1.17.1.5: nicotinate dehydrogenase
This is an abbreviated version!
For detailed information about nicotinate dehydrogenase, go to the full flat file.
Word Map on EC 1.17.1.5
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1.17.1.5
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testosteroni
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comamonas
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putida
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6-hydroxynicotinate
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eubacterium
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barkeri
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multi-subunit
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t7-like
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pastoris
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surpass
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molybdenum
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chassis
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3-cyanopyridine
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pichia
- 1.17.1.5
- testosteroni
-
comamonas
- putida
- 6-hydroxynicotinate
- eubacterium
- barkeri
-
multi-subunit
-
t7-like
- pastoris
-
surpass
- molybdenum
-
chassis
- 3-cyanopyridine
-
pichia
Reaction
Synonyms
dehydrogenase, nicotinate, EC 1.5.1.13, NA hydroxylase, NAH, NahAB1B2, NDH, NdhL, NdhM, NdhS, nicotinate dehydrogenase, nicotinic acid hydroxylase, three-component NA hydroxylase, three-component nicotinic acid hydroxylase
ECTree
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Cofactor
Cofactor on EC 1.17.1.5 - nicotinate dehydrogenase
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flavin
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primary electron acceptor, 1.5-2 mol tightly bound flavin per mol of enzyme
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enzyme contains Fe/S centers, 8.3 mol iron per mol of enzyme, 1.5 mol acid-labile sulfur per mol of enzyme
4Fe-4S-center
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two [2Fe-2S] clusters, 5-7 atoms Fe per 160 kDa enzyme molecule
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enzyme contains bactopterin, an eubacterial modification of molybdopterin, the organic moiety of the molybdenum cofactor
Bactopterin
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molybdoenzyme with bactopterin, which differs from molybdopterin in MW, phosphate content and structure
molybdenum cofactor
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molybdoenzyme with eubacterial molybdenum cofactor contains bactopterin
molybdenum cofactor
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enzyme contains 1.5 mol molybdenum per mol of enzyme and bactopterin
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Mo is bound to a dinucleotide form of molybdopterin and is coordinated with selenium, 1 mol Mo per 160 kDa enzyme molecule, molybdenum is directly coordinated to selenium, Se-Mo center is required for enzymic oxidation of nicotinate
molybdopterin
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molybdenum in the molybdopterin cofactor is coordinated directly with a dissociable selenium moiety, molybdenum center plays a role in the reaction step involving hydroxylation of the heterocyclic ring with oxygen derived from water
NADP+
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specific for NADP+, artificial electron acceptors, i.e. benzyl viologen and 2,3,5-triphenyltetrazolium dyes, can replace NADP+
NADP+
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NADP+ as ultimate electron acceptor, can be replaced by various dyes
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NAD+ can not replace NADP+, but NADH can replace NADPH
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additional information
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enzyme contains a dissociable selenium moiety, which is coordinated directly with molybdenum in the molybdopterin cofactor, selenium is essential for enzyme activity, molar ratio of selenium to enzyme is 0.4-0.8, enzyme contains 1 g selenium per mol of native active enzyme, selenium is completely dissociated from protein in the SDS-gel
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additional information
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enzyme contains labile selenium cofactor which is essential for hydroxylase activity of enzyme, Se is directly coordinated to Mo, up to 1 Se atom per enzyme molecule
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additional information
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approximately 8 molecules tightly bound iron per enzyme molecule
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additional information
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enzyme contains 11 mol non-heme iron and 6 mol acid-labile sulfide per mole of enzyme
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additional information
Pusillimonas sp. (ex Stolz et al. 2005)
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no activity with FMN and NADP+
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