1.16.3.1: ferroxidase

This is an abbreviated version!
For detailed information about ferroxidase, go to the full flat file.

Reaction

4 Fe(II) + 4 H+ +

Synonyms

AfFtn, apoferritin, bacterial ferritin, bacterial ferroxidase, bacterioferritin, bacterioferritin B, BFR, BfrB, blue copper oxidase, caeruloplasmin, ceruloplasmin, Cp115, Cp135, Cp200, CT1740, CtFtn, cyto-FOX, cytosolic FOX, DdBfr, Dpr, Dps, Dps protein, Dps-like peroxide resistance protein, Dps-Te, DpsA, DpsA-Te, DspA, EncA, encapsulin, encapsulin A, ferritin, ferro-O2-oxidoreductase, ferro:O2 oxidoreductase, ferroxidase, ferroxidase center of bacterioferritin, ferroxidase I, ferroxidase II, ferroxidase, iron II:oxygen oxidoreductase, Fet3, FET3 gene product, fet3p, FOX1, Ftn, FtnA, H ferritin, H' ferritin, H-chain ferritin, Helicobacter pylori neutrophil-activating protein, hephaestin, HP-NAP, HuHF, human ceruloplasmin form I, human H ferritin, human H-chain ferritin, iron(II): oxygen oxidoreductase, L-ferritin, M ferritin, MaDps, MCO1, MmcO, mnxDEFG, monophenol-o-monoxygenase, More, mouse ceruloplasmin, multicopper ferroxidase, multicopper oxidase, multicopper oxidase 1, multicopper oxidase CueO, multicopper oxidase-1, mushroom tyrosinase, mycobacterial multicopper oxidase, neutrophil-activating protein, non-ceruloplasmin ferroxidase, non-specific DNA-binding protein Dps/ferroxidase, rhHp, rHuHF, Rv0846c, serum ferroxidase, VcDps, VCE_000308, xanthine oxidoreductase

ECTree

     1 Oxidoreductases

         1.16 Oxidizing metal ions

             1.16.3 With oxygen as acceptor

                1.16.3.1 ferroxidase

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Results	in table
10	Activating Compound
21952	AA Sequence
32	Application
1	CAS Registry Number
23	Cloned(Commentary)
31	Crystallization (Commentary)
47479	Disease/ Diagnostics
7	Expression
73	General Information
2	General Stability
59	Inhibitors
164	KM Value [mM]
12	Localization
80	Metals/Ions
103	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
497	Organism
3	Pathway
2130	PDB ID
22	pH Optimum
2	pH Range
2	pH Stability
7	Posttranslational Modification
83	Protein Variants
48	Purification (Commentary)
4	Reaction
3	Reaction Type
166	Reference
126	Source Tissue
17	Specific Activity [micromol/min/mg]
12	Storage Stability
274	Substrates and Products (Substrate)
64	Subunits
159	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
41	Turnover Number [1/s]

Application

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Application on EC 1.16.3.1 - ferroxidase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Sus scrofa

-

enzyme can be used in analytical biochemistry, especially for the construction of enzyme sensors, enzymes immobilized in enzyme-containing membranes coating oxygen sensitive electrodes and serve for a specific amperometric determination of their substrates in biological materials

438025

biotechnology

11 entries

medicine

15 entries

nutrition

Oryctolagus cuniculus

-

treatment of rabbits with standard common rabbit diet and water ad libitum containing 40 mg fluoride per liter results in significant decrease of ceruloplasmin level in serum by days 35 and 70, with concomitant increase of serum adenosine eaminase and C-reactive protein

686833

biotechnology

Bacillus sp. (in: Bacteria)

-

expression system is developped producing about 2 mg of purified Bacillus sp. strain PL-12 Mn(II) oxidase per liter of Escherichia coli culture in 5 days

728688

biotechnology

Microbacterium arborescens

-

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

746541

biotechnology

Myxococcus xanthus

Q1D6H4

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

746541

biotechnology

Thermotoga maritima

Q9WZP2

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

746541

biotechnology

Halobacterium salinarum

B0R7W1

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

746541

biotechnology

Vibrio cholerae

A0A0H3Q5A5

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

746541

biotechnology

Streptomyces coelicolor

Q9R408

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

746541

biotechnology

Vibrio cholerae B33

-

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

-

biotechnology

Myxococcus xanthus DK 1622

-

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

-

biotechnology

Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145

-

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

-

biotechnology

Halobacterium salinarum ATCC 29341

-

compartmentalized iron oxide biomineralization by the enzyme yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications

-

medicine

Homo sapiens

P00450

mutations in human ceruloplasmin which result in a loss of activity, cause aceruloplasminemia, a neurodegenerative disease

438033

medicine

Homo sapiens

-

clinical interest relates to its critical role in the diagnosis of Wilson's disease in serum from patients, marked reduction in serum of patients

437996, 438006, 438007, 438014, 438027

medicine

Homo sapiens

-

homogenous ceruloplasmin with ferroxidase activity for the treatment of aplastic anemics, aplastic anemics have low levels of this enzyme, clinical trials have shown effective in 56% of cases

438016

medicine

Homo sapiens

-

different forms of normal and pathological ceruloplasmins, increasing ceruloplasmin activity in the blood of schizophrenics

437996

medicine

Homo sapiens

-

unusual antioxidant property of caeruloplasmin have important implications in vivo for conditions such as rheumatoid joint disease and Wilson's disease, where changes in copper homeostasis, caeruloplasmin and oxygen radicals are known to occur

438014

medicine

Homo sapiens

-

clinical importance because of its role in iron and copper metabolism and transport

438011

medicine

Homo sapiens

-

production of monoclonal antibodies for use in diagnostic kits for ceruloplasmin related diseases

659103

medicine

Mus musculus

-

both hypoxia and CuCl2 increase ceruloplasmin mRNA levels in hepatoma cells due to transcriptional induction of enzyme gene promoter

672774

medicine

Rattus norvegicus

-

after induction of cerebral ischemia by ligating bilateral common carotid arteries, the expression of ceruloplasmin mRNA in the cortex and hippocampus decreases, and the longer the animals experience ischemia, the lower the expression. Iron concentration correlates negatively with ceruloplasmin expression

689209

medicine

Homo sapiens

-

in fluid from patients with Parkinson's disease, Alzheimer's disease, and Huntington's disease, a significantly decreased ferroxidase activity is found agreeing with findings of iron deposition in these entities, while free copper is found to be increased in cerebrospinal fluid and appears to be a good biomarker of Parkinson's disease. The sum of nitrites and nitrates as end products of nitric oxide are increased in the degenerative diseases Parkinson's disease, Alzheimer's disease, Huntington's disease and lateral amyotrophic sclerosis, and fluorescent lipoperoxidation products in three of them, excepting lateral amyotrophic sclerosis

689179

medicine

Homo sapiens

-

serum ceruloplasmin concentrations of less than 0.20, of 0.14 and 0.10 g per l show positive predictive values of 48.3%, 100%, and 100%, respectively, for Wilson disease, and negative predictive values of 98.7%, 97.1%, and 91.9%, with measurement of ceruloplasmin concentration according to a nephelometric method, in ATP7B genotyped subjects. The diagnostic accuracy for Wilson disease using a serum ceruloplasmin concentration of 0.14 g per l as the local decision threshold is therefore better than using a threshold of 0.20 g per l

686151

medicine

Homo sapiens

-

Serum transferrin, albuminumin and Zinc concentrations are lower in patients with chronic lymphocytic leukemia while serum alpha-1-acid glycoprotein, ceruloplasmin, copper concentrations, and ceruloplasmin oxidase activity are higher in chronic lymphocytic leukemia patients when compared with the control group. Serum ceruloplasmin level positively correlates with serum ceruloplasmin oxidase activity in patients from the early stage group and in patients with advanced stage

690061

medicine

Homo sapiens

-

study on children with Henoch-Schönlein purpura. Patients at active stage have significantly higher myeloperoxidase activity, higher ceruloplasmin and total oxidant values than the control. Patiens have significantly lower arylesterase activity and lower free thiol levels. Significantly positive correlations are found between total oxidant status and myeloperoxidase, and total oxidant status and ceruloplasmin at disease onset, whereas a negative correlation is found between myeloperoxidase and thiol during remission

689331

medicine

Mus musculus

-

the requirement for a ferroxidase to maintain iron transport activity may explain brain iron overload in patients with aceruloplasminemia

686386

medicine

Oryctolagus cuniculus

-

treatment of rabbits with standard common rabbit diet and water ad libitum containing 40 mg fluoride per liter results in significant decrease of ceruloplasmin level in serum by days 35 and 70, with concomitant increase of serum adenosine eaminase and C-reactive protein

686833