), Leuconostoc mesenteroides LMC7 (Q5RLY6)
Manually annotated by BRENDA team
Lei, Y.; Pawelek, P.D.; Powlowski, J.
A shared binding site for NAD+ and coenzyme A in an acetaldehyde dehydrogenase involved in bacterial degradation of aromatic compounds
Biochemistry
47
6870-6882
2008
Escherichia coli, Escherichia coli XL2-Blue
Manually annotated by BRENDA team
Zhao, Y.; Lei, M.; Wu, Y.; Wang, C.; Zhang, Z.; Deng, F.; Wang, H.
Molecular cloning and expression of the complete DNA sequence encoding NAD+-dependent acetaldehyde dehydrogenase from Acinetobacter sp. strain HBS-2
Ann. Microbiol.
59
97-104
2009
Acinetobacter sp. HBS-2 (A5JT11)
-
Manually annotated by BRENDA team
Baker, P.; Carere, J.; Seah, S.Y.
Substrate specificity, substrate channeling, and allostery in BphJ: an acylating aldehyde dehydrogenase associated with the pyruvate aldolase BphI
Biochemistry
51
4558-4567
2012
Paraburkholderia xenovorans (Q79AF6)
Manually annotated by BRENDA team
Fischer, B.; Boutserin, S.; Mazon, H.; Collin, S.; Branlant, G.; Gruez, A.; Talfournier, F.
Catalytic properties of a bacterial acylating acetaldehyde dehydrogenase: evidence for several active oligomeric states and coenzyme A activation upon binding
Chem. Biol. Interact.
202
70-77
2013
Escherichia coli
Manually annotated by BRENDA team
Smith, N.E.; Vrielink, A.; Attwood, P.V.; Corry, B.
Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study
Biophys. J.
106
1681-1690
2014
Pseudomonas sp. (Q52060), Pseudomonas sp. CF 600 (Q52060)
Manually annotated by BRENDA team
Loder, A.J.; Zeldes, B.M.; Garrison, G.D.; Lipscomb, G.L.; Adams, M.W.; Kelly, R.M.
Alcohol selectivity in a synthetic thermophilic n-butanol pathway is driven by biocatalytic and thermostability characteristics of constituent enzymes
Appl. Environ. Microbiol.
81
7187-7200
2015
Thermoanaerobacter sp. (B0K315), Thermoanaerobacter sp. (B0K4A2)
Manually annotated by BRENDA team
Inokuma, K.; Nakashimada, Y.; Akahoshi, T.; Nishio, N.
Characterization of enzymes involved in the ethanol production of Moorella sp. HUC22-1
Arch. Microbiol.
188
37-45
2007
Moorella sp. HUC22-1
Manually annotated by BRENDA team
Lo, J.; Zheng, T.; Hon, S.; Olson, D.G.; Lynd, L.R.
The bifunctional alcohol and aldehyde dehydrogenase gene, adhE, is necessary for ethanol production in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum
J. Bacteriol.
197
1386-1393
2015
Thermoanaerobacterium saccharolyticum (A0A0H3W5K4), Thermoanaerobacterium saccharolyticum (I3VSF1), Acetivibrio thermocellus (A0A0H3W5U9), Acetivibrio thermocellus (A3DCI2), Thermoanaerobacterium saccharolyticum DSM 8691 (I3VSF1)
Manually annotated by BRENDA team
Krutsakorn, B.; Imagawa, T.; Honda, K.; Okano, K.; Ohtake, H.
Construction of an in vitro bypassed pyruvate decarboxylation pathway using thermostable enzyme modules and its application to N-acetylglutamate production
Microb. Cell Fact.
12
91
2013
Thermus thermophilus (Q53WH9), Thermus thermophilus DSM 579 (Q53WH9)
Manually annotated by BRENDA team
Tsuji, K.; Yoon, K.S.; Ogo, S.
Biochemical characterization of a bifunctional acetaldehyde-alcohol dehydrogenase purified from a facultative anaerobic bacterium Citrobacter sp. S-77
J. Biosci. Bioeng.
121
253-258
2016
Citrobacter sp.
Manually annotated by BRENDA team
Keller, M.W.; Lipscomb, G.L.; Nguyen, D.M.; Crowley, A.T.; Schut, G.J.; Scott, I.; Kelly, R.M.; Adams, M.W.
Ethanol production by the hyperthermophilic archaeon Pyrococcus furiosus by expression of bacterial bifunctional alcohol dehydrogenases
Microb. Biotechnol.
10
1535-1545
2017
Thermoanaerobacter sp. X514 (B0K4A2), Thermoanaerobacter ethanolicus (C7IV28), Thermoanaerobacter ethanolicus JW200 (C7IV28)
Manually annotated by BRENDA team
Atteia, A.; van Lis, R.; Mendoza-Hernández, G.; Henze, K.; Martin, W.; Riveros-Rosas, H.; González-Halphen, D.
Bifunctional aldehyde/alcohol dehydrogenase (ADHE) in chlorophyte algal mitochondria
Plant Mol. Biol.
53
175-188
2003
Polytomella sp. Pringsheim 198.80 (Q70YJ9)
Manually annotated by BRENDA team
Lan, E.; Ro, S.; Liao, J.
Oxygen-tolerant coenzyme A-acylating aldehyde dehydrogenase facilitates efficient photosynthetic n-butanol biosynthesis in cyanobacteria
Energy Environ. Sci.
6
2672-2681
2013
Aeromonas hydrophila
-
Manually annotated by BRENDA team
Tsuji, K.; Yoon, K.S.; Ogo, S.
Biochemical characterization of a bifunctional acetaldehyde-alcohol dehydrogenase purified from a facultative anaerobic bacterium Citrobacter sp. S-77
J. Biosci. Bioeng.
121
253-258
2016
Citrobacter sp. S-77
Manually annotated by BRENDA team
Patil, Y.; Junghare, M.; Müller, N.
Fermentation of glycerol by Anaerobium acetethylicum and its potential use in biofuel production
Microb. Biotechnol.
10
203-217
2017
Anaerobium acetethylicum (A0A1D3TRQ6)
Manually annotated by BRENDA team
Van Lis, R.; Popek, M.; Coute, Y.; Kosta, A.; Drapier, D.; Nitschke, W.; Atteia, A.
Concerted up-regulation of aldehyde/alcohol dehydrogenase (ADHE) and starch in Chlamydomonas reinhardtii increases survival under dark anoxia
J. Biol. Chem.
292
2395-2410
2017
Chlamydomonas reinhardtii (Q1RS84), Chlamydomonas reinhardtii CC-124 (Q1RS84)
Manually annotated by BRENDA team
Pony, P.; Rapisarda, C.; Terradot, L.; Marza, E.; Fronzes, R.
Filamentation of the bacterial bi-functional alcohol/aldehyde dehydrogenase AdhE is essential for substrate channeling and enzymatic regulation
Nat. Commun.
11
1426
2020
Escherichia coli (P0A9Q7)
Manually annotated by BRENDA team