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1.16.1.8: [methionine synthase] reductase

This is an abbreviated version!
For detailed information about [methionine synthase] reductase, go to the full flat file.

Word Map on EC 1.16.1.8

Reaction

2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine +

NADP+
= 2 [methionine synthase]-cob(II)alamin +
NADPH
+
H+
+ 2 S-adenosyl-L-methionine

Synonyms

EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase

ECTree

     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.8 [methionine synthase] reductase

Cloned

Cloned on EC 1.16.1.8 - [methionine synthase] reductase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
-
expression of full-length enzyme and flavin-binding domain as GST-tagged proteins
-
gene MTRR, genotyping
gene MTRR, genotyping for the A66G polymorphism and analysis of the association with cancer risk, overview. The G allele and GG variant genotypes are associated with a significantly increased cancer risk
-
gene MTRR, genotyping, and identification and mapping of single nucleotide polymorphisms
MTRR genotyping, quantitative real-time PCR enzyme expression analysis
-
recombinant expression of wild-type and mutant enzymes in Escherichia coli strain Rosetta2(DE3)pLysS