1.18.1.6: adrenodoxin-NADP+ reductase
This is an abbreviated version!
For detailed information about adrenodoxin-NADP+ reductase, go to the full flat file.
Word Map on EC 1.18.1.6
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1.18.1.6
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dioxygenase
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carbazole
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1,9a-dioxygenase
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25-hydroxyvitamin
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cardo
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rieske
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p450scc
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cyp11a1
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rieske-type
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26-hydroxylation
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alpha-triol
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putidaredoxin
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beta-cholestane-3
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ring-hydroxylating
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meta-cleavage
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novosphingobium
- 1.18.1.6
- dioxygenase
- carbazole
-
1,9a-dioxygenase
-
25-hydroxyvitamin
- cardo
-
rieske
- p450scc
- cyp11a1
-
rieske-type
-
26-hydroxylation
-
alpha-triol
- putidaredoxin
-
beta-cholestane-3
-
ring-hydroxylating
-
meta-cleavage
- novosphingobium
Reaction
2 reduced adrenodoxin + + = 2 oxidized adrenodoxin +
Synonyms
AdR, adrenodoxin oxidoreductase, adrenodoxin reductase, ADX reductase, AdxR, FDXR, ferredoxin reductase, FLP, FprA, NADPH adrenodoxin reductase, NADPH-adrenodoxin reductase, NADPH-dependent adrenodoxin reductase, NADPH:adrenal ferredoxin adrenodoxin reductase, NADPH:adrenal ferredoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase mitochondrial, NADPH:adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, TPNH-cytochrome P-450 reductase
ECTree
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General Information
General Information on EC 1.18.1.6 - adrenodoxin-NADP+ reductase
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metabolism
physiological function
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the enzyme functions in the mitochondrial electron transport chain for cytochrome P450-dependent steroid hydroxylation by donating the electrons to adrenodoxin which further transfers them to cytochromes P450scc or P4511beta
metabolism
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the enzyme is the first component in the mitochondrial P450 electron transfer systems. Coexpressed P450, adrenodoxin, and adrenodoxin reductase interact catalytically and allow Escherichia coli to oxidize both cholesterol and vitamin D3
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adrenodoxin reductase is the first enzyme in the mitochondrial P450 systems which catalyzes several critical steps in the biosynthesis of steroid hormones in steroidogenic tissues
physiological function
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the enzyme is an essential component of the electron transport system for the cytochrome P450-dependent hydroxylation
physiological function
the enzyme is involved in the biosynthesis of all steroid hormones