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1.17.1.5: nicotinate dehydrogenase

This is an abbreviated version!
For detailed information about nicotinate dehydrogenase, go to the full flat file.

Word Map on EC 1.17.1.5

Reaction

nicotinate
+
H2O
+
NADP+
=
6-Hydroxynicotinate
+
NADPH
+
H+

Synonyms

dehydrogenase, nicotinate, EC 1.5.1.13, NA hydroxylase, NAH, NahAB1B2, NDH, NdhL, NdhM, NdhS, nicotinate dehydrogenase, nicotinic acid hydroxylase, three-component NA hydroxylase, three-component nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.1 With NAD+ or NADP+ as acceptor
                1.17.1.5 nicotinate dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.17.1.5 - nicotinate dehydrogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-cyanopyridine + H2O + NADP+
6-hydroxy-3-cyanopyridine + NADPH + H+
show the reaction diagram
nicotinate + H2O + electron acceptor
6-hydroxynicotinate + reduced electron acceptor
show the reaction diagram
nicotinate + H2O + NAD+
6-hydroxynicotinate + NADH + H+
show the reaction diagram
nicotinate + H2O + NADP+
6-hydroxynicotinate + NADPH
show the reaction diagram
-
first step in the anaerobic decomposition of nicotinate, NADP+ may be the natural, primary electron acceptor
-
?
nicotinate + H2O + NADP+
6-hydroxynicotinate + NADPH + H+
show the reaction diagram