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1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Word Map on EC 1.17.4.1

Reaction

2'-deoxyribonucleoside 5'-diphosphate
+
thioredoxin disulfide
+
H2O
=
ribonucleoside 5'-diphosphate
+
thioredoxin

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.1 ribonucleoside-diphosphate reductase

Oxidation Stability

Oxidation Stability on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
in hypoxic conditions the small subunit of the ribonucleotide reductase enzyme is switched from RRM2 to RRM2B in order to facilitate nucleotide production and ongoing replication. Specific residues within RRM2B are identified that are responsible for maintaining activity in hypoxia. RRM2B retains activity in hypoxic conditions and is the favored ribonucleotide reductase subunit in hypoxia. Loss of RRM2B has detrimental consequences for cell fate, specifically in hypoxia
745759
the enzyme is not stable to to reactive oxygen and nitrogen species, RO(N)S, produced by the host’s immune system
-
685235