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1.14.99.48: heme oxygenase (staphylobilin-producing)

This is an abbreviated version!
For detailed information about heme oxygenase (staphylobilin-producing), go to the full flat file.

Word Map on EC 1.14.99.48

Reaction

protoheme
+ 5 reduced acceptor + 4 O2 =
beta-staphylobilin
+
Fe2+
+
formaldehyde
+ 5 acceptor + 4 H2O

Synonyms

haem oxidase, haem oxygenase, heme oxidase, heme oxygenase, heme oxygenase (decyclizing), heme oxygenase (staphylobilin-producing) 1, heme oxygenase (staphylobilin-producing) 2, isdG, isdI

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.48 heme oxygenase (staphylobilin-producing)

Reference

Reference on EC 1.14.99.48 - heme oxygenase (staphylobilin-producing)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Haley, K.P.; Janson, E.M.; Heilbronner, S.; Foster, T.J.; Skaar, E.P.
Staphylococcus lugdunensis IsdG liberates iron from host heme
J. Bacteriol.
193
4749-4757
2011
Staphylococcus lugdunensis (A0A133QBY0), Staphylococcus lugdunensis N920143 (A0A133QBY0)
Manually annotated by BRENDA team
Skaar, E.P.; Gaspar, A.H.; Schneewind, O.
IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus
J. Biol. Chem.
279
436-443
2004
Staphylococcus aureus (Q7A649), Staphylococcus aureus (Q7A827), Staphylococcus aureus N315 (Q7A649), Staphylococcus aureus N315 (Q7A827)
Manually annotated by BRENDA team
Wu, R.; Skaar, E.P.; Zhang, R.; Joachimiak, G.; Gornicki, P.; Schneewind, O.; Joachimiak, A.
Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases
J. Biol. Chem.
280
2840-2846
2005
Staphylococcus aureus (Q8NX62), Staphylococcus aureus (Q99X56), Staphylococcus aureus ATCC 700699 (Q99X56), Staphylococcus aureus MW2 (Q8NX62)
Manually annotated by BRENDA team
Lee, W.C.; Reniere, M.L.; Skaar, E.P.; Murphy, M.E.
Ruffling of metalloporphyrins bound to IsdG and IsdI, two heme-degrading enzymes in Staphylococcus aureus
J. Biol. Chem.
283
30957-30963
2008
Staphylococcus aureus (Q7A649), Staphylococcus aureus (Q7A827)
Manually annotated by BRENDA team
Loutet, S.A.; Kobylarz, M.J.; Chau, C.H.; Murphy, M.E.
IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus
J. Biol. Chem.
288
25749-25759
2013
Staphylococcus aureus (Q7A649), Staphylococcus aureus (Q7A827), Staphylococcus aureus N315 (Q7A649), Staphylococcus aureus N315 (Q7A827)
Manually annotated by BRENDA team
Reniere, M.L.; Skaar, E.P.
Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem
Mol. Microbiol.
69
1304-1315
2008
Staphylococcus aureus (Q7A649), Staphylococcus aureus (Q7A827), Staphylococcus aureus N315 (Q7A649), Staphylococcus aureus N315 (Q7A827)
Manually annotated by BRENDA team
Reniere, M.L.; Ukpabi, G.N.; Harry, S.R.; Stec, D.F.; Krull, R.; Wright, D.W.; Bachmann, B.O.; Murphy, M.E.; Skaar, E.P.
The IsdG-family of haem oxygenases degrades haem to a novel chromophore
Mol. Microbiol.
75
1529-1538
2010
Staphylococcus aureus (Q7A649), Staphylococcus aureus (Q7A827), Staphylococcus aureus N315 (Q7A649), Staphylococcus aureus N315 (Q7A827)
Manually annotated by BRENDA team
Reniere, M.L.; Haley, K.P.; Skaar, E.P.
The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme
Biochemistry
50
6730-6737
2011
Staphylococcus aureus (A6QG37), Staphylococcus aureus Newman (A6QG37)
Manually annotated by BRENDA team
Matsui, T.; Nambu, S.; Ono, Y.; Goulding, C.W.; Tsumoto, K.; Ikeda-Saito, M.
Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide
Biochemistry
52
3025-3027
2013
Staphylococcus aureus
Manually annotated by BRENDA team
Ukpabi, G.; Takayama, S.J.; Mauk, A.G.; Murphy, M.E.
Inactivation of the heme degrading enzyme IsdI by an active site substitution that diminishes heme ruffling
J. Biol. Chem.
287
34179-34188
2012
Staphylococcus aureus (Q7A827), Staphylococcus aureus N315 (Q7A827)
Manually annotated by BRENDA team
Streit, B.R.; Kant, R.; Tokmina-Lukaszewska, M.; Celis, A.I.; Machovina, M.M.; Skaar, E.P.; Bothner, B.; DuBois, J.L.
Time-resolved studies of IsdG protein identify molecular signposts along the non-canonical heme oxygenase pathway
J. Biol. Chem.
291
862-871
2016
Staphylococcus aureus (Q7A649), Staphylococcus aureus N315 (Q7A649)
Manually annotated by BRENDA team
Lockhart, C.L.; Conger, M.A.; Pittman, D.S.; Liptak, M.D.
Hydrogen bond donation to the heme distal ligand of Staphylococcus aureus IsdG tunes the electronic structure
J. Biol. Inorg. Chem.
20
757-770
2015
Staphylococcus aureus (Q8NX62), Staphylococcus aureus MW2 (Q8NX62)
Manually annotated by BRENDA team
Conger, M.A.; Pokhrel, D.; Liptak, M.D.
Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor
Metallomics
9
556-563
2017
Staphylococcus aureus
Manually annotated by BRENDA team