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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
dimethylallyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
additional information
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production of isopentenyl diphosphate and dimethylallyl diphosphate is key step in controlling the production of plastidial isoprenoid precursors and carotenoid biosynthesis in plant cells
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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r
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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-
r
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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r
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
dimethylallyl diphosphate + NAD(P)+ + H2O
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formation of a mixture of isopentenyl diphosphate and dimethylallyl diphosphate in a ratio 1:5
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
dimethylallyl diphosphate + NAD(P)+ + H2O
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HMBPP reductase catalyzes the 2H+/2e- reduction of (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate to form an approximately 5:1 mixture of isopentenyl diphosphate and dimethylallyl diphosphate, insights into IspH catalysis and inhibition, involving organometallic species. Residue E126 is essential for catalytic activity. Residue H124 is not a major contributor to substrate binding, but is essential for catalysis, it is involved in delivering H+ to E126 and the bound (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate. Residue H42 forms hydrogen bonds to the bound diphosphate ligand. Ligand binding structure spectral analysis and modelling, overview
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
dimethylallyl diphosphate + NAD(P)+ + H2O
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in the nonmevalonate pathway, the terminal intermediate, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, i.e. HMBPP, is reductively converted into a mixture of isopentenyl diphosphate and dimethylallyl diphosphate
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
isopentenyl diphosphate + NAD(P)+ + H2O
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formation of a mixture of isopentenyl diphosphate and dimethylallyl diphosphate in a ratio 1:5
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r
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
isopentenyl diphosphate + NAD(P)+ + H2O
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HMBPP reductase catalyzes the 2H+/2e- reduction of (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate to form an approximately 5:1 mixture of isopentenyl diphosphate and dimethylallyl diphosphate, insights into IspH catalysis and inhibition, involving organometallic species. Residue E126 is essential for catalytic activity. Residue H124 is not a major contributor to substrate binding, but is essential for catalysis, it is involved in delivering H+ to E126 and the bound (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate. Residue H42 forms hydrogen bonds to the bound diphosphate ligand. Ligand binding structure spectral analysis and modelling, overview
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r
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
isopentenyl diphosphate + NAD(P)+ + H2O
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in the nonmevalonate pathway, the terminal intermediate, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, i.e. HMBPP, is reductively converted into a mixture of isopentenyl diphosphate and dimethylallyl diphosphate
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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-
-
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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-
-
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
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isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
part of isoprenoid biosynthesis
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
2-C-methyl-D-erithritol-4-phosphate pathway
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
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part of isoprenoid biosynthesis
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
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biosynthesis of terpenes
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
biosynthesis of terpenes
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
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2-C-methyl-D-erithritol-4-phosphate pathway
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
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2-C-methyl-D-erithritol-4-phosphate pathway
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
investigation of biosynthetic coupling and pattern by expression of involved genes from synthetic operon
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r
isopentenyl diphosphate + NAD(P)+ + H2O
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
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2-C-methyl-D-erithritol-4-phosphate pathway
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r