1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.

Word Map on EC 1.17.4.5

1.17.4.5

anticoagulant

coagulation

k-dependent

carboxylase

non-hepatic

4-hydroxycoumarins

dosing

warfarin-resistant

vkorc1

2,3-epoxide

clotting

s-warfarin

pharmacogenetic

dithiothreitol-dependent

scottish

rodenticide

Reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone

2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone

Synonyms

EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1

ECTree

1 Oxidoreductases

1.17 Acting on CH or CH₂ groups

1.17.4 With a disulfide as acceptor

1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

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Substrates Products on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)

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2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol

Bos taurus

287714

2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol

Bos taurus

i.e. vitamin K 2,3-epoxide

287714

i.e. 3-hydroxy-2,3-dihydro-vitamin K

287714

2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O

2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

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