1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)
This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.
Word Map on EC 1.17.4.2
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1.17.4.2
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hydroxyurea
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deoxyribonucleotides
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dntp
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rr
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herpes
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tyrosyl
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simplex
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gemcitabine
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leukemia
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reductases
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thymidine
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thioredoxins
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deoxycytidine
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deoxynucleotides
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cdp
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s-phase
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thymidylate
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thiosemicarbazone
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glutaredoxins
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checkpoint
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nsclc
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cytidine
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diferric
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deoxyadenosine
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diiron
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fork
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deoxyguanosine
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5'-diphosphate
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nonidentical
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gallium
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antiferromagnetically
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hyperfine
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proton-coupled
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dinuclear
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oncolytic
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cross-complementation
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acyclovir
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cladribine
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chk1
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thiyl
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aphidicolin
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cross-complementing
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endor
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fludarabine
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b12-dependent
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gemcitabine-based
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deoxythymidine
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analysis
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gemcitabine-induced
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high-valent
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peroxo
- 1.17.4.2
- hydroxyurea
- deoxyribonucleotides
- dntp
- rr
- herpes
-
tyrosyl
- simplex
- gemcitabine
- leukemia
- reductases
- thymidine
- thioredoxins
- deoxycytidine
-
deoxynucleotides
- cdp
-
s-phase
- thymidylate
- thiosemicarbazone
- glutaredoxins
-
checkpoint
-
nsclc
- cytidine
-
diferric
- deoxyadenosine
-
diiron
-
fork
- deoxyguanosine
- 5'-diphosphate
-
nonidentical
- gallium
-
antiferromagnetically
-
hyperfine
-
proton-coupled
-
dinuclear
-
oncolytic
-
cross-complementation
- acyclovir
- cladribine
- chk1
-
thiyl
- aphidicolin
-
cross-complementing
-
endor
- fludarabine
-
b12-dependent
-
gemcitabine-based
- deoxythymidine
- analysis
-
gemcitabine-induced
-
high-valent
-
peroxo
Reaction
Synonyms
2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR
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Subunits
Subunits on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)
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dimer
monomer
monomer or dimer
tetramer
additional information
tetramer
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alpha2beta2 heterodimer with a regulatory, nucleotide binding site M1 subunit, and an inducible, catalytic M2 subunit which contains non-heme iron and a tyrosyl free radical, that are required for the enzymatic reduction of ribonucleotides
tetramer
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RNR is a tetramer consisting of two non-identical homodimers. The two identical M2 subunits regulate the substrate specificity of the enzyme, while the other two identical M1 subunits are responsible for the activity by binding the ribonucleotides and allosteric effectors
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structure comparisons of classI-III RNRs, model for the subunit organization of RNRs, overview
additional information
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structures of the active holoenzymes of class I-III RNRs, structure comparisons, overview
additional information
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structure comparisons of classI-III RNRs, model for the subunit organization of RNRs, overview
additional information
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the enzyme is encoded by two consecutive open reading frames denated nrdJa and nrdJb and separated by 16 bp. The presence of both NrdJa and NrdJb subunits is absolutely essential for enzyme activity
additional information
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structures of the active holoenzymes of class I-III RNRs, structure comparisons, overview
additional information
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structures of the active holoenzymes of class I-III RNRs, structure comparisons, overview
additional information
Tequatrovirus T4
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structure comparisons of classI-III RNRs, model for the subunit organization of RNRs, overview