1.16.3.1: ferroxidase

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For detailed information about ferroxidase, go to the full flat file.

Word Map on EC 1.16.3.1

1.16.3.1

transferrin

hemoglobin

anemia

women

overload

children

c-reactive

albumin

erythrocyte

marrow

hematological

pregnancy

hepcidin

erythropoietin

hematocrit

dialysis

hereditary

infant

spleen

hemodialysis

ferric

thalassemia

covid-19

iron-deficient

ferrous

fever

haptoglobin

corpuscular

reticulocyte

admitted

iron-binding

micronutrient

folate

admission

wilson

creatinine

fibrinogen

transfusions

demographic

beta-thalassemia

bilirubin

sickle

transfused

acute-phase

coronavirus

protoporphyrin

anthropometric

d-dimer

deferoxamine

biotechnology

analysis

hemoglobinopathy

nutrition

medicine

Reaction

4 Fe(II) + 4 H+ +

= 4 Fe(III) + 2 H2O

Synonyms

AfFtn, apoferritin, bacterial ferritin, bacterial ferroxidase, bacterioferritin, bacterioferritin B, BFR, BfrB, blue copper oxidase, caeruloplasmin, ceruloplasmin, Cp115, Cp135, Cp200, CT1740, CtFtn, cyto-FOX, cytosolic FOX, DdBfr, Dpr, Dps, Dps protein, Dps-like peroxide resistance protein, Dps-Te, DpsA, DpsA-Te, DspA, EncA, encapsulin, encapsulin A, ferritin, ferro-O2-oxidoreductase, ferro:O2 oxidoreductase, ferroxidase, ferroxidase center of bacterioferritin, ferroxidase I, ferroxidase II, ferroxidase, iron II:oxygen oxidoreductase, Fet3, FET3 gene product, fet3p, FOX1, Ftn, FtnA, H ferritin, H' ferritin, H-chain ferritin, Helicobacter pylori neutrophil-activating protein, hephaestin, HP-NAP, HuHF, human ceruloplasmin form I, human H ferritin, human H-chain ferritin, iron(II): oxygen oxidoreductase, L-ferritin, M ferritin, MaDps, MCO1, MmcO, mnxDEFG, monophenol-o-monoxygenase, More, mouse ceruloplasmin, multicopper ferroxidase, multicopper oxidase, multicopper oxidase 1, multicopper oxidase CueO, multicopper oxidase-1, mushroom tyrosinase, mycobacterial multicopper oxidase, neutrophil-activating protein, non-ceruloplasmin ferroxidase, non-specific DNA-binding protein Dps/ferroxidase, rhHp, rHuHF, Rv0846c, serum ferroxidase, VcDps, VCE_000308, xanthine oxidoreductase

ECTree

1 Oxidoreductases

1.16 Oxidizing metal ions

1.16.3 With oxygen as acceptor

1.16.3.1 ferroxidase

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Results	in table
10	Activating Compound
21952	AA Sequence
32	Application
1	CAS Registry Number
23	Cloned(Commentary)
31	Crystallization (Commentary)
47479	Disease/ Diagnostics
7	Expression
73	General Information
2	General Stability
59	Inhibitors
164	KM Value [mM]
12	Localization
80	Metals/Ions
103	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
497	Organism
3	Pathway
2130	PDB ID
22	pH Optimum
2	pH Range
2	pH Stability
7	Posttranslational Modification
83	Protein Variants
48	Purification (Commentary)
4	Reaction
3	Reaction Type
166	Reference
126	Source Tissue
17	Specific Activity [micromol/min/mg]
12	Storage Stability
274	Substrates and Products (Substrate)
64	Subunits
159	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
41	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 1.16.3.1 - ferroxidase

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of cortex

in fluid from patients with Parkinson's disease, Alzheimer's disease, Huntington's disease, a significantly decreased ferroxidase activity is found agreeing with findings of iron deposition in these entities, while free copper is found to be increased in cerebrospinal fluid and appears to be a good biomarker of Parkinson's disease. The sum of nitrites and nitrates as end products of nitric oxide are increased in the degenerative diseases Parkinson's disease, Alzheimer's disease, Huntington's disease and lateral amyotrophic sclerosis and fluorescent lipoperoxidation products in three of them, excepting lateral amyotrophic sclerosis

epithelial cells

commercial preparation

vascular epithelial cell

nonadherent cells, T and B lymphocytes

Drosophila melanogaster

728678

midgut

Drosophila melanogaster

basal surface of midgut

mouse embryonal carcinoma cell line, addition of enzyme to culture medium induces aggregation within 24 h, with half-maximal effect at 0.05 mM. No association with apoptosis, necrosis or changes in secretory function. aggregation is less pronounce in aging neurons, K+ channels seem not to be involved

nephrotic urine

additional information

2 entries