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1.2.1.10: acetaldehyde dehydrogenase (acetylating)

This is an abbreviated version!
For detailed information about acetaldehyde dehydrogenase (acetylating), go to the full flat file.

Word Map on EC 1.2.1.10

Reaction

acetaldehyde
+
CoA
+
NAD+
=
acetyl-CoA
+
NADH
+
H+

Synonyms

4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase, ACDH, acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating], acetaldehyde-alcohol dehydrogenase, acetyl-CoA reductase, acylating acetaldehyde dehydrogenase, AdhE, ADHES77, aldehyde dehydrogenase, aldehyde dehydrogenase (acylating), aldehyde/alcohol dehydrogenase, ALDH, BAD, bi-functional alcohol/aldehyde dehydrogenase, bifunctional acetaldehyde-alcohol dehydrogenase, BphJ, CoA-acylating aldehyde dehydrogenase, CoA-dependent aldehyde dehydrogenase, coenzyme A linked aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, DmpF, DmpFG, MhpF, More, NAD+/CoA-dependent aldehyde dehydrogenase, nonphosphorylating acylating aldehyde dehydrogenase, PduP, Teth514_0627, Teth514_1942, Tsac_0416, TTHB247

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.10 acetaldehyde dehydrogenase (acetylating)

Inhibitors

Inhibitors on EC 1.2.1.10 - acetaldehyde dehydrogenase (acetylating)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetaldehyde
-
competitive inhibition
acetyl-CoA
-
competitive inhibitor with respect to NAD+; competitive to NAD+
ADP
-
1 mM 42% inhibition, competitive to NAD+
ADP-ribose
-
-
AgNO3
-
1 mM 20% inhibition
ATP
-
1 mM 38% inhibition, competitive to NAD+
benzaldehyde
-
-
Ca2+
-
5 mM causes 51% inhibition
Chloroethanol
-
-
CuSO4
-
1 mM 49% inhibition
Disulfiram
-
0.01 mM causes 70% inhibition
HgCl2
-
1 mM 31% inhibition
iodoacetamide
-
1 mM causes 88-96% inhibition
iodoacetate
-
-
Mg2+
-
5 mM causes 51% inhibition
Mn2+
-
5 mM causes 84% inhibition
Na2HAsO4
-
1 mM 100% inhibition, 0.1 mM 32% inhibition
NAD+
-
double competitive, NAD+/CoA ratio is kept at 1:0.24
NADH
-
competitive inhibitor with respect to CoA; competitive to CoA
p-chloromercuribenzoate
-
0.01 mM causes 88-96% inhibition
Tris
-
rate of reaction falls off rapidly in Tris
Valproate
-
50 mM causes 20-46% inhibition
additional information
-
low ionic strength buffers, 0.2 M boric acid/Na2CO3, 0.2 M glycine/NaOH, 0.2 M NH4Cl/NH4OH, pH 8.0, not inhibitory at 1 mM: K+, Na+, Li+, Mg2+, Mn2+, Zn2 +, Ca2+, Fe2+, Fe3+, EDTA, p-chloromercuribenzoate, iodoacetate, N3-, dipyridyl, lactic acid, acetic acid, ethanol, acetylphosphate, pyruvic acid, adenine, adenosine, guanine, guanosine, GMP, GDP, not inhibitory at 0.1 mM: NADP+, NADPH
-