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1.18.1.6: adrenodoxin-NADP+ reductase

This is an abbreviated version!
For detailed information about adrenodoxin-NADP+ reductase, go to the full flat file.

Word Map on EC 1.18.1.6

Reaction

2 reduced adrenodoxin +

NADP+
+
H+
= 2 oxidized adrenodoxin +
NADPH

Synonyms

AdR, adrenodoxin oxidoreductase, adrenodoxin reductase, ADX reductase, AdxR, FDXR, ferredoxin reductase, FLP, FprA, NADPH adrenodoxin reductase, NADPH-adrenodoxin reductase, NADPH-dependent adrenodoxin reductase, NADPH:adrenal ferredoxin adrenodoxin reductase, NADPH:adrenal ferredoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase mitochondrial, NADPH:adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, TPNH-cytochrome P-450 reductase

ECTree

     1 Oxidoreductases
         1.18 Acting on iron-sulfur proteins as donors
             1.18.1 With NAD+ or NADP+ as acceptor
                1.18.1.6 adrenodoxin-NADP+ reductase

Expression

Expression on EC 1.18.1.6 - adrenodoxin-NADP+ reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a SF-1 binding region is located within intron 2 of the human FDXR gene. FDXR transcription is activated through the SF-1 binding site within intron 2. Endogenous SF-1 knockdown in human adrenocortical H295R and KGN cells decreased FDXR expression. In H295R cells, strong binding of two histone markers of active enhancers, histones H3K27ac and H3K4me2, is detected near the SF-1 binding site within intron 2. The binding of these histone markers is decreased concurrent with SF-1 knockdown in H295R cells
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as compared to ovary adrenodoxin reductase concentration increases at least 50fold in corpora lutea
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