1.14.99.38: cholesterol 25-monooxygenase
This is an abbreviated version!
For detailed information about cholesterol 25-monooxygenase, go to the full flat file.
Word Map on EC 1.14.99.38
-
1.14.99.38
-
pregnane
-
cyp2b10
-
25-hydroxycholesterol
-
androstane
-
oxysterols
-
drug-metabolizing
-
phenobarbital
-
cyp2c29
-
ugt1a1
-
interferon-stimulated
-
cyp3a13
-
apap-induced
-
lithocholic
-
acetaminophen-induced
-
pxr-mediated
-
cyp2a4
-
pxr-null
-
tcpobop
-
medicine
- 1.14.99.38
-
pregnane
-
cyp2b10
- 25-hydroxycholesterol
-
androstane
- oxysterols
-
drug-metabolizing
- phenobarbital
-
cyp2c29
- ugt1a1
-
interferon-stimulated
-
cyp3a13
-
apap-induced
-
lithocholic
-
acetaminophen-induced
-
pxr-mediated
-
cyp2a4
-
pxr-null
-
tcpobop
- medicine
Reaction
Synonyms
CH25A, CH25H, cholesterol 25-hydroxylase, cholesterol 25-monooxygenase, cholesterol-25-hydroxylase, CYP1A2, CYP27A1, CYP2C9, CYP2D6, CYP3A, Cyp3a11, CYP3A4
ECTree
1.14.99.38 cholesterol 25-monooxygenaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.14.99.38 - cholesterol 25-monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
genetic variability in the set of cholesterol metabolism genes: cholesterol 25-hydroxylase, cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 does not influence the development of Alzheimers disease
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP1A2 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2C9 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2D6 compared to marker enzyme CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
production of 25-hydroxycholesterol by intact CYP3A4, most significant activity is 25-hydroxylation, which is higher than that of 4beta-hydroxylation, a marker activity of CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
-
-
?
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
-
testicular macrophagers play an important role in the differentiation of Leydig cells through the secretion of 25-hydroxycholesterol
-
-
?
additional information
?
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
additional information
?
-
-
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
-
-
?
