1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)

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For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.17.4.2

1.17.4.2

hydroxyurea

deoxyribonucleotides

dntp

rr

herpes

tyrosyl

simplex

gemcitabine

leukemia

reductases

thymidine

thioredoxins

deoxycytidine

deoxynucleotides

cdp

s-phase

thymidylate

thiosemicarbazone

glutaredoxins

checkpoint

nsclc

cytidine

diferric

deoxyadenosine

diiron

fork

deoxyguanosine

5'-diphosphate

nonidentical

gallium

antiferromagnetically

hyperfine

proton-coupled

dinuclear

oncolytic

cross-complementation

acyclovir

cladribine

chk1

thiyl

aphidicolin

cross-complementing

endor

fludarabine

b12-dependent

gemcitabine-based

deoxythymidine

analysis

gemcitabine-induced

high-valent

peroxo

Reaction

Synonyms

2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR

ECTree

1 Oxidoreductases

1.17 Acting on CH or CH₂ groups

1.17.4 With a disulfide as acceptor

1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)

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Results	in table
57	Activating Compound
12765	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
51	Cofactor
4	Crystallization (Commentary)
3255	Disease/ Diagnostics
1	Expression
18	General Information
2	General Stability
55	Inhibitors
9	Ki Value [mM]
28	KM Value [mM]
6	Localization
25	Metals/Ions
26	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
226	Organism
5	Pathway
21	PDB ID
5	pH Optimum
1	pH Range
20	Protein Variants
17	Purification (Commentary)
1	Reaction
1	Reaction Type
114	Reference
29	Source Tissue
6	Specific Activity [micromol/min/mg]
6	Storage Stability
285	Substrates and Products (Substrate)
28	Subunits
54	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Turnover Number [1/s]

Expression

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Expression on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)

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endogenous RNR transcripts are downregulated in response to large increases of mtDNA in mice, which is indicative of nuclear-mitochondrial crosstalk with regard to mtDNA copy number

Mus musculus

716377