1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)
This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.
Word Map on EC 1.17.4.5
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1.17.4.5
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anticoagulant
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coagulation
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k-dependent
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carboxylase
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non-hepatic
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4-hydroxycoumarins
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dosing
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warfarin-resistant
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vkorc1
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2,3-epoxide
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clotting
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s-warfarin
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pharmacogenetic
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dithiothreitol-dependent
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scottish
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rodenticide
- 1.17.4.5
-
anticoagulant
-
coagulation
-
k-dependent
- carboxylase
-
non-hepatic
- 4-hydroxycoumarins
-
dosing
-
warfarin-resistant
- vkorc1
- 2,3-epoxide
-
clotting
-
s-warfarin
-
pharmacogenetic
-
dithiothreitol-dependent
-
scottish
-
rodenticide
Reaction
Synonyms
EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1
ECTree
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Engineering
Engineering on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)
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L128R
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the naturally occuring mutant shows significantly increased warfarin resistance, but its enzyme activity is 2fold higher compared to wild-type VKOR
W59L
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the naturally occuring mutant shows significantly increased warfarin resistance, but its enzyme activity is 2fold higher compared to wild-type VKOR
W59R
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the naturally occuring mutant shows significantly increased warfarin resistance, but its enzyme activity is similar to wild-type VKOR
additional information
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knockout of endogenous VKOR activity, i.e. VKOR and VKORC1L1 enzymes, in HEK-293 cells by transcription activator-like effector nucleases (TALENs)-mediated genome editing, overview
additional information
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the W59R mutant has lower activity but higher warfarin resistance than the W59L mutant, warfarin resistance evaluation of the naturally occurring VKOR mutants, overview