1.17.3.2: xanthine oxidase
This is an abbreviated version!
For detailed information about xanthine oxidase, go to the full flat file.
Word Map on EC 1.17.3.2
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1.17.3.2
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allopurinol
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uric
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dismutase
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catalase
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sod
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xx
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endothelial
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malondialdehyde
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hyperuricemia
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reperfusion
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gout
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ischemia
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purine
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artery
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karyotype
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turner
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myocardial
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gsh
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pulmonary
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myeloperoxidase
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ischemia-reperfusion
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gonad
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hermaphrodite
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oxypurinol
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thiobarbituric
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urate
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spin
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tbars
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chemiluminescence
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dysgenesis
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molybdenum
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gsh-px
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sex-determining
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caffeine
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x-chromosome
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oxygen-derived
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tungsten
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acid-reactive
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masculinization
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fenton
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sex-reversed
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hypouricemic
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monosomy
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feminization
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drug development
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diagnostics
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urate-lowering
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synthesis
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self-fertilizing
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biotechnology
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medicine
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radical-generating
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cyp2a6
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oxidase-derived
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pharmacology
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nondisjunction
- 1.17.3.2
- allopurinol
-
uric
- dismutase
- catalase
- sod
- xx
- endothelial
- malondialdehyde
-
hyperuricemia
-
reperfusion
- gout
- ischemia
- purine
- artery
- karyotype
-
turner
- myocardial
- gsh
- pulmonary
- myeloperoxidase
-
ischemia-reperfusion
- gonad
-
hermaphrodite
- oxypurinol
-
thiobarbituric
- urate
-
spin
-
tbars
-
chemiluminescence
- dysgenesis
- molybdenum
- gsh-px
-
sex-determining
- caffeine
-
x-chromosome
-
oxygen-derived
- tungsten
-
acid-reactive
-
masculinization
-
fenton
-
sex-reversed
-
hypouricemic
-
monosomy
-
feminization
- drug development
- diagnostics
-
urate-lowering
- synthesis
-
self-fertilizing
- biotechnology
- medicine
-
radical-generating
- cyp2a6
-
oxidase-derived
- pharmacology
-
nondisjunction
Reaction
Synonyms
AXOR, EC 1.1.3.22, EC 1.2.3.2, EC 1.2.3.2., hypoxanthine oxidase, hypoxanthine-xanthine oxidase, hypoxanthine:oxygen oxidoreductase, More, oxidase, xanthine, Schardinger enzyme, xanthine dehydrogenase/oxidase, xanthine oxidase, xanthine oxidoreductase, xanthine: oxygen oxidoreductase, xanthine:O2 oxidoreductase, xanthine:oxygen oxidoreductase, xanthine:xanthine oxidase, XnOx, XO, XOD, XOR
ECTree
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Activating Compound
Activating Compound on EC 1.17.3.2 - xanthine oxidase
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allopurinol
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inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview
angiotensin II
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Ang II substantially increases endothelial enzyme protein levels and enzyme-dependent superoxide production in cultured endothelial cells
apigenin
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increases liver xanthine oxidase activities significantly, but has no effect on serum xanthine oxidase activities
apoptotic lymphocyte microparticles
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microparticles are membrane vesicles released during cell activation and apoptosis, they activate reactive oxygen species production by xanthine oxidase in endothelial cells and aorta, inhibition of phosphoinositol 3-kinase enhances the activating effect, xanthine oxidase inhibitors reduce it, overview
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ascorbate
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in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction
astilbin
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significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly
diphenylene iodonium chloride
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strongly inhibits xanthine oxidase mediated NO generation with NADH serving as reducing substrate, with xanthine or 2,3-dihydroxybenzaldehyde as reducing substrates, NO generation is increased more than six times
dithiothreitol
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enhance oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
glutathione
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enhances oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
L-cysteine
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in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction
N-acetyl-L-Cys
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enhance oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system
quercetin
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significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly
sulfide/dithionite
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treatment increases the specific activity of AtXDH1
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Th-1 cytokine
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increases XOR activity in inflammatory mononuclear phagocytes in vivo
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thiol
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in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction
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study on the effect of food extracts on enzyme activity in vitro. Orange juice and pink grapefruit juice are activating
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additional information
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bacterial infection of mammary gland induces the enzyme in milk, while enzyme activity in milk is not affected by bacteria, overview
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additional information
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the enzyme activity is stimulated by organic solvents, but the effect is reduced with increasing temperature, from 27°C to 37°C, the inhibitory effects of all organic solvents on the enzyme activity are increased at higher temperature
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additional information
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colon obstruction induces a hyperdynamic circulatory reaction, significantly elevated the motility index and increased mucosal leucocyte accumulation and XOR activity, the increase in activity is counteracted by kynurenic acid
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additional information
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heat shock, e.g. by infrared light, induces the enzyme and reactive oxygen species production in keratinocytes and skin, overview
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additional information
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experimental sepsis induces the enzyme in the intestine
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additional information
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liver injury due to treatment with D-galactosamine imduces the hepatic enzyme expression
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additional information
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XOR activity is specifically increased by inflammatory mononuclear phagocyte differentiation
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