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1.17.7.3: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

This is an abbreviated version!
For detailed information about (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin), go to the full flat file.

Word Map on EC 1.17.7.3

Reaction

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
+
H2O
 +
oxidized flavodoxin
=
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
 +
reduced flavodoxin

Synonyms

(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating), (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate reductase, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, GcpE, HMBPP synthase, IspG

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.7 With an iron-sulfur protein as acceptor
                1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

Inhibitors

Inhibitors on EC 1.17.7.3 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2Z)-3-methyl-4-sulfanylbut-2-en-1-yl trihydrogen diphosphate
-
-
(2Z)-4-amino-3-methylbut-2-en-1-yl trihydrogen diphosphate
-
-
aminosulfonylcarbamate
weak inhibitor
but-3-yn-1-yl trihydrogen diphosphate
-
-
Ca2+
1 mM, 43% inhibition
Co2+
1 mM, 29% inhibition
EDTA
10 mM, complete inhibition, reactivated by Mn2+ to a level of 25%
Fe2+
1 mM, 11% inhibition
Mg2+
1 mM, 25% inhibition
N-acyl-N'-oxysulfamate
weak inhibitor
-
Ni2+
1 mM, 30% inhibition
prop-2-yn-1-yl trihydrogen diphosphate
Zn2+
1 mM, 98% inhibition