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1.15.1.1: superoxide dismutase

This is an abbreviated version!
For detailed information about superoxide dismutase, go to the full flat file.

Word Map on EC 1.15.1.1

Reaction

2 superoxide + 2 H+ =

O2
+
H2O2

Synonyms

AhSOD, alr2938, AmSOD, APE0743, ApMn-SOD1, ApMn-SOD2, ASAC_0498, Ca-Cu,Zn SOD, cambialistic superoxide dismutase, Cg-EcSOD, chloroplastic Fe-SOD, Cj-Cu, Zn SOD, cMn-SOD, cMnSOD, cold-active superoxide dismutase, copper, zinc superoxide dismutase, copper-zinc superoxide dismutase, copper/zinc superoxide dismutase, copper/zinc-superoxide dismutase, CpSOD, CSD1, CSD2, CtSOD, Cu, Zn SOD, Cu, Zn superoxide dismutase, Cu, Zn-superoxide dismutase, Cu, ZnSOD, Cu,Zn superoxide dismutase, Cu,Zn-SOD, Cu,Zn-superoxide dismutase, Cu,ZnSOD, Cu-Zn SOD, Cu-Zn superoxide dismutase, Cu-Zn-SOD, Cu/Zn SOD, Cu/Zn superoxide dismutase, Cu/Zn superoxide dismutase 1, Cu/Zn-SOD, Cu/Zn-SODI, Cu/Zn-SODII, Cu/Zn-superoxide dismutase, Cu/ZnSOD, cuprein, CuZn superoxide dismutase, CuZn superoxide dismutase 1, CuZn-SOD, CuZn-superoxide dismutase, CuZnSOD, cytMnSOD, cytocuprein, cytoplasmic manganese SOD, cytosolic Cu/Zn superoxide dismutase, cytosolic Cu/Zn-SOD, cytosolic manganese superoxide dismutase, DaSOD, dhsod-1, dismutase, superoxide, EC-SOD, ecCuZnSOD, ECSOD, ElFe-SOD, ElSOD, erythrocuprein, erythrocyte superoxide dismutase, eSOD, extracellular copper-zinc superoxide dismutase, extracellular CuZnSOD, extracellular SOD, extracellular superoxide dismutase, Fe-SOD, Fe-SODe, Fe-SOD_ASAC, Fe-superoxide dismutase, Fe-type SOD, Fe/Mn-SOD, Fe/Mn-type SOD, Fe/MnSOD, ferrisuperoxide dismutase, FeSOD, GTNG_2884, hEC-SOD, hemocuprein, hepatocuprein, high isoelectric point superoxide dismutase, intracellular Cu-Zn superoxide dismutase, iron SOD, iron SOD type, iron superoxide dismutase, iron-containing superoxide dismutase, iron-dependent superoxide dismutase, iron-superoxide dismutase, KmSod1p, LSOD, manganese superoxide dismutase, manganese-containing SOD, manganese-containing superoxide dismutase, MgMnSOD1, MgMnSOD2, mitMn-SOD, mitochondrial manganese superoxide dismutase, mMnSOD, Mn-containing superoxide dismutase, Mn-SOD, Mn-type SOD, Mn/Fe superoxide dismutase, MnSOD, MnSOD-2, MnSOD-3, MnSOD1, MnSOD47, More, mtMnSOD, mtSOD, nectarin I, neelaredoxin, Nlr, Of-cCu/ZnSOD, PASOD, perMn-SOD, pfSOD, PschSOD, PsSOD, PthipI-SODC, PthipI-SODC1, PthipI-SODC2, RmFeSOD, RsrSOD, SaCSD1, SaFe-SOD, sdB, SOD, SOD 1, SOD I, SOD-1, SOD-2, SOD-3, SOD-4, SOD1, SOD2, SOD3, SODA, SodB, SODB1, SODB2, SodC, SODF, SODI, SODII, SODIII, SODIV, SODS, SSO0316, superoxide dismutase, superoxide dismutase 1, superoxide dismutase I, superoxide dismutase II, superoxide dismutase [Cu-Zn]

ECTree

     1 Oxidoreductases
         1.15 Acting on superoxide as acceptor
             1.15.1 Acting on superoxide as acceptor (only sub-subclass identified to date)
                1.15.1.1 superoxide dismutase

Cloned

Cloned on EC 1.15.1.1 - superoxide dismutase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
AhSOD DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21 (DE3)
atypical SOD, functional and structural intermediate between Fe-SOD and Mn-SOD, expression in Escherichia coli
-
cDNA library construction, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genetic structure, the primary transcript is represented by five exons and encodes a peptide of 154 amino acids, quantitative PCR expression analysis. Screening of Of-cCu/ZnSOD 5'-flanking region reveal the presence of several important transcription factor binding sites that potentially govern the Cu/ZnSOD expression. Recombinant overexpression of MBP-tagged enzyme in Escherichia coli strain BL21(DE3)
construction of replication-deficient E1-partially E3-deleted clinical good manufacturing practice-grade adenoviruses encoding rabbit EC-SOD, free from contaminants, infusion of rabbit aorta segments, overview
-
Cu,Zn-SOD, expression in Escherichia coli as His-tagged protein, DNA and amino acid sequence analysis
Cu,Zn-SOD, expression of wild-type and mutant in Escherichia coli
-
Cu,Zn-SOD, overexpression in Escherichia coli
Cu,Zn-SOD, overexpression of wild-type and mutants in Spodoptera frugiperda cells Sf21 via baculovirus infection
-
Cu/Zn-SOD, DNA and amino acid sequence determination and analysis, semi-quantitative and/or real-time RT-PCR enzyme expression analysis
-
cytoplasmic manganese SOD, DNA and amino acid sequence determination and analysis
-
cytosolic MnSOD isozyme, DNA and amino acid sequence determination and analysis, phylogenetic analysis, sequence comparison, quantitative real-time RT-PCR expression analysis
DNA and amino acid sequence determination and analysis
-
DNA and amino acid sequence determination and analysis, ala16val polymorphism genotyping, overview, stably expression of human MnSOD-A16 and MnSOD-V16 variants in mouse fibroblasts
DNA and amino acid sequence determination and analysis, and sewquence comaprison, genetic structure, overview
-
DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)pLys
DNA and amino acid sequence determination and analysis, phylogenetic analysis, quantitative real-time PCR enzyme expresion analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta-gami
-
DNA and amino acid sequence determination and analysis, phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli
DNA and amino acid sequence determination and analysis, phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain M15
DNA and amino acid sequence determination and analysis, phylogenetic analysis, semiquantitative PCR enzyme expression analysis
DNA and amino acid sequence determination and analysis, phylogenetic tree, expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and analysis, real-time PCR enzyme expression analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and analysis, real-time RT-PCR expression analysis, sequence comparisons, expression in Escherichia coli strain QC779
DNA and amino acid sequence determination and analysis, sequence comparison
DNA and amino acid sequence determination and analysis, sequence comparison, expression of soluble enzyme in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and analysis, sequence comparison, His-tagged enzyme expression in Escherichia coli strains DH5alpha and M15
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21-SI
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and anaylsis, expression of wild-type and mutant in Escherichia coli
DNA and amino acid sequence determnination and analysis, expression of the His-tagged enzyme in Escherichia coli strain BL21(DE3)
-
EC-SOD, overexpression in Escherichia coli as His-tagged protein and in Tn-5B1-4 cells of Trichoplusia ni via baculovirus infection
-
expressed in Escherichia coli. Although the recombinant protein is soluble, little activity is observed due to the lack of metal incorporation. Reconstitution of the enzyme by heat treatment with either Mn2+ or Fe2+ yields a highly active protein
expressed in THP-1- cells
-
expression analysis in homozygous LDL-receptor-knockout mice, heterozygous ob/+, and wild-type C57BL6 mice
-
expression analysis in TCAP-1 treated or untreated cells at different pH
-
expression in Escherichi coli
expression in Escherichia coli
expression in Escherichia coli strain BL21 (DE3)
-
expression in Escherichia coli strain BL21(DE3)
-
expression in Pichia pastoris, DNA and amino acid sequence determination and comparison
expression in yeast
-
expression of H63C mutant in Escherichia coli
-
expression of His-tagged SOD in Escherichia coli strain BL21(DE3)
-
expression of His6-and thioredoxin-tagged enzyme in Escherichia coli
expression of human SOD in Escherichia coli
-
expression of recombinant chimera MnSOD-VHb in Escherichia coli strain BL21(DE3)
-
expression of SOD1 in Leishmania tarentolae strain P10
expression of the CuZn-SOD in Escherichia coli
-
expression of wild-type and mutant enzymes in Escherichia coli
expression of wild-type and mutant enzymes in Escherichia coli strain JM109(DE3)
-
Fe-SOD, expression in Escherichia coli, DNA and amino acid sequence determination
from genomic DNA, expression in Escherichia coli strain QC774
-
from muscle, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis
gene BbSod1, DNA and amino acid sequence determination and analysis, phylogenetic analysis, subcloning in Escherichia coli strain DH5alpha, expression as His-tagged wild-type and mutant enzymes and as His-tagged Saccharomyces cerevisiae superoxide dismutase 1 copper chaperone-fusion enzyme, i.e. SOD1-Lys7, in Escherichia coli BL21(DE3)
gene CSD1, DNA and amino acid sequence determination and analysis, expression as GST-tagged protein in Escherichia coli strain BL21(DE3)
gene CSD1, DNA and amino acid sequence determination and analysis, sequence comparisons, real-time quantitative PCR enzyme expression analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta-gami
gene Ctsod, DNA and amino acid sequence determination and analysis, phylogenetic tree, subcloning in Escherichia coli strains DH5a and JM109, expression in Pichia pastoris strain GS115, the recombinant yeast exhibit higher stress resistance than the control yeast cells to salt and superoxide-generating agents, such as paraquat and menadione
Thermochaetoides thermophila
gene CuZnSOD, DNA and amino acid sequence determination and analysis, recombinant His6-tagged Cp-icCuZnSOD with high enzyme activity is induced to be expressed in Escherichia coli strain BL21(DE3) as a soluble form by IPTG supplemented with Cu/Zn ions at 20°C for 8 h
-
gene cz1, expression of Cu,ZnSOD in Pichia pastoris strain GS115
Thermochaetoides thermophila
gene dhsod-1, DNA and amino acid sequence determination and analysis, sequence comparisons
-
gene Fe-SOD, DNA and amino acid sequence deteremination and analysis, sequence comparisons, expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) cytosol, expression as thioredoxin-fusion protein in Escherichia coli
gene KmSod1, DNA and amino acid sequence determination and analysis, sequence comparisons, overexpression of Cu/Zn-SOD under the control of the KlADH4 promoter in strain L3 from a multicopy plasmid, subcloning in Escherichia coli strain DH5alpha
gene locus Asac_0498, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta-gami(DE3)
gene MgMnSOD1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, tissue expression analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta(DE3). Expression of HBT95-MgMnSOD1-sGFP vector driven by a CaMV 35S promoter to determine the intracellular localization of MgMnSOD1
gene MgMnSOD2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, tissue expression analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta(DE3)
gene mnsod, expression in Pichia pastoris strain GS115. Transformed recombinant yeast cells exhibit higher stress resistance to salt and oxidative stress-inducing agents than control yeast cells
Thermochaetoides thermophila
gene MSD1, DNA and amino acid sequence determination and analysis, expression as GST-tagged protein in Escherichia coli strain BL21(DE3)
gene RmFeSOD, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3). Under copper stress experiment, the RmFeSOD-expressing Escherichia coli cells exhibit a better growth than nontransformed bacteria
gene RsrSOD, recombinant expression under the control of the CaMV35S promoter, in Brassica oleracea var. italica via Agrobacterium tumefaciens-mediated transformation. Both gene expression and enzyme activity of SOD increase significantly in transgenic lines when challenged with Hyaloperonospora parasitica, the causal agent of downy mildew. Three lines exhibit high resistance against downy mildew, with disease symptoms restricted completely
-
gene SeCuZnSOD, DNA and amino acid sequence determination and analysis, genomic organization, sequence alignment and phylogenetic analysis, quantitative RT-PCR expression analysis, recombinant expression as GST-tagged enzyme in Escherichia coli
gene SOD, and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
gene sod, cloning from genomic DNA, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain JM109(DE3)
gene sod, DNA and amino acid sequence determination and analysis
gene sod, DNA and amino acid sequence determination and analysis, expression analysis, sequence comparisons
gene sod, DNA and amino acid sequence determination and analysis, functional overexpression of the soluble enzyme in Escherichia coli
gene sod, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparison, phylogenetic tree, inducible expression in Pichia pastoris strain GS115 using the AOX1 promoter
gene sod, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
gene sod, expression of wild-type and mutant soluble enzymes in Escherichia coli strain QC774, that lacks the genes encoding endogeneous FeSOD, SodB-, and MnSOD, SodA-
gene sod-1, expression analysis
-
gene Sod1, a single copy, expression analysis, recombinant expression in transgenic Oryza sativa plants, plants are more tolerant to methyl viologen mediated oxidative stress in comparison to the untransformed control plants and also withstand salinity stress
-
gene SOD2, recombinant expression in Escherichia coli
gene SOD3, cloning of EC-SOD and recombinant expression of wild-type and truncated mutant FLAG-tagged hEC-SOD enzymes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method, both full length and truncated hEC-SOD proteins are enzymatically active
gene sod3, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, semiquantitative and quantitative RT-PCR expression analysis
gene sod3, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, semiquantitative and quantitative RT-PCR expression analysis, recombinant expression as thioredoxin-fusion enzyme
gene sodA, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree
gene sodA, DNA and amino acid sequence determination and analysis, sequence comparison
-
gene sodA, DNA and amino acid sequence determination and analysis, sequence comparison, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
gene sodA, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, semi-quantitative expression analysis
gene sodA, DNA and amino acid sequence determination and analysis, subcloning in Escherichia coli strains DH5alpha and BW19851, complementation of an enzyme-deficient mutant strain
-
gene sodA, expression of SodA in and complementation of enzyme-deficient Escherichia coli strain PN134. Expressing YeSodA confers resistance to paraquat to the Escherichia coli strain
gene sodA-1, DNA and amino acid sequence determination and analysis, chromosomal organization, expression in Escherichia coli strain QC779
gene sodA-2, DNA and amino acid sequence determination and analysis, chromosomal organization, expression in Escherichia coli strain QC779
gene sodB, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)
gene sodB, DNA and amino acid sequence determination and analysis, sequence comparison, expression in Escherichia coli strain BL21(DE3)
gene sodB, expression of SodB in and complementation of enzyme-deficient Escherichia coli strain PN134. Expressing YeSodB confers resistance to paraquat to the Escherichia coli strain
gene sodB, overexpression of the His6-tagged type A isozyme in Escherichia coli strain BL21(DE3)
-
gene sodC, DNA and amino acid sequence determination and analysis
-
gene sodC, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged enzyme in Escherichia coli, recombinant overexpression of the enzyme from AS454(pREB102) in an Escherichia coli sodC mutant leads to complementation restoring resistance to H2O2 killing to wild-type levels
gene sodC, SodC cannot be expressed in Escherichia coli strain BL21(DE3)
gene sodC, subcloning in Escherichia coli, complementation of the sodC mutant, expression of a SodC-FLAG fusion protein in strain K56-2
-
His-tagged MnSOD-2 and MnSOD-3
-
isozyme SODI, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis
isozyme SODII, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis
mitochondrial MnSOD isozyme, DNA and amino acid sequence determination and analysis, phylogenetic analysis, sequence comparison, quantitative real-time RT-PCR expression analysis
Mn-SOD, DNA and amino acid sequence determination and analysis, semi-quantitative and/or real-time RT-PCR enzyme expression analysis
-
Mn-SOD, expression in Escherichia coli
-
Mn-SOD, expression in Escherichia coli as His-tagged protein, DNA sequence analysis
Mn-SOD, expression of wild-type and mutants in Escherichia coli
-
MnSOD, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic tree, and quantitative real-time RT-PCR expression analysis, expression in Escherichia coli strain BL21(DE3)
molecular heterogeneity of the enzyme in Crypthecodinium cohnii at both genomic and transcriptional levels, DNA and amino acid sequence determination and analysis of genes sod1-sod17, phylogenetic analysis, the Crypthecodinium cohnii SODs form a monophyletic group and are all acquired by the same event of horizontal gene transfer, functional overexpression of sod1 in Escherichia coli
overexpressed as a GST fusion protein at a high level in Escherichia coli
overexpression in Saccharomyces cerevisiae mutant lacking Cu,Zn-SOD, restores activity of the mutant
overexpression of wild-type and mutant enzymes in hind limb muscle of transgenic mice
-
phylogenetic tree
-
recombinant expression in in a copper-tolerant yeast, Cryptococcus sp. strain N6, two distinct bands exhibiting SOD activity appear on native PAGE: one band, with higher mobility, appears when the cells are grown without CuSO4, and the other band appears when the cells are grown with 10 mM CuSO4. Cells grown with 3 mM CuSO4 produce both SOD isoforms
-
recombinant expression in Mus musculus, CX3CR1-GFP mice, heterogenic parabiosis between mutant and wild-type mice confers a significant protection to wild-type mice, whereas mice with R213G knock-in mutation, a human single nucleotide polymorphism leading to reduced binding EcSOD in peripheral organs, exacerbate the organ damages. Recombinant EcSOD overexpressed in skeletal muscle-specific mutant mice redistributes to other peripheral organs through the circulation and enriches at the endothelium of the vasculatures. Mutant mice are resistant to endotoxemia (induced by lipopolysaccharide injection) in developing MODS with significantly reduces mortality and organ damages compared with the wild-type littermates
-
recombinant expression of His-tagged soluble chloroplastic isoform CuZn-SOD in its enzymatically active and stable form in Escherichia coli, and optimization of culture conditions, best at 18°C and upon isopropyl beta-D-1-thiogalactopyranoside induction, recombinant enzyme production process optimization
recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli BL21(DE3)
recombinant expression of His-tagged wild-type enzyme SODAp and NTD-fused N-terminal domain ntdSODAp in Escherichia coli strain BL21(DE3)
-
SaFe-SOD, DNA and amino acid sequence determination and analysis, quantitative real-time PCR enzyme expression analysis, functional recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta-gami
-
semi-quantitative enzyme expression analysis
-
single copy gene, DNA and amino acid sequence determination and analysis
SOD, DNA and amino acid sequence determination and analysis, promoter analysis, phylogentic tree
strains KT2440 and PAO1, genome expression profiling, overview
-
subcloning in Escherichia coli, expression of iron-SOD or manganese-SOD in and complementation of an enzyme-deficient double mutant strain
-
two splicing variants of PthipI-SODC1, presence of two transcripts of PthipI-SODC1, hipI-SODC1b and hipI-SODC1s. hipI-SODC1b is 69 bp longer than hipI-SODC1s due to an alternative splicing event involving an alternative donor splice site in the sixth intron. Transcript analysis
-