1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Reaction

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.4 With a disulfide as acceptor

                1.17.4.1 ribonucleoside-diphosphate reductase

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Results	in table
306	Activating Compound
93601	AA Sequence
18	Application
1	CAS Registry Number
42	Cloned(Commentary)
61	Cofactor
22	Crystallization (Commentary)
147	Disease/ Diagnostics
9	Expression
47	General Information
6	General Stability
27	IC50 Value
482	Inhibitors
40	Ki Value [mM]
40	KM Value [mM]
14	Localization
120	Metals/Ions
52	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
248	Organism
2	Oxidation Stability
18	Pathway
527	PDB ID
18	pH Optimum
2	pH Range
67	Protein Variants
47	Purification (Commentary)
26	Reaction
3	Reaction Type
237	Reference
87	Source Tissue
49	Specific Activity [micromol/min/mg]
10	Storage Stability
277	Substrates and Products (Substrate)
110	Subunits
155	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.011

(2E)-2-(anthracen-9-ylmethylidene)-N-hydroxyhydrazinecarboximidamide

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

726918

0.5

2-furan-3-ylbenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

2-furan-3-ylbenzaldehyde N-phenylthiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

2-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

2-hydroxybenzaldehyde N-phenylthiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

2-thiophen-2-ylbenzaldehyde N-(4-chlorophenyl)thiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

2-thiophen-2-ylbenzaldehyde N-phenylthiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

4-hydroxy-3-methoxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.5

4-hydroxy-3-methoxybenzaldehyde N-phenylthiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.047

4-hydroxybenzaldehyde N-(2-chlorophenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.029

4-hydroxybenzaldehyde N-(2-hydroxyphenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.042

4-hydroxybenzaldehyde N-(2-methoxyphenyl)thiosemicarbazone

Homo sapiens

-

above, pH 7.2, 37°C

702551

0.037

4-hydroxybenzaldehyde N-(2-methylphenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.039

4-hydroxybenzaldehyde N-(2-nitrophenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.029

4-hydroxybenzaldehyde N-(3-chlorophenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.029

4-hydroxybenzaldehyde N-(3-hydroxyphenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.03

4-hydroxybenzaldehyde N-(3-methylphenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.287

4-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.043

4-hydroxybenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.014

4-hydroxybenzaldehyde N-(4-methylphenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.045

4-hydroxybenzaldehyde N-(4-nitrophenyl)thiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.242

4-hydroxybenzaldehyde N-phenylthiosemicarbazone

Homo sapiens

-

pH 7.2, 37°C

702551

0.5

4-methoxyphenol

Corynebacterium glutamicum

-

-

703813

2.4

EDTA

Corynebacterium glutamicum

-

-

703813

1.7

Hydroxyurea

Corynebacterium glutamicum

-

-

703813

0.0026

peptide Fmoc-P6

Saccharomyces cerevisiae

P21524

yeast enzyme

688286

-

0.031

peptide P7

Saccharomyces cerevisiae

P21524

yeast enzyme

688286

-