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1.17.3.2: xanthine oxidase

This is an abbreviated version!
For detailed information about xanthine oxidase, go to the full flat file.

Word Map on EC 1.17.3.2

Reaction

xanthine
+
H2O
+
O2
=
Urate
+
H2O2

Synonyms

AXOR, EC 1.1.3.22, EC 1.2.3.2, EC 1.2.3.2., hypoxanthine oxidase, hypoxanthine-xanthine oxidase, hypoxanthine:oxygen oxidoreductase, More, oxidase, xanthine, Schardinger enzyme, xanthine dehydrogenase/oxidase, xanthine oxidase, xanthine oxidoreductase, xanthine: oxygen oxidoreductase, xanthine:O2 oxidoreductase, xanthine:oxygen oxidoreductase, xanthine:xanthine oxidase, XnOx, XO, XOD, XOR

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.3 With oxygen as acceptor
                1.17.3.2 xanthine oxidase

Activating Compound

Activating Compound on EC 1.17.3.2 - xanthine oxidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetonitrile
-
-
allopurinol
-
inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview
angiotensin II
-
Ang II substantially increases endothelial enzyme protein levels and enzyme-dependent superoxide production in cultured endothelial cells
apigenin
-
increases liver xanthine oxidase activities significantly, but has no effect on serum xanthine oxidase activities
apoptotic lymphocyte microparticles
-
microparticles are membrane vesicles released during cell activation and apoptosis, they activate reactive oxygen species production by xanthine oxidase in endothelial cells and aorta, inhibition of phosphoinositol 3-kinase enhances the activating effect, xanthine oxidase inhibitors reduce it, overview
-
ascorbate
-
in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction
astilbin
-
significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly
dimethylformamide
-
highly stimulating
dioxane
-
-
diphenylene iodonium chloride
-
strongly inhibits xanthine oxidase mediated NO generation with NADH serving as reducing substrate, with xanthine or 2,3-dihydroxybenzaldehyde as reducing substrates, NO generation is increased more than six times
dithiothreitol
-
enhance oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
ethanol
-
-
glutathione
-
enhances oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
L-cysteine
-
in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction
methanol
-
slightly stimulating
N-acetyl-L-Cys
-
enhance oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
potassium oxonate
-
slight activation in vivo
Propanol
-
slightly stimulating
quercetin
-
significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly
rutin
-
significantly increases serum xanthine oxidase activities
sulfide/dithionite
-
treatment increases the specific activity of AtXDH1
-
tetrahydrofuran
-
-
Th-1 cytokine
-
increases XOR activity in inflammatory mononuclear phagocytes in vivo
-
thiol
-
in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction
additional information
-