1.17.7.4: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase

This is an abbreviated version!
For detailed information about 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase, go to the full flat file.

Word Map on EC 1.17.7.4

1.17.7.4

isoprenoids

dimethylallyl

4-phosphate

methylerythritol

1-hydroxy-2-methyl-2-e-butenyl

2-c-methyl-d-erythritol

dmapp

1-deoxy-d-xylulose

reductoisomerase

1-deoxy-d-xylulose-5-phosphate

e-4-hydroxy-3-methylbut-2-enyl

isoprene

bertoni

rebaudiana

steviol

methyl-jasmonate

synthesis

Reaction

+ 2 oxidized ferredoxin [iron-sulfur] cluster +

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate

+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+

Synonyms

(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1, 4-hydroxy-3-methylbut-2-enyl pyrophosphate reductase, BgHDR1, BgHDR2, chloroplast biogenesis6, Clb6, DsHDR, E-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, EC 1.17.1.2, HDR, HDR1, HMBPP reductase, HsHDR1, HsHDR2, isoprenoid synthesis H, ispH, lysis-tolerant B, LytB, reductase, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate, SrHDR

ECTree

1 Oxidoreductases

1.17 Acting on CH or CH₂ groups

1.17.7 With an iron-sulfur protein as acceptor

1.17.7.4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase

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Results	in table
33646	AA Sequence
1	Application
1	CAS Registry Number
16	Cloned(Commentary)
12	Cofactor
2	Crystallization (Commentary)
6	Expression
17	General Information
1	General Stability
4	IC50 Value
26	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
4	KM Value [mM]
8	Localization
14	Metals/Ions
8	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
33	Organism
2	Oxidation Stability
7	Pathway
3	pH Optimum
3	pI Value
11	Protein Variants
8	Purification (Commentary)
8	Reaction
3	Reaction Type
32	Reference
1	Renatured (Commentary)
20	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
54	Substrates and Products (Substrate)
9	Subunits
70	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.17.7.4 - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase

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isopentenyl-diphosphate:ferredoxin oxidoreductase

An iron-sulfur protein that contains either a [3Fe-4S] [6] or a [4Fe-4S] [5] cluster. This enzyme forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of 3-methylbut-3-en-1-yl diphosphate and prenyl diphosphate.