1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase
This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate reductase, go to the full flat file.
Word Map on EC 1.17.1.8
-
1.17.1.8
-
diaminopimelate
-
glutamicum
-
meso-diaminopimelate
-
aspartokinase
-
imine
-
dhdps
-
2,6-pyridinedicarboxylate
-
medicine
-
alpha,beta-unsaturated
-
2'-phosphate
-
s-2-aminoethyl-l-cysteine
-
aspartate-semialdehyde
-
drug development
-
agriculture
- 1.17.1.8
- diaminopimelate
- glutamicum
- meso-diaminopimelate
- aspartokinase
- imine
- dhdps
- 2,6-pyridinedicarboxylate
- medicine
-
alpha,beta-unsaturated
-
2'-phosphate
- s-2-aminoethyl-l-cysteine
-
aspartate-semialdehyde
- drug development
- agriculture
Reaction
Synonyms
AbDHDPR, CRR1, DapB, DHDP reductase, DHDPR, DHPR, dihydrodipicolinate reductase, dihydrodipicolinate reductase-like protein, dihydrodipicolinic acid reductase, EC 1.3.1.26, MRSA-DHDPR, reductase, dihydrodipicolinate
ECTree
1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.17.1.8 - 4-hydroxy-tetrahydrodipicolinate reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
dihydrodipicolinate + NADH + H+
tetrahydrodipicolinate + NAD+
-
substrate dihydrodipicolinate is instable
-
-
?
additional information
?
-
-
DHDPR accepts (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid as true substrate rather than dihydrodipicolinate, suggesting that DHDPR catalyzes an overall deoxygenation reaction, likely by a dehydratase-reductase route, substrate specificity, overview. A critical role is played by residue His 159 in the catalytic mechanism of DHDPR. Replacement of this residue with an alanine or a glutamine is reported to result in a 150-200fold reduction in catalytic rate as well as a 6fold increase in KM. His 159 has been proposed to act as a general acid during catalysis, providing the proton required after hydride addition. No activity with beta-hydroxypyruvate and 3-fluoropyruvate
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme is involved in L-lysine biosynthesis
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme is involved in L-lysine biosynthesis
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants
-
-
?
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants
-
-
?
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
involved in L-lysine biosynthesis
-
-
?
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
involved in L-lysine biosynthesis
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
highest activity during exponential growth phase
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
no regulatory effect of lysine
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
ir
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
lysine and diaminopimelate biosynthesis pathway
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
lysine and diaminopimelate biosynthesis pathway
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
determination of metabolic block in the pathway in mutant M-203
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
enzyme is a part of the biosynthetic pathway leading to meso-diaminopimelic acid and L-lysine in bacteria and higher plants
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
highest activity during exponential growth phase
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
repressed by lysine
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
essentially involved in cell wall synthesis
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
second step in the biosynthesis of meso-diaminopimelate, a bacterial cell wall component, and is involved in L-lysine biosynthesis
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
second step in the biosynthesis of meso-diaminopimelate, a bacterial cell wall component, and is involved in L-lysine biosynthesis
-
-
?
2,3-dihydrodipicolinate + NAD(P)H
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
-
-
-
?
