1.17.5.1: phenylacetyl-CoA dehydrogenase
This is an abbreviated version!
For detailed information about phenylacetyl-CoA dehydrogenase, go to the full flat file.
Reaction
Synonyms
More, oxidase, phenylacetyl coenzyme A (alpha-oxidizing), phenylacetyl-CoA alpha-carbon-oxidizing oxidase, phenylacetyl-CoA-acceptor oxidoreductase, phenylacetyl-CoA:acceptor oxidoreductase
ECTree
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Reaction
Reaction on EC 1.17.5.1 - phenylacetyl-CoA dehydrogenase
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phenylacetyl-CoA + H2O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol
the enzyme from Thauera aromatica is a membrane-bound molybdenum-iron-sulfur protein, the enzyme is specific for phenylacetyl-CoA as substrate, phenylacetate, acetyl-CoA, benzoyl-CoA, propionyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates, the oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen, duroquinone, menaquinone and 2,6-dichlorophenolindophenol(DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone, a second enzyme, EC 3.1.2.25, phenylglyoxylyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate
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