1.14.99.46: pyrimidine oxygenase
This is an abbreviated version!
For detailed information about pyrimidine oxygenase, go to the full flat file.
Reaction
Synonyms
RutA
ECTree
1.14.99.46 pyrimidine oxygenaseAdvanced search results
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General Information on EC 1.14.99.46 - pyrimidine oxygenase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
metabolism
physiological function
RutA has a central role in the Rut pathway, which is composed of seven proteins, all of which are required by Escherichia coli K-12 to grow on uracil as the sole nitrogen source
additional information
the Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37°C, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature, RutE/YdfG function. The catabolic pathway is highly expressed even in the absence of exogenous substrate and at 37°C
metabolism
RutA has a central role in the Rut pathway, a pyrimidine catabolic pathway, which is composed of seven proteins, all of which are required by Escherichia coli K-12 to grow on uracil as the sole nitrogen source, pathway overview. RutA works in conjunction with the flavin reductase RutF
metabolism
RutA is involved in the pyrimidine catabolic Rut pathway, which converts uracil to 3-hydroxypropionate or 2-methyl-3-hydroxypropionate. The flavoenzyme RutA, along with the flavin reductase RutF, catalyzes the initial uracil ring opening by an unprecedented oxidative hydrolysis reaction to give 3-ureidoacrylate
metabolism
RutA is the first enzyme of the pyrimidine catabolizing Rut pathway, the involved enzymes are encoded by the rut operon, including rutRABCDEFG and ydfG, overview. RutF functions as a flavin reductase that is required to regenerate the flavin mononucleotide, FMN, cofactor
