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1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Word Map on EC 1.17.4.1

Reaction

2'-deoxyribonucleoside 5'-diphosphate
+
thioredoxin disulfide
+
H2O
=
ribonucleoside 5'-diphosphate
+
thioredoxin

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.1 ribonucleoside-diphosphate reductase

KI Value

KI Value on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.023
2'-deoxy-2'-azidocytidine diphosphate
-
-
0.0037 - 0.0079
2'-methyladenosine 5'-diphosphate
0.084 - 0.115
2'-methyluridine 5'-diphosphate
1.1 - 1.5
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
0.4
5'-O-valproyl-3'-C-methyladenosine
pH and temperature not specified in the publication
-
0.0055 - 0.036
ADP
0.00042 - 0.0019
CDP
0.00004
clofarabine
-
pH not specified in the publication, temperature not specified in the publication
0.0002 - 0.0006
dATP
0.0004 - 0.0018
dGTP
0.0006 - 0.007
GDP
14 - 27
guanozole
0.69
Hydroxyurea
-
-
1
L-ADP
-
-
0.02
N-alpha-acetyl-FTLDADF
-
N-alpha-acetyl heptapeptide, identical to the last seven amino acids of R2 subunit C-terminus from mouse enzyme
0.0058 - 0.5
UDP
additional information
additional information
-
inhibition kinetics of clofarabine di- and triphosphates, overview
-