1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)
This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.
Word Map on EC 1.17.4.2
-
1.17.4.2
-
hydroxyurea
-
deoxyribonucleotides
-
dntp
-
rr
-
herpes
-
tyrosyl
-
simplex
-
gemcitabine
-
leukemia
-
reductases
-
thymidine
-
thioredoxins
-
deoxycytidine
-
deoxynucleotides
-
cdp
-
s-phase
-
thymidylate
-
thiosemicarbazone
-
glutaredoxins
-
checkpoint
-
nsclc
-
cytidine
-
diferric
-
deoxyadenosine
-
diiron
-
fork
-
deoxyguanosine
-
5'-diphosphate
-
nonidentical
-
gallium
-
antiferromagnetically
-
hyperfine
-
proton-coupled
-
dinuclear
-
oncolytic
-
cross-complementation
-
acyclovir
-
cladribine
-
chk1
-
thiyl
-
aphidicolin
-
cross-complementing
-
endor
-
fludarabine
-
b12-dependent
-
gemcitabine-based
-
deoxythymidine
-
analysis
-
gemcitabine-induced
-
high-valent
-
peroxo
- 1.17.4.2
- hydroxyurea
- deoxyribonucleotides
- dntp
- rr
- herpes
-
tyrosyl
- simplex
- gemcitabine
- leukemia
- reductases
- thymidine
- thioredoxins
- deoxycytidine
-
deoxynucleotides
- cdp
-
s-phase
- thymidylate
- thiosemicarbazone
- glutaredoxins
-
checkpoint
-
nsclc
- cytidine
-
diferric
- deoxyadenosine
-
diiron
-
fork
- deoxyguanosine
- 5'-diphosphate
-
nonidentical
- gallium
-
antiferromagnetically
-
hyperfine
-
proton-coupled
-
dinuclear
-
oncolytic
-
cross-complementation
- acyclovir
- cladribine
- chk1
-
thiyl
- aphidicolin
-
cross-complementing
-
endor
- fludarabine
-
b12-dependent
-
gemcitabine-based
- deoxythymidine
- analysis
-
gemcitabine-induced
-
high-valent
-
peroxo
Reaction
Synonyms
2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR
ECTree
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + reduced thioredoxin
-
-
-
-
r
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + thioredoxin
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O
-
-
-
-
?
nucleoside 5'-triphosphate + formate
2'-deoxynucleoside 5'-triphosphate + H2O
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + formate
2'-deoxynucleoside 5'-triphosphate + H2O
Tequatrovirus T4
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class II RNRs
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class II RNRs
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class III RNR
-
-
?
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Astasia sp.
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
key enzyme in the pathway of DNA biosynthesis in all organisms
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
437887, 437889, 437890, 437891, 437892, 437893, 437894, 437896, 437897, 437898, 437899, 437901, 437902, 437903
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
physiological hydrogen donor is unknown
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
catalyzes the rate-determining step in DNA biosynthesis
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
-
class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'-deoxy products, overview
-
-
?
additional information
?
-
-
the anaerobic ribonucleotide reductase of Escherichia coli is an essential enzyme required to supply the building blocks for DNA synthesis
-
-
?
additional information
?
-
-
p53-dependent small enzyme subunit M2B may play an important role for initiating DNA replication in normal growth
-
-
?
additional information
?
-
-
the enzyme produces deoxyribonucleotide triphosphates, dNTPs
-
-
?
additional information
?
-
-
RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides requiring adenosylcobalamin as a cofactor, model of reaction mechanism, overview
-
-
?
additional information
?
-
-
RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor
-
-
?
additional information
?
-
-
class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'deoxy products, overview
-
-
?
additional information
?
-
-
the two-component class II RNR is primarily used for DNA repair and/or possibly DNA replication at low oxygen tension. It can support bacterial growth in the absence of class I RNR activity
-
-
?
