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1.17.7.3: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

This is an abbreviated version!
For detailed information about (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin), go to the full flat file.

Word Map on EC 1.17.7.3

Reaction

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
+
H2O
 +
oxidized flavodoxin
=
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
 +
reduced flavodoxin

Synonyms

(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating), (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate reductase, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, GcpE, HMBPP synthase, IspG

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.7 With an iron-sulfur protein as acceptor
                1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

Reference

topprint

Reference on EC 1.17.7.3 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hecht, S.; Eisenreich, W.; Adam, P.; Amslinger, S.; Kis, K.; Bacher, A.; Arigoni, D.; Rohdich, F.
Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein
Proc. Natl. Acad. Sci. USA
98
14837-14842
2001
Escherichia coli (P62620)
Manually annotated by BRENDA team
Rohdich, F.; Zepeck, F.; Adam, P.; Hecht, S.; Kaiser, J.; Laupitz, R.; Grawert, T.; Amslinger, S.; Eisenreich, W.; Bacher, A.; Arigoni, D.
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and isph protein
Proc. Natl. Acad. Sci. USA
100
1586-1591
2003
Escherichia coli (P62620)
Manually annotated by BRENDA team
Zepeck, F.; Graewert, T.; Kaiser, J.; Schramek, N.; Eisenreich, W.; Bacher, A.; Rohdich, F.
Biosynthesis of isoprenoids. Purification and properties of IspG protein from Escherichia coli
J. Org. Chem.
70
9168-9174
2005
Escherichia coli (P62620)
Manually annotated by BRENDA team
Seemann, M.; Tse Sum Bui, B.; Wolff, M.; Tritsch, D.; Campos, N.; Boronat, A.; Marquet, A.; Rohmer, M.
Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein
Angew. Chem. Int. Ed. Engl.
41
4337-4339
2002
Escherichia coli (P62620)
Manually annotated by BRENDA team
Puan, K.; Wang, H.; Dairi, T.; Kuzuyama, T.; Morita, C.
fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis
FEBS Lett.
579
3802-3806
2005
Escherichia coli (P62620)
Manually annotated by BRENDA team
Wang, W.; Oldfield, E.
Bioorganometallic chemistry with IspG and IspH Structure, function, and inhibition of the [Fe4S4] proteins involved in isoprenoid biosynthesis
Angew. Chem. Int. Ed. Engl.
53
4294-4310
2014
Thermus thermophilus (Q72H18)
Manually annotated by BRENDA team
Guerra, F.; Wang, K.; Li, J.; Wang, W.; Liu, Y.; Amin, S.; Oldfield, E.
Inhibition of the 4Fe-4S proteins IspG and IspH An EPR, ENDOR and HYSCORE investigation
Chem. Sci.
5
1642-1649
2014
Escherichia coli
Manually annotated by BRENDA team
Zhou, J.; Yang, L.; Wang, C.; Choi, E.; Kim, S.
Enhanced performance of the methylerythritol phosphate pathway by manipulation of redox reactions relevant to IspC, IspG, and IspH
J. Biotechnol.
248
1-8
2017
Escherichia coli (P62620)
Manually annotated by BRENDA team
Li, Q.; Fan, F.; Gao, X.; Yang, C.; Bi, C.; Tang, J.; Liu, T.; Zhang, X.
Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli
Metab. Eng.
44
13-21
2017
Escherichia coli, Escherichia coli CAR005
Manually annotated by BRENDA team