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1.14.99.36: beta-carotene 15,15'-monooxygenase

This is an abbreviated version!
For detailed information about beta-carotene 15,15'-monooxygenase, go to the full flat file.

Word Map on EC 1.14.99.36

deleted. Now classified as EC 1.13.11.63, beta-carotene 15,15'-dioxygenase


ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.36 beta-carotene 15,15'-monooxygenase

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Resultsin table
13Expression
62General Information
4kcat/KM [mM/s]

Expression

Expression on EC 1.14.99.36 - beta-carotene 15,15'-monooxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
all-trans-retinal at 0.001 mM suppresses bcmo1 expression
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all-trans-retinal does not affect liver bcmo1 expression
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all-trans-retinal suppresses liver, lung and testis bcmo1 expression, and 9-cis-retinal in lung and testis, in vitamin A-deficient rats
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BCM gene expression in the kidney of puromycin aminonucleoside-treated rats is increased
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BCM gene expression in the liver and intestines of puromycin aminonucleoside-treated rats is decreased
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Bcmo1 expression is induced during adipocyte differentiation
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beta-carotene and all-trans-retinal at 10-100 nM induces bcmo1 expression
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chronic alcohol intake significantly upregulates hepatic BCMO1 expression in rats, possibly mediated via PPAR-gamma
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exposure to beta-carotene suppresses CMO1 expression at both mRNA and protein levels. beta-Carotene, but not all-trans retinoic acid, decreases CMO1 promoter activity in a time- and dosage-dependent manner. This beta-carotene-mediated inhibition of CMO1 expression results from decreased binding of peroxisome proliferator-activated receptor gamma and retinoid X receptor alpha in the CMO1 promoter
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intestinal BCM gene expresssion is increased in obese and dyslipedemic rats
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Isx, intestine specific homeobox, participates in the maintenance of vitamin A by regulating Bcmo1 expression in the intestine
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severe vitamin A deficiency markedly decreases intestine-specific transcription factor intestine-specific homeobox expression accompanied by an increase in BCMO1 expression in duodenum and jejunum
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